Výsledky vyhledávání - "Roberta Poulet"

Nebivolol Induces Nitric Oxide Release in the Heart Through Inducible Nitric Oxide Synthase Activation

Autor: Giuseppe Lembo, Roberta Poulet, Angelo Maffei, Rosa Carangi, Maria Teresa Gentile, Alba Di Pardo, Pierluigi Carullo, Carmine Vecchione

Publikováno v: Hypertension. 50:652-656

Nebivolol is a β1-adrenergic receptor antagonist that also reduces blood pressure by evoking endothelial NO production and vasodilation. We aimed at assessing whether nebivolol induces NO production also in the heart and delineating the molecular me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3698491cca8c496437e50b15d7e801e
https://doi.org/10.1161/hypertensionaha.107.094458

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Characterization of nitric oxide release by nebivolol and its metabolites

Autor: Alessandra Aretini, Angelo Maffei, Giuseppe Lembo, Giuseppe Cifelli, Umberto Bettarini, Roberta Poulet, Carmine Vecchione, Maria Teresa Gentile

Background: Nebivolol is a selective β1-adrenergic receptor antagonist that causes a direct vasodilator effect attributed to the action on vascular nitric oxide (NO). This study aimed to investigate whether nebivolol or its metabolites induces NO pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d0d07551f1969281efac4db47f26ce
http://hdl.handle.net/11386/3877488

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Acute hypertension induces oxidative stress in brain tissues

Autor: Maria Distaso, Alessandra Aretini, Angelo Maffei, Maria G. De Simoni, Roberta Poulet, Luigi Fratta, Giovanni Russo, Giuseppe Lembo, Cinara Echart, Maria Teresa Gentile, Carmine Vecchione

Arterial hypertension is not only a major risk factor for cerebrovascular accidents, such as stroke and cerebral hemorrhage, but is also associated to milder forms of brain injury. One of the main causes of neurodegeneration is the increase in reacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b0eda0c1769696f05c8faabb974048
http://hdl.handle.net/11591/393534

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Selective Rac-1 inhibition protects from diabetes-induced vascular injury

Autor: Lucio Pastore, Antonella Notte, Guido Tarone, Alessandra Aretini, Angelo Maffei, Mauro Sbroggiò, Umberto Bettarini, Roberta Poulet, Luca Iorio, Gennaro Marino, Giuseppe Lembo, Maria Teresa Gentile, Carmine Vecchione, Emilio Hirsch

Diabetes mellitus is a main risk factor for vascular diseases. Vascular injury induced by diabetes mellitus is characterized by endothelial dysfunction attributable to an increased oxidative stress. So far, the molecular mechanisms involved in the va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816f100e8f5a9925c26277f2e7dea3f2
http://hdl.handle.net/2318/38763

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Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma

Autor: Angelo Maffei, Marianna Storto, GianLuca Colussi, Alessandra Aretini, Ornella Azzolino, Mara Brancaccio, Fiorella Altruda, Maria Teresa Gentile, Giuseppe Lembo, Carmine Vecchione, Enrico Patrucco, Guido Tarone, Emilio Hirsch, Lorenzo Silengo, Umberto Bettarini, Roberta Poulet, Mathias P. Wymann, Gennaro Marino, Laura Barberis

Publikováno v: The Journal of Experimental Medicine

Hypertension affects nearly 20% of the population in Western countries and strongly increases the risk for cardiovascular diseases. In the pathogenesis of hypertension, the vasoactive peptide of the renin-angiotensin system, angiotensin II and its G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f636655d96798c238a41a8031d3498cd
https://pubmed.ncbi.nlm.nih.gov/15824082

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Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice

Autor: Carmine Vecchione, Antonella Notte, Tommaso Russo, Nicoletta Potenza, Annamaria Rosica, Giuseppe Lembo, Mario De Felice, Roberto Di Lauro, Assunta De Rienzo, Andrea Affuso, Giuseppe Cifelli, Gabriella De Vita, Roberta Poulet, Lisa Bauer

Ras proteins are highly related GTPases that have key roles in regulating growth, differentiation and tumorigenesis. Gene-targeting experiments have shown that, out of the three mammalian ras genes, only K-ras is essential for normal mouse embryogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abed28bdf497169a6bc3ab2acf507a7
http://hdl.handle.net/11591/166459

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Mechanisms of soluble beta-amyloid impairment of endothelial function

Autor: Alessandra Aretini, Angelo Maffei, Loredana Capobianco, Giuseppe Lembo, Giulio Selvetella, Carmine Vecchione, Roberta Poulet, Maria Teresa Gentile, Gennaro Marino

Alzheimer's disease (AD) has been recently associated with vascular risk factors. beta-amyloid peptides (AbetaP), the main component of senile plaques typical of AD, circulate in soluble globular form in bloodstream. Interestingly, AbetaP is able to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b92b8c659c4c9bc0ca7e0ed3d48f6b
http://hdl.handle.net/11591/393536

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Cooperation between insulin and leptin in the modulation of vascular tone

Autor: Alessandra Aretini, Carmine Vecchione, Giuseppe Lembo, Roberta Poulet, Giacomo Frati, Angelo Maffei, Valentina Trimarco, Giulio Selvetella, Gennaro Marino

High levels of insulin and leptin have been reported in human hypertension, suggesting a role for these metabolic hormones in blood pressure homeostasis. These hormones interact on intermediate metabolism, but nothing is known about their interaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3d605a849125667c219d015a66b611
http://hdl.handle.net/11573/255330

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Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload

Autor: Roberta Poulet, Giuseppe Lembo, Luigi Fratta, Antonella Notte, Simona Guazzone, Emilio Hirsch, Guido Tarone, Marika De Acetis, Gennaro Marino, Fiorella Altruda, Carmine Vecchione, Lorenzo Silengo, Mara Brancaccio

Publikováno v: Nature medicine. 9(1)

Cardiac hypertrophy is an adaptive response to a variety of mechanical and hormonal stimuli, and represents an early event in the clinical course leading to heart failure. By gene inactivation, we demonstrate here a crucial role of melusin, a muscle-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b6eb28bd7c3c1c131ff73efd1ca167
https://pubmed.ncbi.nlm.nih.gov/12514714

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Increased basal nitric oxide release despite enhanced free radical production in hypertension

Autor: Valentina Trimarco, Giuseppe Lembo, Bruno Trimarco, Carmine Vecchione, Salvatore Colella, Luigi Fratta, Giacomo Frati, Roberta Poulet, Angelo Maffei

Introduction Although in hypertension a defect in stimulated nitric oxide (NO) is well established, little is known about basal NO levels. Thus, we measured directly in vessels from normotensive [Wistar-Kyoto (WKY)] rats and spontaneously hypertensiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a0632296f9f6a8cb193bd807411998
http://hdl.handle.net/11573/127638

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