Interaction of nitrite with ferric protoglobin from Methanosarcina acetivorans – an interesting model for spectroscopic studies of the haem–ligand interaction

Autor: Roberta Sgammato, Niels Van Brempt, Roy Aerts, Sabine Van Doorslaer, Sylvia Dewilde, Wouter Herrebout, Christian Johannessen

Publikováno v: Dalton Transactions : an international journal of inorganic chemistry

Protoglobin from Methanosarcina acetivorans (MaPgb) is a dimeric globin belonging to the same lineage of the globin superfamily as globin-coupled sensors. A putative role in the scavenging of reactive nitrogen and oxygen species has been suggested as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e4a1045b725cfda4ec76cc659f2c3c
https://doi.org/10.1039/d2dt03252j

The effect of pH and nitrite on the haem pocket of GLB-33, a globin-coupled neuronal transmembrane receptor of Caenorhabditis elegans

Autor: Niels Van Brempt, Roberta Sgammato, Quinten Beirinckx, Dietmar Hammerschmid, Frank Sobott, Sylvia Dewilde, Luc Moens, Wouter Herrebout, Christian Johannessen, Sabine Van Doorslaer

Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1871:140913

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::064220dcb915228e2021b0e5daa2078d
https://doi.org/10.1016/j.bbapap.2023.140913

In Silico Identification and Experimental Validation of Novel Anti-Alzheimer's Multitargeted Ligands from a Marine Source Featuring a '2-Aminoimidazole plus Aromatic Group' Scaffold

Autor: Doriana Desiderio, Pietro Amodeo, Tullio Florio, Rosaria Arcone, Vera Felicità, Margherita Gavagnin Capoggiani, Maria Letizia Ciavatta, Stefano Thellung, Rosa Maria Vitale, Massimo Vassalli, Vincenzo Rispoli, Mariorosario Masullo, Marianna Carbone, Roberta Sgammato, Ernesto Mollo, Claudio Canale

Publikováno v: ACS chemical neuroscience 9 (2018): 1290–1303. doi:10.1021/acschemneuro.7b00416
info:cnr-pdr/source/autori:Vitale RM, Rispoli V, Desiderio D, Sgammato R, Thellung S, Canale C, Vassalli M, Carbone M, Ciavatta ML, Mollo E, Felicità V, Arcone R, Gavagnin Capoggiani M, Masullo M, Florio T, Amodeo P/titolo:In Silico Identification and Experimental Validation of Novel Anti-Alzheimer's Multitargeted Ligands from a Marine Source Featuring a "2-Aminoimidazole plus Aromatic Group" Scaffold/doi:10.1021%2Facschemneuro.7b00416/rivista:ACS chemical neuroscience/anno:2018/pagina_da:1290/pagina_a:1303/intervallo_pagine:1290–1303/volume:9

Multitargeting or polypharmacological approaches, looking for single chemical entities retaining the ability to bind two or more molecular targets, are a potentially powerful strategy to fight complex, multifactorial pathologies. Unfortunately, the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85527109052cee931118d665558aae2
http://hdl.handle.net/11367/69108

Native PAGE to study the interaction between the oncosuppressor p53 and its protein ligands

Autor: Roberta Sgammato, Chiara Punzo, Doriana Desiderio, Anna Lamberti, Ettore Novellino, Alfonso Carotenuto, Gennaro Raimo, Mariorosario Masullo

In the present study, we investigated a new approach for studying the interaction between p53 and MDM2/X (where MDM is murine double minute protein). The method is based on the different mobility between the interacting domains of the oncosuppressor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5dbfac4f952608af5b9e212a156f5a
http://hdl.handle.net/11588/603588