Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Roberta L. McKee"'
Autor:
Chih‐Tai Leu, Michael Chorev, Eliahu Roubini, Roberta L. McKee, Michael P. Caulfield, Jay J. Levy, Michael Rosenblatt, Susan W. Gibbons
Publikováno v:
International Journal of Peptide and Protein Research. 40:445-455
In an effort to design a mild, non-oxidative and site-specific means of radiolabeling bioactive molecules we have employed maleimido-sulfhydryl chemistry to produce bioactive hormone radioligands. We have prepared two novel radioiodolabeled reagents,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e19d9246f4abe44d105146e3ebf2c0
https://doi.org/10.1111/j.1399-3011.1992.tb00323.x
https://doi.org/10.1111/j.1399-3011.1992.tb00323.x
Autor:
Michael Chorev, Mark E. Goldman, Michael P. Caulfield, Eliahu Roubini, Jane E. Reagan, Susan W. Gibbons, Roberta L. McKee, Michael Rosenblatt
Publikováno v:
Peptides. 12:57-62
Lysine occupies position 13 in the parathyroid hormone (PTH) antagonist, [Nle8,18,Tyr34]bPTH(7-34)NH2. Acylation of the epsilon-amino group in lysine 13 by a hydrophobic moiety is well tolerated in terms of bioactivity: the analog [Nle8,18, D-Trp12,L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de21b097485f4d04764449094b962de8
https://doi.org/10.1016/0196-9781(91)90167-n
https://doi.org/10.1016/0196-9781(91)90167-n
Autor:
MICHAEL P. CAULFIELD, ROBERTA L. McKEE, MARK E. GOLDMAN, LE T. DUONG, JOHN E. FISHER, C. THOMAS GAY, PATRICIA A. DEHAVEN, JAY J. LEVY, ELIAHU ROUBINI, RUTH F. NUTT, MICHAEL CHOREV, MICHAEL ROSENBLATT
Publikováno v:
Endocrinology. 127:83-87
Previous studies examining the interaction of PTH and PTH-related protein (PTHrP) with target tissue have for the most part emphasized the similarity between the two hormones in binding to and activating receptors. This observation that two peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acfed5e2397c2ec78e77e101002356e
https://doi.org/10.1210/endo-127-1-83
https://doi.org/10.1210/endo-127-1-83
Publikováno v:
Endocrinology. 127:76-82
In the design and biological evaluation of PTH antagonists, certain analogs, although antagonists in vitro, possess partial agonist properties in vivo that preclude their utility as antagonists. In an effort to identify weak agonism of PTH analogs, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1f65b28bcbc70a187b2980ae6e208d
https://doi.org/10.1210/endo-127-1-76
https://doi.org/10.1210/endo-127-1-76
Autor:
Gideon A. Rodan, Michael Rosenblatt, Noboro Horiuchi, John E. Fisher, Michael P. Caulfield, David D. Thompson, Jay J. Levy, J. Gregory Seedor, Thomas L. Clemens, Roberta L. McKee, Mark E. Goldman, Mark A. Thiede
Publikováno v:
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 17:633-637
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ef08ab49c0a31a9b75b05c042865ec
https://doi.org/10.1016/0883-2897(90)90076-d
https://doi.org/10.1016/0883-2897(90)90076-d
Publikováno v:
Endocrinology. 131(4)
While abundant information is available characterizing PTH receptor properties in other species, data on human PTH receptors is very limited. We have been interested in the possibility that tissue-specific differences among human PTH receptors (i.e.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f356a35a6beb8ffebaf8518c2160d618
https://pubmed.ncbi.nlm.nih.gov/1327716
https://pubmed.ncbi.nlm.nih.gov/1327716
Autor:
Michael Chorev, Michael P. Caulfield, Eliahu Roubini, Roberta L. McKee, Susan W. Gibbons, Jay J. Levy, Michael Rosenblatt
Publikováno v:
Peptides ISBN: 9789401050050
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eaeaac1412ffe2784a7e4d08aa1bb8a
https://doi.org/10.1007/978-94-011-2264-1_216
https://doi.org/10.1007/978-94-011-2264-1_216
Autor:
Michael P. Caulfield, Roberta L. McKee, Susan W. Gibbons, Jay J. Levy, Ruth F. Nutt, Michael Rosenblatt
Publikováno v:
Peptides ISBN: 9789401050050
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ea6fba64745933a518aea82a8d94645
https://doi.org/10.1007/978-94-011-2264-1_366
https://doi.org/10.1007/978-94-011-2264-1_366
Autor:
Michael P. Caulfield, Roberta L. McKee, John E. Fisher, Noboru Horiuchi, David D. Thompson, Sevgi B. Rodan, Mark A. Thiede, Jay J. Levy, Ruth F. Nutt, Thomas L. Clemens, Gideon A. Rodan
Publikováno v:
ACS Symposium Series ISBN: 9780841218864
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::435aae715c8350b2d0fad7fd0503571e
https://doi.org/10.1021/bk-1991-0444.ch016
https://doi.org/10.1021/bk-1991-0444.ch016
Autor:
Roberta L. McKee, Michael P. Caulfield, Nagana A. Goud, Jay J. Levy, John E. Fisher, Michael Rosenblatt, Patrica A. Dehaven, Elizabeth Huelar, Lynn H. Caporale, Susan W. Gibbons, John A. Rodkey, Mustaqim M. Syed, Carl D. Bennett, Harri G. Ramjit, Rajeswari A. Goud
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 6(8)
We have chemically synthesized the full-length, 84 amino acid, human parathyroid hormone (hPTH) on a greater than 100 mg scale by the Merrifield solid-phase technique of stepwise peptide synthesis using a benzhydrylamine support. The peptide was puri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f5d5310c4612cecad078f6c02f2191
https://pubmed.ncbi.nlm.nih.gov/1664643
https://pubmed.ncbi.nlm.nih.gov/1664643