Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Roberto, Battistutta"'
Autor:
Emanuele Fornasier, Simone Fabbian, Haidi Shehi, Janine Enderle, Barbara Gatto, Daniele Volpin, Barbara Biondi, Massimo Bellanda, Gabriele Giachin, Alice Sosic, Roberto Battistutta
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Many enzymes work as homodimers with two distant catalytic sites, but the reason for this choice is often not clear. For the main protease Mpro of SARS-CoV-2, dimerization is essential for function and plays a regulatory role during the coro
Externí odkaz:
https://doaj.org/article/1acb2ae723db4d6792e6ca45800ef122
Autor:
Marco Malatesta, Emanuele Fornasier, Martino Luigi Di Salvo, Angela Tramonti, Erika Zangelmi, Alessio Peracchi, Andrea Secchi, Eugenia Polverini, Gabriele Giachin, Roberto Battistutta, Roberto Contestabile, Riccardo Percudani
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The increasing availability of experimental and computational protein structures entices their use for function prediction. Here we develop an automated procedure to identify enzymes involved in metabolic reactions by assessing substrate con
Externí odkaz:
https://doaj.org/article/14c67f718fbf493085d50d336b285301
Autor:
Simone Fabbian, Gabriele Giachin, Massimo Bellanda, Christian Borgo, Maria Ruzzene, Giacomo Spuri, Ambra Campofelice, Laura Veneziano, Marcella Bonchio, Mauro Carraro, Roberto Battistutta
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
CK2 is a Ser/Thr protein kinase involved in many cellular processes such as gene expression, cell cycle progression, cell growth and differentiation, embryogenesis, and apoptosis. Aberrantly high CK2 activity is widely documented in cancer, but the e
Externí odkaz:
https://doaj.org/article/f0ac466cbae14ad29dbd0b914b9bdad7
Autor:
Ilaria Zamparo, Simona Francia, Sira Angela Franchi, Nelly Redolfi, Elisa Costanzi, Axelle Kerstens, Yosuke Fukutani, Roberto Battistutta, Patrizia Polverino de Laureto, Sebastian Munck, Bart De Strooper, Hiroaki Matsunami, Claudia Lodovichi
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4334-4348.e7 (2019)
Summary: In mammals, odorant receptors not only detect odors but also define the target in the olfactory bulb, where sensory neurons project to give rise to the sensory map. The odorant receptor is expressed at the cilia, where it binds odorants, and
Externí odkaz:
https://doaj.org/article/9888dc968b794fb7bb4f863389e94141
Autor:
Emanuele Fornasier, Maria Ludovica Macchia, Gabriele Giachin, Alice Sosic, Matteo Pavan, Mattia Sturlese, Cristiano Salata, Stefano Moro, Barbara Gatto, Massimo Bellanda, Roberto Battistutta
Publikováno v:
'Acta Crystallographica D ', vol: 78, pages: 363-378 (2022)
The SARS-CoV-2 main protease (Mpro) has a pivotal role in mediating viral genome replication and transcription of the coronavirus, making it a promising target for drugs against the COVID-19 pandemic. Here, a crystal structure is presented in which M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965673c7a8083601ad805f3cca624e6b
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:59489
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:59489
Autor:
Léa El Khoury, Zhifeng Jing, Alberto Cuzzolin, Alessandro Deplano, Daniele Loco, Boris Sattarov, Florent Hédin, Sebastian Wendeborn, Chris Ho, Dina El Ahdab, Theo Jaffrelot Inizan, Mattia Sturlese, Alice Sosic, Martina Volpiana, Angela Lugato, Marco Barone, Barbara Gatto, Maria Ludovica Macchia, Massimo Bellanda, Roberto Battistutta, Cristiano Salata, Ivan Kondratov, Rustam Iminov, Andrii Khairulin, Yaroslav Mykhalonok, Anton Pochepko, Volodymyr Chashka-Ratushnyi, Iaroslava Kos, Stefano Moro, Matthieu Montes, Pengyu Ren, Jay W. Ponder, Louis Lagardère, Jean-Philip Piquemal, Davide Sabbadin
