Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Roberta M. Johnke"'
Publikováno v:
Future Oncology. 10:2345-2357
ABSTRACT Only two radioprotective compounds, amifostine and palifermin, currently have the US FDA approval for use in radiation therapy. However, several agents have been reported that show therapeutic promise. Many of these agents are free radical s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68274afee0b058bcdbab587cd421d0f
https://doi.org/10.2217/fon.14.175
https://doi.org/10.2217/fon.14.175
Autor:
Roberta M. Johnke, William T.C. Yuh, Simon S. Lo, Guang Jia, Zhibin Huang, Nina A. Mayr, Jian Z. Wang
Publikováno v:
Medical Physics. 39:224-230
Purpose: It has been conventionally assumed that the repair rate for sublethal damage (SLD) remains constant during the entire radiation course. However, increasing evidence from animal studies suggest that this may not the case. Rather, it appears t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4b61f1c7150d8d9f60887a0a518dbf6
https://doi.org/10.1118/1.3666760
https://doi.org/10.1118/1.3666760
Autor:
S Benhabib, Ron R. Allison, C. Sheng, Roberta M. Johnke, Tao Wang, Tung-Kwang Lee, Kevin O'Brien, W. Wang
Publikováno v:
The Journal of Alternative and Complementary Medicine. 16:561-567
Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced formation of reactive oxygen species (ROS) that attack DNA leading to cell death. Because of the diversity of IR applied in medicine, agriculture, industry, and the gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8b83257e86f8843f4749130666c799
https://doi.org/10.1089/acm.2009.0590
https://doi.org/10.1089/acm.2009.0590
Autor:
C. Sheng, Tao Wang, Ron R. Allison, Tung-Kwang Lee, Roberta M. Johnke, Kevin O'Brien, W. Wang
Publikováno v:
The Open Nuclear Medicine Journal. 1:1-8
The multifold bioactive medicinal properties of ginseng have been closely linked to its antioxidative ability, which is related to its ginsenoside content. Since the key mechanism of radiation-induced cell death and tissue damage is the generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a4e7e181d16afbc8bc2e4630495459
https://doi.org/10.2174/1876388x00901010001
https://doi.org/10.2174/1876388x00901010001
Autor:
Angelica L. Diaz, Tung-Kwang Lee, Ron R. Allison, W. Wang, Tao Wang, Roberta M. Johnke, Kevin O'Brien
Publikováno v:
Phytotherapy Research. 22:1614-1622
One of the major mechanisms of ionizing radiation (IR)-induced cell death is the generation of reactive oxygen species (ROS) that attack cellular DNA (McBride et al, 2004; Moller and Loft, 2004; Moulder, 2002). For cancer patients receiving radiother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e624511130be05598df3a10ada6219
https://doi.org/10.1002/ptr.2533
https://doi.org/10.1002/ptr.2533
Publikováno v:
Mutagenesis. 20:237-243
A majority of potential radioprotective synthetic compounds have demonstrated limited clinical application owing to their inherent toxicity, and thus, the seeking of naturally occurring herbal products, such as ginseng, for their radioprotective capa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cfed5d66acf3ca7d761dee86103f11
https://doi.org/10.1093/mutage/gei041
https://doi.org/10.1093/mutage/gei041
Autor:
Wade Naziri, M. J. Evans, Larry Dobbs, Farid E Ahmed, Roberta M. Johnke, Gordon P. Flake, Patricia S. Stockton, Ron R. Allison, Dennis R. Sinar, Kovacs Cj, Donald T. Lysle, Stephanie I. James
Publikováno v:
Digestive Diseases and Sciences. 49:1889-1898
In order to diagnose colon cancer at an earlier, more localized stage, there is a need to develop diagnostic markers (genes) which can detect early patterns of gene expression in exfoliated colonocytes shed in the stool during routine screening for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c2f000281a3cbfb336e9363436e2a7
https://doi.org/10.1007/s10620-004-9589-9
https://doi.org/10.1007/s10620-004-9589-9
Autor:
Stephanie I. James, Roberta M. Johnke, Barbara M. Daly, Farid E Ahmed, M. J. Evans, Dennis R. Sinar, Wade Naziri, Donald T. Lysle, Ron R. Allison, Kovacs Cj, Larry Dobbs
Publikováno v:
Analytical Biochemistry. 332:394-397
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d0fba60a6bdcc9761e81fed87dd677
https://doi.org/10.1016/j.ab.2004.05.018
https://doi.org/10.1016/j.ab.2004.05.018
Autor:
B.M. Daly, M. J. Evans, G.S. Eaves, Kovacs Cj, Ulf Karlsson, Tung-Kwang Lee, Ron R. Allison, L.M. Biggs, Roberta M. Johnke
Publikováno v:
Cytokine. 23:151-163
As a result of the association between ionizing irradiation and the induction of inflammatory and fibrogenic cytokines, circulating levels of IL-1alpha, macrophage colony stimulating factor (M-CSF) and TGFbeta were measured in a group of 37 patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59548c90eb20b828f953ee3daff0a6e
https://doi.org/10.1016/s1043-4666(03)00185-6
https://doi.org/10.1016/s1043-4666(03)00185-6
Publikováno v:
Journal of Leukocyte Biology. 51:53-58
Recombinant human interleukin 1 (IL-1) administered as a “priming” agent 24 h prior to hematopoietically lethal doses of total body irradiation (TBI) confers radioprotection to normal G57B1/6 (B6) mice, but not to B6 tumor-bearing animals (TBAs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1b9fd21a7008edc371cd2fe635c684
https://doi.org/10.1002/jlb.51.1.53
https://doi.org/10.1002/jlb.51.1.53