Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Roberta R Ruela-de-Sousa"'
Autor:
Catarina Rapôso, Paulo Alexandre Miranda Odorissi, Stefania Fioravanti Savioli, Rafaela Chitarra Rodrigues Hell, Gustavo Ferreira Simões, Roberta R Ruela-de-Sousa, Alexandre Leite Rodrigues de Oliveira, Maria Alice da Cruz-Höfling
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107292 (2014)
Severe accidents caused by the "armed" spider Phoneutria nigriventer cause neurotoxic manifestations in victims. In experiments with rats, P. nigriventer venom (PNV) temporarily disrupts the properties of the BBB by affecting both the transcellular a
Externí odkaz:
https://doaj.org/article/b102015418364a4db3a6d7ad3ff767f4
Autor:
Paula A Ferreira, Roberta R Ruela-de-Sousa, Karla C S Queiroz, Ana Carolina S Souza, Renato Milani, Ronaldo Aloise Pilli, Maikel P Peppelenbosch, Jeroen den Hertog, Carmen V Ferreira
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44312 (2012)
The development of multidrug resistance (MDR) limits the efficacy of continuous chemotherapeutic treatment in chronic myelogenous leukemia (CML). Low molecular weight protein tyrosine phosphatase (LMW-PTP) is up-regulated in several cancers and has b
Externí odkaz:
https://doaj.org/article/baf11ada3dda43aab3ca5486a6caa79c
Autor:
Karla C S Queiroz, Renato Milani, Roberta R Ruela-de-Sousa, Gwenny M Fuhler, Giselle Z Justo, Willian F Zambuzzi, Nelson Duran, Sander H Diks, C Arnold Spek, Carmen V Ferreira, Maikel P Peppelenbosch
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45362 (2012)
It is now generally recognised that different modes of programmed cell death (PCD) are intimately linked to the cancerous process. However, the mechanism of PCD involved in cancer chemoprevention is much less clear and may be different between types
Externí odkaz:
https://doaj.org/article/59ad423b04b44b55ba702c93971bd05e
Autor:
Tuanny L Almeida, Timothy M. Willson, Álvaro Lorente-Macías, William J. Zuercher, Reena Zutshi, David H. Drewry, Jonathan M. Elkins, Carrow I. Wells, Cunyu Zhang, Julie E. Pickett, Juanita C. Limas, Opher Gileadi, Alexander Riemen, Alison D. Axtman, Jeanette Gowen Cook, Roberta R. Ruela-de-Sousa, Nirav Kapadia, Rafael M. Couñago
Publikováno v:
ACS Med Chem Lett
[Image: see text] Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual AAK1/BMP2K inhibitors. Optimization furnished a small molecule chemical probe (SGC-AAK1-1, 25) that is potent and selective for AAK1/BMP2K over
Autor:
Rafael M. Couñago, A Riemen, William J. Zuercher, David H. Drewry, Álvaro Lorente-Macías, Juanita C. Limas, Jonathan M. Elkins, Roberta R. Ruela-de-Sousa, Alison D. Axtman, Nirav Kapadia, Reena Zutshi, Cook Jg, Carrow I. Wells, Opher Gileadi, T Almeida, Julie E. Pickett, C. Zhang, Timothy M. Willson
Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual AAK1/BMP2K inhibitors. Optimization of this 3-acylaminoindazole scaffold furnished a small molecule chemical probe (SGC-AAK1-1, 25) that is potent and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c4acd9800821eb7de6feaa56b828d6
https://doi.org/10.26434/chemrxiv.9756785.v1
https://doi.org/10.26434/chemrxiv.9756785.v1
Autor:
F.J. Sorrell, Matthew P. Walker, Timothy M. Willson, A.S. Santiago, Opher Gileadi, James M. Bennett, Oleg Fedorov, Carina Gileadi, Alison D. Axtman, Susanne Müller, Serafin Ds, Michael B. Major, Meagan B. Ryan, Megan J. Agajanian, Rafael M. Couñago, Roberta R. Ruela-de-Sousa, David M. Graham, Nirav Kapadia, P.H.C. Godoi, Alex D. Rabinowitz, David H. Drewry, J.M. Elkins, Carrow I. Wells, William J. Zuercher
β-catenin-dependent WNT signal transduction governs normal development and adult tissue homeostasis. Inappropriate pathway activity mediates a vast array of human diseases, including bone density disorders, neurodegeneration and cancer. Although sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72833d6500a2dea075a8e06501f767c
https://doi.org/10.1101/258632
https://doi.org/10.1101/258632
Autor:
Carina Gileadi, Jonathan M. Elkins, Meagan B. Ryan, Matthew P. Walker, Melissa V. Gammons, James M. Bennett, Timothy M. Willson, David H. Drewry, Alison D. Axtman, Oleg Fedorov, Carrow I. Wells, Rafael M. Couñago, Alex D. Rabinowitz, Michael B. Major, A.S. Santiago, William J. Zuercher, Roberta R. Ruela-de-Sousa, David M. Graham, P.H.C. Godoi, Nirav Kapadia, Opher Gileadi, F.J. Sorrell, Megan J. Agajanian, Susanne Müller, D. Stephen Serafin
Publikováno v:
SSRN Electronic Journal.
