Zobrazeno 1 - 10 of 42 pro vyhledávání: '"Roberta Montanari"'
1
Akademický článek
Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition
Autor: Davide Capelli, Giulia Cazzaniga, Matteo Mori, Antonio Laghezza, Fulvio Loiodice, Martina Quaglia, Elisa Negro, Fiorella Meneghetti, Stefania Villa, Roberta Montanari
Publikováno v: Biomolecules, Vol 13, Iss 4, p 694 (2023)
PPARγ represents a key target for the treatment of type 2 diabetes and metabolic syndrome. To avoid serious adverse effects related to the PPARγ agonism profile of traditional antidiabetic drugs, a new opportunity is represented by the development
Externí odkaz: https://doaj.org/article/48a2d402920e430a9dc364be84f2f22f
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2
Akademický článek
Surface Plasmon Resonance as a Tool for Ligand Binding Investigation of Engineered GPR17 Receptor, a G Protein Coupled Receptor Involved in Myelination
Autor: Davide Capelli, Chiara Parravicini, Giorgio Pochetti, Roberta Montanari, Caterina Temporini, Marco Rabuffetti, Maria Letizia Trincavelli, Simona Daniele, Marta Fumagalli, Simona Saporiti, Elisabetta Bonfanti, Maria P. Abbracchio, Ivano Eberini, Stefania Ceruti, Enrica Calleri, Stefano Capaldi
Publikováno v: Frontiers in Chemistry, Vol 7 (2020)
The aim of this study was to investigate the potential of surface plasmon resonance (SPR) spectroscopy for the measurement of real-time ligand-binding affinities and kinetic parameters for GPR17, a G protein-coupled receptor (GPCR) of major interest
Externí odkaz: https://doaj.org/article/b4da76b88075492784a514ec8f1c6cc6
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3
Akademický článek
Evaluation of Long–Lasting Antibacterial Properties and Cytotoxic Behavior of Functionalized Silver-Nanocellulose Composite
Autor: Roberta Grazia Toro, Abeer Mohamed Adel, Tilde de Caro, Fulvio Federici, Luciana Cerri, Eleonora Bolli, Alessio Mezzi, Marianna Barbalinardo, Denis Gentili, Massimiliano Cavallini, Mona Tawfik Al-Shemy, Roberta Montanari, Daniela Caschera
Publikováno v: Materials, Vol 14, Iss 15, p 4198 (2021)
Materials possessing long-term antibacterial behavior and high cytotoxicity are of extreme interest in several applications, from biomedical devices to food packaging. Furthermore, for the safeguard of the human health and the environment, it is also
Externí odkaz: https://doaj.org/article/7030a90ec12144d7ba64838ec1e59cca
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4
Akademický článek
Discovery of Novel Chemical Series of OXA-48 β-Lactamase Inhibitors by High-Throughput Screening
Autor: Barbara Garofalo, Federica Prati, Rosa Buonfiglio, Isabella Coletta, Noemi D’Atanasio, Angela Molteni, Daniele Carettoni, Valeria Wanke, Giorgio Pochetti, Roberta Montanari, Davide Capelli, Claudio Milanese, Francesco Paolo Di Giorgio, Rosella Ombrato
Publikováno v: Pharmaceuticals, Vol 14, Iss 7, p 612 (2021)
The major cause of bacterial resistance to β-lactams is the production of hydrolytic β-lactamase enzymes. Nowadays, the combination of β-lactam antibiotics with β-lactamase inhibitors (BLIs) is the main strategy for overcoming such issues. Nevert
Externí odkaz: https://doaj.org/article/c8323392480c40b1bdc34407531be095
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5
Akademický článek
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis
Autor: Gloria Brusotti, Roberta Montanari, Davide Capelli, Giulia Cattaneo, Antonio Laghezza, Paolo Tortorella, Fulvio Loiodice, Franck Peiretti, Bernadette Bonardo, Alessandro Paiardini, Enrica Calleri, Giorgio Pochetti
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract PPAR antagonists are ligands that bind their receptor with high affinity without transactivation activity. Recently, they have been demonstrated to maintain insulin-sensitizing and antidiabetic properties, and they serve as an alternative tr
Externí odkaz: https://doaj.org/article/c974505d82c84893809cac091a690522
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6
Akademický článek
Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy
Autor: Antonio Laghezza, Luca Piemontese, Leonardo Brunetti, Alessia Caradonna, Mariangela Agamennone, Antonella Di Pizio, Giorgio Pochetti, Roberta Montanari, Davide Capelli, Marilena Tauro, Fulvio Loiodice, Paolo Tortorella
Publikováno v: Pharmaceuticals, Vol 13, Iss 6, p 113 (2020)
Matrix metalloproteinases (MMPs) are a family of enzymes involved at different stages of cancer progression and metastasis. We previously identified a novel class of bisphosphonic inhibitors, selective for MMPs crucial for bone remodeling, such as MM
Externí odkaz: https://doaj.org/article/13a3695500ad4a859a1003fa537a1592
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8
Green approach for the fabrication of silver-oxidized cellulose nanocomposite with antibacterial properties
Autor: Daniela Caschera, Roberta G. Toro, Abeer M. Adel, Roberta Montanari, Mona T. Al-Shemy, Fulvio Federici, Tilde de Caro
Publikováno v: Cellulose (Lond.) 27 (2020): 8059–8073. doi:10.1007/s10570-020-03364-7
info:cnr-pdr/source/autori:Caschera D.; Toro R.G.; Federici F.; Montanari R.; de Caro T.; Al-Shemy M.T.; Adel A.M./titolo:Green approach for the fabrication of silver-oxidized cellulose nanocomposite with antibacterial properties/doi:10.1007%2Fs10570-020-03364-7/rivista:Cellulose (Lond.)/anno:2020/pagina_da:8059/pagina_a:8073/intervallo_pagine:8059–8073/volume:27
Herein we present facile and green two-steps method for the fabrication of silver-carboxylated nanocellulose (Ag-ONCs) nanocomposite. Respecting the Circular Economy principle, the ONCs are prepared starting from the treatment of agriculture bagasse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770e5571dc624f17b32b94cfd6c54e3a
https://doi.org/10.1007/s10570-020-03364-7
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9
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex
Autor: Francesca Romana Liberati, Roberta Piacentini, Alessandro Paiardini, Angela Tramonti, Giorgio Giardina, Roberta Lucchi, Serena Rinaldo, Giorgio Pochetti, Roberto Contestabile, Giacomo Parisi, Sharon Spizzichino, Dalila Boi, Francesca Cutruzzolà, Giovanna Boumis, Davide Capelli, Alessio Paone, Roberta Montanari
Publikováno v: The FEBS journal (Online) (2021).
