Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Roberta Maestro"'
Autor:
Anna Maria Frezza, Silvia Stacchiotti, Frederic Chibon, Jean‐Michelle Coindre, Antoine Italiano, Cleofe Romagnosa, Silvia Bagué, Angelo Paolo Dei Tos, Luca Braglia, Emanuela Palmerini, Vittorio Quagliuolo, Javier Martin Broto, Antonio Lopez Pousa, Giovanni Grignani, Antonella Brunello, Jean‐Yves Blay, Robert Diaz Beveridge, Iwona Lugowska, Tom Lesluyes, Roberta Maestro, Franco Domenico Merlo, Paolo Giovanni Casali, Alessandro Gronchi
Publikováno v:
Cancer Medicine, Vol 12, Iss 2, Pp 1350-1357 (2023)
Abstract Background The Complexity INdex in SARComas (CINSARC) is a transcriptional signature derived from the expression of 67 genes involved in mitosis control and chromosome integrity. This study aims to assess CINSARC value of in an independent s
Externí odkaz:
https://doaj.org/article/c40f99d4dfaa49b68f9028cd3bb23f20
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9916 (2023)
Germline inactivating mutations in the BRCA1 gene lead to an increased lifetime risk of ovarian and breast cancer (BC). Most BRCA1-associated BC are triple-negative tumors (TNBC), aggressive forms of BC characterized by a lack of expression of estrog
Externí odkaz:
https://doaj.org/article/ce78285319314bdfb99e742960dc003d
Autor:
Yongmei Zhao, Li Tai Fang, Tsai-wei Shen, Sulbha Choudhari, Keyur Talsania, Xiongfong Chen, Jyoti Shetty, Yuliya Kriga, Bao Tran, Bin Zhu, Zhong Chen, Wanqiu Chen, Charles Wang, Erich Jaeger, Daoud Meerzaman, Charles Lu, Kenneth Idler, Luyao Ren, Yuanting Zheng, Leming Shi, Virginie Petitjean, Marc Sultan, Tiffany Hung, Eric Peters, Jiri Drabek, Petr Vojta, Roberta Maestro, Daniela Gasparotto, Sulev Kõks, Ene Reimann, Andreas Scherer, Jessica Nordlund, Ulrika Liljedahl, Jonathan Foox, Christopher E. Mason, Chunlin Xiao, Huixiao Hong, Wenming Xiao
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-14 (2021)
Measurement(s) Somatic Mutation Analysis Technology Type(s) whole genome sequencing • Whole Exome Sequencing Factor Type(s) sequencing platform • sample prepration • library preparation • bioinformatics method Sample Characteristic - Organism
Externí odkaz:
https://doaj.org/article/df99660883fb470bb2307f5ae2b58917
Autor:
Clara Perrone, Silvia Pomella, Matteo Cassandri, Michele Pezzella, Giuseppe Maria Milano, Marta Colletti, Cristina Cossetti, Giulia Pericoli, Angela Di Giannatale, Emmanuel de Billy, Maria Vinci, Stefania Petrini, Francesco Marampon, Concetta Quintarelli, Riccardo Taulli, Josep Roma, Soledad Gallego, Simona Camero, Paolo Mariottini, Manuela Cervelli, Roberta Maestro, Lucio Miele, Biagio De Angelis, Franco Locatelli, Rossella Rota
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma. The Fusion-Positive (FP) subtype expresses the chimeric protein PAX3-FOXO1 (P3F) while the Fusion-Negative (FN) is devoid of any gene translocation. FP-RMS and metastatic FN-RMS are
Externí odkaz:
https://doaj.org/article/ee3525baf2b04329b1397817076f26b7
Autor:
Valentina Conti, Manuela Cominelli, Valentina Pieri, Alberto L. Gallotti, Ilaria Pagano, Matteo Zanella, Stefania Mazzoleni, Flavia Pivetta, Monica Patanè, Giulia M. Scotti, Ignazio S. Piras, Bianca Pollo, Andrea Falini, Alessio Zippo, Antonella Castellano, Roberta Maestro, Pietro L. Poliani, Rossella Galli
Publikováno v:
JCI Insight, Vol 6, Iss 23 (2021)
Medulloblastoma (MB), one of the most malignant brain tumors of childhood, comprises distinct molecular subgroups, with p53 mutant sonic hedgehog–activated (SHH-activated) MB patients having a very severe outcome that is associated with unfavorable
Externí odkaz:
https://doaj.org/article/50c5ba30db8f477f8318eacf4e00e7f0
Autor:
Anastasia Dell’Elice, Giulia Cini, Mara Fornasarig, Franco Armelao, Daniela Barana, Francesca Bianchi, Guido Claudio Casalis Cavalchini, Antonella Maffè, Isabella Mammi, Monica Pedroni, Antonio Percesepe, Italo Sorrentini, Mariagrazia Tibiletti, Roberta Maestro, Michele Quaia, Alessandra Viel
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 12, Pp n/a-n/a (2021)
Abstract Backgrounds MUTYH‐associated polyposis (MAP) is an autosomal recessive disease caused by biallelic pathogenic variants (PV) of the MUTYH gene. The aim of this study was to investigate the genetic causes of unexplained polyposis patients wi
Externí odkaz:
https://doaj.org/article/99c3afe8a4b24cbf9fe7fbe90e0bfcc3
Autor:
Elisa Del Savio, Roberta Maestro
Publikováno v:
Cells, Vol 11, Iss 17, p 2626 (2022)
Epithelioid sarcoma (ES) is a very rare and aggressive mesenchymal tumor of unclear origin and uncertain lineage characterized by a prevalent epithelioid morphology. The only recurrent genetic alteration reported in ES as yet is the functional inacti
Externí odkaz:
https://doaj.org/article/f8b4b55d85a742c094b4ba448dcbdc39
Autor:
Daniela Gasparotto, Marta Sbaraglia, Sabrina Rossi, Davide Baldazzi, Monica Brenca, Alessia Mondello, Federica Nardi, Dominga Racanelli, Matilde Cacciatore, Angelo Paolo Dei Tos, Roberta Maestro
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
Intratumoral immune infiltrate was recently reported in gastrointestinal stromal tumors (GISTs). However, the tumor-intrinsic factors that dictate GIST immunogenicity are still largely undefined. To shed light on this issue, a large cohort (82 sample
Externí odkaz:
https://doaj.org/article/7b5685449a644f5298b7ad393fad87f9
Autor:
Manuela Santarosa, Roberta Maestro
Publikováno v:
Cancers, Vol 13, Iss 24, p 6328 (2021)
Cell-to-cell adhesion is a key element in epithelial tissue integrity and homeostasis during embryogenesis, response to damage, and differentiation. Loss of cell adhesion and gain of mesenchymal features, a phenomenon known as epithelial to mesenchym
Externí odkaz:
https://doaj.org/article/1086cec595f14f37b9aa41e15884c6c6
Autor:
Valentina Damiano, Paola Spessotto, Giulia Vanin, Tiziana Perin, Roberta Maestro, Manuela Santarosa
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Autophagy is an intracellular catabolic process that is increasingly being recognized as a crucial factor in several human diseases including cancers. Mounting evidence suggests that autophagy allows tumor cells to overcome otherwise fatal stresses a
Externí odkaz:
https://doaj.org/article/c65e64ca85f84d85aba4c5f43f87d1bc