Publikováno v:
Chemical Science
Chemical Science, 2022, ⟨10.1039/D1SC05892D⟩
Chemical Science, 2022, ⟨10.1039/D1SC05892D⟩
We report a fast-track computationally-driven discovery of new SARS-CoV2 Main Protease (Mpro) inhibitors whose potency range from mM for initial non-covalent ligands to high nM for the final covalent compound (IC50=830 +/- 50 nM). The project extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fb3c770ad5b156560e839423dea37d
https://hal.science/hal-03361062
https://hal.science/hal-03361062
Autor:
Léa, El Khoury, Zhifeng, Jing, Alberto, Cuzzolin, Alessandro, Deplano, Daniele, Loco, Boris, Sattarov, Florent, Hédin, Sebastian, Wendeborn, Chris, Ho, Dina, El Ahdab, Theo, Jaffrelot Inizan, Mattia, Sturlese, Alice, Sosic, Martina, Volpiana, Angela, Lugato, Marco, Barone, Barbara, Gatto, Maria Ludovica, Macchia, Massimo, Bellanda, Roberto, Battistutta, Cristiano, Salata, Ivan, Kondratov, Rustam, Iminov, Andrii, Khairulin, Yaroslav, Mykhalonok, Anton, Pochepko, Volodymyr, Chashka-Ratushnyi, Iaroslava, Kos, Stefano, Moro, Matthieu, Montes, Pengyu, Ren, Jay W, Ponder, Louis, Lagardère, Jean-Philip, Piquemal, Davide, Sabbadin
Publikováno v:
Chemical science. 13(13)
We report a fast-track computationally driven discovery of new SARS-CoV-2 main protease (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09aa3a22bcf963a31ded78c4b6b5bf9a
https://pubmed.ncbi.nlm.nih.gov/35432906
https://pubmed.ncbi.nlm.nih.gov/35432906
Autor:
Roberto Battistutta, Andrea Venerando, Maria Ruzzene, Stefano Dall'Acqua, Andrea Dalle Vedove, Francesca Zonta, Graziano Lolli, Giorgio Cozza
Publikováno v:
The FEBS Journal. 287:1850-1864
Protein kinase CK2 is an antiapoptotic cancer-sustaining protein. Curcumin, reported previously as a CK2 inhibitor, is too bulky to be accommodated in the CK2 active site and rapidly degrades in solution generating various ATP-mimetic inhibitors; wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2dc5fad06f0f5d4fd2571819ef52d4
https://doi.org/10.1111/febs.15111
https://doi.org/10.1111/febs.15111
Autor:
Antonio Macchiarulo, Roberto Battistutta, Alice Coletti, Barbara Zambelli, Massimo Bellanda, Elisa Costanzi
Publikováno v:
Journal of structural biology. 213(2)
SLC26A5 transporter prestin is fundamental for the higher hearing sensitivity and frequency selectivity of mammals. Prestin is a voltage-dependent transporter found in the cochlear outer hair cells responsible for their electromotility. Intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b7654d824ae2cd815c11a5e1cc4bb9
https://pubmed.ncbi.nlm.nih.gov/33667636
https://pubmed.ncbi.nlm.nih.gov/33667636
Autor:
Roberto Battistutta, Giovanni Ribaudo, Stefania Sarno, Andrea Dalle Vedove, Giuseppe Zagotto, Francesca Zonta, Graziano Lolli, Nicola Demitri, Alberto Ongaro, Maria Ruzzene, Giulia Cazzanelli, Enrico Zanforlin
Protein kinase CK2 sustains cancer growth, especially in hematological malignancies. Its inhibitor SRPIN803, based on a 6-methylene-5-imino-1,3,4-thiadiazolopyrimidin-7-one scaffold, showed notable specificity. Our synthesis of the initially proposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37891d16707635691d74728a3c95264b
http://hdl.handle.net/11572/275324
http://hdl.handle.net/11572/275324