Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Roberta Natália Cestari"'
1
Dissertation/ Thesis
Disposição cinética e transferência placentária do lopinavir e ritonavir em gestantes portadoras do HIV
Autor: Roberta Natália Cestari
Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
O lopinavir/ritonavir (LPV/RTV) são os inibidores de proteases mais utilizados em mulheres grávidas portadoras do vírus da imunodeficiência humana (HIV). O LPV, um fármaco substrato do transportador de efluxo glicoproteína P (P-gp), apresenta u
Externí odkaz: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-31102014-104352/
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2
Systemic Lupus Erythematosus Activity Affects the Sinusoidal Uptake Transporter OATP1B1 Evaluated by the Pharmacokinetics of Atorvastatin
Autor: Roberta Natália Cestari, Glauco Henrique Balthazar Nardotto, Leandro Francisco Pippa, Adriana Rocha, Eduardo Antônio Donadi, Vera Lucia Lanchote, Renê Donizeti Ribeiro de Oliveira, F.F. Souza
Publikováno v: Clinical and Translational Science
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The present study assessed the effect of systemic lupus erythematosus (SLE) activity, a chronic and inflammatory autoimmune disease, on the sinusoidal uptake transporter OATP1B1 using atorvastatin (ATV) as a probe drug. Fifteen healthy subjects, 13 p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d764e7d10827aa8b77baec095177e83
https://doi.org/10.1111/cts.12808
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3
Plasma mevalonic acid exposure as a pharmacodynamic biomarker of fluvastatin/atorvastatin in healthy volunteers
Autor: Renê Donizeti Ribeiro de Oliveira, Juciene Aparecida Caris, Vera Lucia Lanchote, Adriana Rocha, Glauco Henrique Balthazar Nardotto, Roberta Natália Cestari
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Fluvastatin and atorvastatin are inhibitors of hydroxy-methylglutaryl-CoA (HMG-CoA) reductase, the enzyme that converts HMG-CoA to mevalonic acid (MVA). The present study reports for the first time the analysis of mevalonolactone (MVL) in plasma samp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818f8ecccb31d873770d28743e5a101f
https://pubmed.ncbi.nlm.nih.gov/32004772
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4
UPLC-MS/MS method for gemfibrozil determination in plasma with application to a pharmacokinetic study in healthy Brazilian volunteers
Autor: Vera Lucia Lanchote, Adriana Rocha, Roberta Natália Cestari, Renê Donizeti Ribeiro de Oliveira
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Gemfibrozil (GFZ) is a derivative of fibric acid and is used in the treatment of dyslipidemia. GFZ may affect the metabolism of various drugs, including statins, by inhibiting the sinusoidal influx transporter OATP1B1 and also CYP2C9 and CYP2C8 enzym
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1d5683ae9519e19650cca8e36efd2c
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5
Simultaneous analysis of the total plasma concentration of atorvastatin and its five metabolites and the unbound plasma concentration of atorvastatin: application in a clinical pharmacokinetic study of single oral dose
Autor: Adriana Rocha, Roberta Natália Cestari, Vera Lucia Lanchote, Renê Donizeti Ribeiro de Oliveira, Maria Paula Marques
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Atorvastatin (ATV) and its two active metabolites, o-hydroxy atorvastatin acid (o-OH-ATV) and p-hydroxy atorvastatin acid (p-OH-ATV) are responsible for its HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme-A) reductase inhibitory activity, while its corr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbe9893a524a5a271e51a6cf20318be
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6
Effect of systemic lúpus erythematosus on the activity of the sinusoidal influx transporter OATP1B1 evaluated based on the pharmacokinetics and pharmacodynamics of atorvastatin
Autor: Roberta Natália Cestari
Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP
Estudos in vitro, in silico e clínicos mostram que as doenças inflamatórias associadas com o aumento de citocinas resultam em infra-regulação de transportadores e enzimas envolvidas no metabolismo de medicamentos. A atorvastatina é um fármaco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bb214aed58a488af4962bba3a200fb
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7
Disposição cinética e transferência placentária do lopinavir e ritonavir em gestantes portadoras do HIV
Autor: Roberta Natália Cestari
Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP
O lopinavir/ritonavir (LPV/RTV) são os inibidores de proteases mais utilizados em mulheres grávidas portadoras do vírus da imunodeficiência humana (HIV). O LPV, um fármaco substrato do transportador de efluxo glicoproteína P (P-gp), apresenta u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbeb9b4a5bcce601dbb0b3591acfc77
https://doi.org/10.11606/d.60.2014.tde-31102014-104352
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