Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Roberta Turiello"'
Autor:
Frank A. Giordano, Julian P. Layer, Sonia Leonardelli, Lea L. Friker, Roberta Turiello, Dillon Corvino, Thomas Zeyen, Christina Schaub, Wolf Müller, Elena Sperk, Leonard Christopher Schmeel, Katharina Sahm, Christoph Oster, Sied Kebir, Peter Hambsch, Torsten Pietsch, Sotirios Bisdas, Michael Platten, Martin Glas, Clemens Seidel, Ulrich Herrlinger, Michael Hölzel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The chemokine CXCL12 promotes glioblastoma (GBM) recurrence after radiotherapy (RT) by facilitating vasculogenesis. Here we report outcomes of the dose-escalation part of GLORIA (NCT04121455), a phase I/II trial combining RT and the CXCL12-n
Externí odkaz:
https://doaj.org/article/a461b70c215e421cabb2b9a14f5dfb4b
Autor:
Caterina Giraulo, Roberta Turiello, Lavinia Orlando, Sonia Leonardelli, Jennifer Landsberg, Raffaella Belvedere, Georg Rolshoven, Christa E. Müller, Michael Hölzel, Silvana Morello
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115225- (2023)
CD73 is the key enzyme in the generation of extracellular adenosine, a mediator involved in tumor progression, tumor immune escape and resistance to anti-cancer therapeutics. Microenvironmental conditions influence the expression of CD73 in tumor cel
Externí odkaz:
https://doaj.org/article/2d01d7fab2754c648cad5647ebf10af7
Autor:
Elena De Marchi, Anna Pegoraro, Roberta Turiello, Francesco Di Virgilio, Silvana Morello, Elena Adinolfi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
ATP and adenosine are key constituents of the tumor niche where they exert opposite and complementary roles. ATP can be released in response to cell damage or actively released by tumor cells and subsequently degraded into adenosine, which accumulate
Externí odkaz:
https://doaj.org/article/e176bc02db0345e7a0589c15adea8acb
Autor:
Mariaelena Capone, Gabriele Madonna, Ester Simeone, Paolo A Ascierto, Antonio Sorrentino, Roberta Turiello, Elva Morretta, Maria Chiara Monti, Rosa Azzaro, Silvana Morello, Pasquale Del Gaudio
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background CD73 is an ectonucleotidase producing the immunosuppressor mediator adenosine. Elevated levels of circulating CD73 in patients with cancer have been associated with disease progression and poor response to immunotherapy. Immunosuppressive
Externí odkaz:
https://doaj.org/article/16eb3e6d99c6479e82f78953f59e5073
Autor:
Mariaelena Capone, Federica Fratangelo, Diana Giannarelli, Claudia Sorrentino, Roberta Turiello, Serena Zanotta, Domenico Galati, Gabriele Madonna, Marilena Tuffanelli, Luigi Scarpato, Antonio M. Grimaldi, Assunta Esposito, Rosa Azzaro, Antonio Pinto, Ernesta Cavalcanti, Aldo Pinto, Silvana Morello, Paolo A. Ascierto
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-10 (2020)
Abstract Background PD-1 blocking agents, such as nivolumab, have demonstrated clear anti-tumor effects and clinical benefits in a subset of patients with advanced malignancies. Nonetheless, more efforts are needed to identify reliable biomarkers for
Externí odkaz:
https://doaj.org/article/1d823bbfda724a32aa3ced2ae1f337c9
Autor:
Elisabetta Caiazzo, Ida Cerqua, Roberta Turiello, Maria Antonietta Riemma, Giacomo De Palma, Armando Ialenti, Fiorentina Roviezzo, Silvana Morello, Carla Cicala
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 697 (2022)
Ecto-5′-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory processes by controlling innate and acquired immunity cell functions. We p
Externí odkaz:
https://doaj.org/article/9c7f1405352345f4a50e8388e5517f73
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/4060fe43ea9846b4951c78bf6c6570db
Autor:
Elisabetta Caiazzo, Ida Cerqua, Maria Antonietta Riemma, Roberta Turiello, Armando Ialenti, Jurgen Schrader, Giuseppe Fiume, Carmen Caiazza, Fiorentina Roviezzo, Silvana Morello, Carla Cicala
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The airways are a target tissue of type I allergies and atopy is the main etiological factor of bronchial asthma. A predisposition to allergy and individual response to allergens are dependent upon environmental and host factors. Early studies perfor
Externí odkaz:
https://doaj.org/article/2da775285fde4da3ba03c8b1da7b5268
Autor:
Teresa Amaral, Mariaelena Capone, Gabriele Madonna, Lucia Festino, Domenico Mallardo, Paolo A Ascierto, Piotr Rutkowski, Jason John Luke, Mitchell P Levesque, Roberta Turiello, Elva Morretta, Maria Chiara Monti, Rosa Azzaro, Laurence Imhof, Marc Chevrier, Antje Sucker, Aldo Pinto, Silvana Morello
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Inhibitors of immune checkpoint programmed cell death protein 1 (PD-1) receptor on T cells have shown remarkable clinical outcomes in metastatic melanoma. However, most patients are resistant to therapy. Production of extracellular adenosi
Externí odkaz:
https://doaj.org/article/ca411bc46b9f4db2a7c3cf284f8adfd0
Publikováno v:
Cells, Vol 10, Iss 9, p 2223 (2021)
There is increasing evidence for a link between inflammation and thrombosis. Following tissue injury, vascular endothelium becomes activated, losing its antithrombotic properties whereas inflammatory mediators build up a prothrombotic environment. Pl
Externí odkaz:
https://doaj.org/article/453faab2782d49af83e33f5f036e5d09