β-catenin-dependent WNT signal transduction governs development, tissue homeostasis and a vast array of human diseases. Signal propagation through a WNT-Frizzled/LRP receptor complex requires clathrin-mediated endocytosis (CME). Paradoxically, CME a
Autor:
David H. Drewry, Carrow I. Wells, David M. Graham, Susanne Müller, P.H.C. Godoi, Roberta R. Ruela-de-Sousa, Nirav Kapadia, Matthew P. Walker, Megan J. Agajanian, Alex D. Rabinowitz, Fiona J. Sorrell, Meagan B. Ryan, James M. Bennett, Opher Gileadi, Alison D. Axtman, Timothy M. Willson, Tigist Y. Tamir, Yuko Nakamichi, Rafael M. Couñago, William J. Zuercher, Jonathan M. Elkins, D. Stephen Serafin, Michael B. Major, Melissa V. Gammons, Carina Gileadi, Oleg Fedorov, A.S. Santiago
Publikováno v:
Cell Reports
Summary β-Catenin-dependent WNT signal transduction governs development, tissue homeostasis, and a vast array of human diseases. Signal propagation through a WNT-Frizzled/LRP receptor complex requires proteins necessary for clathrin-mediated endocyt
Autor:
Maikel P. Peppelenbosch, Elmer Hoekstra, Roberta R. Ruela-de-Sousa, Carmen Veríssima Ferreira, Gwenny M. Fuhler, Karin Juliane Pelizzaro-Rocha, Geert J.L.H. van Leenders, Andrew P. Stubbs, A. Marije Hoogland, G. Jenster, Hiroshi Aoyama, Karla C. S. Queiroz
Publikováno v:
European Urology, 69(4), 710-719. Elsevier
European urology, 69(4), 710-719. Elsevier
European urology, 69(4), 710-719. Elsevier
Background: Low-risk patients suffering from prostate cancer (PCa) are currently placed under active surveillance rather than undergoing radical prostatectomy. However, clear parameters for selecting the right patient for each strategy are not availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4cda0365e972eb452ad8db6d783b64
https://pure.eur.nl/en/publications/6eafed88-1fec-4f52-aecd-1d352a268281
https://pure.eur.nl/en/publications/6eafed88-1fec-4f52-aecd-1d352a268281
Autor:
Catarina Rapôso, Karina Fontana, Carmen Veríssima Ferreira, Alexandre Leite Rodrigues de Oliveira, Liana Verinaud, Roberta R. Ruela-de-Sousa, Hiroshi Aoyama, Paulo Alexandre Miranda Odorissi, Maria Alice da Cruz-Höfling
Publikováno v:
Neurochemical Research. 37:1967-1981
Phoneutria nigriventer spider venom (PNV) contains Ca(2+), K(+) and Na(+) channel-acting peptides that affect neurotransmitter release and causes excitotoxicity in PNS and CNS. It has been demonstrated that PNV causes blood-brain barrier (BBB) breakd