info:cnr-pdr/source/autori:Sharon Spizzichino, Dalila Boi, Giovanna Boumis, Roberta Lucchi, Francesca Romana Liberati, Davide Capelli, Roberta Montanari, Giorgio Pochetti, Roberta Piacentini, Giacomo Parisi, Alessio Paone, Serena Rinaldo, Roberto Contestabile, Alessandro Paiardini, Angela Tramonti, Giorgio Giardina, Francesca Cutruzzolà/titolo:Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex/doi:/rivista:The FEBS journal (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
The FEBS journal
(2021). doi:10.1111/febs.16248
info:cnr-pdr/source/autori:Spizzichino, Sharon; Boi, Dalila; Boumis, Giovanna; Lucchi, Roberta; Liberati, Francesca Romana; Capelli, Davide; Montanari, Roberta; Pochetti, Giorgio; Piacentini, Roberta; Parisi, Giacomo; Paone, Alessio; Rinaldo, Serena; Contestabile, Roberto; Tramonti, Angela; Paiardini, Alessandro; Giardina, Giorgio; Cutruzzolà, Francesca/titolo:Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex/doi:10.1111%2Ffebs.16248/rivista:The FEBS journal (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
De novo thymidylate synthesis is a crucial pathway for normal and cancer cells. Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT1), dihydrofolate reductase (DHFR) and th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d9651953ac1a1098accf515108c1dd
http://hdl.handle.net/11573/1584599
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10
PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc
Autor: Dalila Boi, Fani Souvalidou, Davide Capelli, Federica Polverino, Grazia Marini, Roberta Montanari, Giorgio Pochetti, Angela Tramonti, Roberto Contestabile, Daniela Trisciuoglio, Patrizia Carpinelli, Camilla Ascanelli, Catherine Lindon, Alessandro De Leo, Michele Saviano, Roberto Di Santo, Roberta Costi, Giulia Guarguaglini, Alessandro Paiardini
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13122
International journal of molecular sciences
22 (2021). doi:10.3390/ijms222313122
info:cnr-pdr/source/autori:Boi, Dalila; Souvalidou, Fani; Capelli, Davide; Polverino, Federica; Marini, Grazia; Montanari, Roberta; Pochetti, Giorgio; Tramonti, Angela; Contestabile, Roberto; Trisciuoglio, Daniela; Carpinelli, Patrizia; Ascanelli, Camilla; Lindon, Catherine; De Leo, Alessandro; Saviano, Michele; Di Santo, Roberto; Costi, Roberta; Guarguaglini, Giulia; Paiardini, Alessandro/titolo:Pha-680626 is an effective inhibitor of the interaction between aurora-a and n-myc/doi:10.3390%2Fijms222313122/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
International journal of molecular sciences (Online) (2021).
info:cnr-pdr/source/autori:Fani Souvalidou, Dalila Boi, Davide Capelli, Federica Polverino, Grazia Marini, Roberta Montanari, Giorgio Pochetti, Angela Tramonti, Roberto Contestabile, Daniela Trisciuoglio, Patrizia Carpinelli, Camilla Ascanelli, Catherine Lindon, Alessandro De Leo, Michele Saviano, Roberto Di Santo, Roberta Costi, Giulia Guarguaglini, Alessandro Paiardini/titolo:PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc/doi:/rivista:International journal of molecular sciences (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
International Journal of Molecular Sciences, Vol 22, Iss 13122, p 13122 (2021)
Neuroblastoma is a severe childhood disease, accounting for ~10% of all infant cancers. The amplification of the MYCN gene, coding for the N-Myc transcriptional factor, is an essential marker correlated with tumor progression and poor prognosis. In n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c541ceaed1ca2e7f611a496ae8dd92dd
http://europepmc.org/articles/PMC8658095
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