Chronic exposure to interleukin-6 amplifies the response to toll-like receptor ligands: Implication on the pathogenesis of macrophage activation syndrome

Autor: Raffaele Strippoli 1, Francesco Carvello 1, Roberta Scianaro 1, Loredana De Pasquale 1, Marina Vivarelli 1, Stefania Petrini 1, Luisa Bracci-Laudiero 1, 2, Fabrizio De Benedetti 1

Publikováno v: Arthritis and rheumatism (2011).
info:cnr-pdr/source/autori:Strippoli R (1); Carvello F (1); Scianaro R(1); Pasquale LD (1);, Vivarelli M (1); Petrini S (1); Bracci-Laudiero L (1,2); De Benedetti F (1)./titolo:Chronic exposure to interleukin-6 amplifies the response to toll-like receptor ligands: Implication on the pathogenesis of macrophage activation syndrome./doi:/rivista:Arthritis and rheumatism/anno:2011/pagina_da:/pagina_a:/intervallo_pagine:/volume
Pediatric Rheumatology Online Journal, Vol 9, Iss Suppl 1, p P210 (2011)
Pediatric rheumatology online journal 9 (2011): P210. doi:10.1186/1546-0096-9-S1-P210
info:cnr-pdr/source/autori:Raffaele Strippoli 1, Francesco Carvello 1, Roberta Scianaro 1, Loredana De Pasquale 1, Marina Vivarelli 1, Stefania Petrini 1, Luisa Bracci-Laudiero 1,2 and Fabrizio De Benedetti 1/titolo:Chronic exposure to Interleukin-6 amplifies the response to Toll-like receptor ligands: implication on the pathogenesis of macrophage activation syndrome/doi:10.1186%2F1546-0096-9-S1-P210/rivista:Pediatric rheumatology online journal/anno:2011/pagina_da:P210/pagina_a:/intervallo_pagine:P210/volume:9
Pediatric Rheumatology Online Journal

Objective To analyse whether prolonged exposure to IL-6 affects the inflammatory response induced by TLR ligands. Methods IL-6 transgenic (IL-6TG) or wild type mice were stimulated with different TLR ligands; survival, blood cells counts and biochemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33aabf2b87bb7a862d55f359674c3983
http://www.cnr.it/prodotto/i/59254