Výsledky vyhledávání - "Roberta Kamin-Lewis"

Akademický článek

Self-protection of individual CD4+ T cells against R5 HIV-1 infection by the synthesis of anti-viral CCR5 ligands.

Autor: Yongjun Guan, Sayed Abdelwahab, Roberta Kamin-Lewis, Anthony L DeVico, George K Lewis

Publikováno v: PLoS ONE, Vol 3, Iss 10, p e3481 (2008)

It is well established that paracrine secretion of anti-viral CCR5 ligands by CD8+ and CD4+ T cells can block the infection of activated CD4+ T cells by R5 and dual-tropic isolates of HIV-1. By contrast, because CD4+ T cells can be infected by HIV-1

Externí odkaz: https://doaj.org/article/75e9c4b37a814b788ce5f8a598889d1c

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Epitope target structures of Fc-mediated effector function during HIV-1 acquisition

Autor: Marzena Pazgier, Anthony L. DeVico, George K. Lewis, Roberta Kamin-Lewis, Yongjun Guan, Mohammad M. Sajadi

Publikováno v: Current Opinion in HIV and AIDS. 9:263-270

This review analyzes recent studies suggesting that highly conserved epitopes in the HIV-1 Env trimer are targets of potentially protective nonneutralizing antibodies that mediate antibody-dependent cellular cytotoxicity.Recent studies in both non-hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c26507af8801cc34c0eba7a5b7fa5e
https://doi.org/10.1097/coh.0000000000000055

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Identification and Characterization of an Immunogenic Hybrid Epitope Formed by both HIV gp120 and Human CD4 Proteins

Autor: George K. Lewis, James E. Robinson, Rachita Salkar, Yongjun Guan, Brian Taylor, Sani Ibrahim, Roberta Kamin-Lewis, Timothy R. Fouts, Anthony L. DeVico

Publikováno v: Journal of Virology. 85:13097-13104

Certain antibodies from HIV-infected humans bind conserved transition state (CD4 induced [CD4i]) domains on the HIV envelope glycoprotein, gp120, and demonstrate extreme dependence on the formation of a gp120-human CD4 receptor complex. The epitopes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a67c59c1c4dc5abdcad8c77947b2bfc
https://doi.org/10.1128/jvi.05072-11

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Discordant memory B cell and circulating anti-Env antibody responses in HIV-1 infection

Autor: George K. Lewis, Roberta Kamin-Lewis, Timothy R. Fouts, Robert C. Gallo, Robert R. Redfield, Zhixin Zhang, Anthony L. DeVico, Yongjun Guan, Mohammad M. Sajadi, Anthony Dimitrov

Publikováno v: Proceedings of the National Academy of Sciences

Long-lived memory B cells (B Mem ) provide an archive of historic Ab responses. By contrast, circulating Abs typically decline once the immunogen is cleared. Consequently, circulating Abs can underestimate the nature of cognate humoral immunity. On t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43497b5fc15861dbb147e6c66d7efe2
https://doi.org/10.1073/pnas.0813392106

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Development of an oral prime–boost strategy to elicit broadly neutralizing antibodies against HIV-1

Autor: George K. Lewis, Roberta Kamin-Lewis, Mohamed T. Shata, Timothy R. Fouts, Anthony L. DeVico, David M. Hone

Publikováno v: Vaccine. 20:1968-1974

Given the increasing incidence of HIV-1 infection world-wide, an affordable, effective vaccine is probably the only way that this virus will be contained. Accordingly, our group is developing an oral prime–boost strategy with the primary goal of el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c02f005e2d0fd5395b43e6768ee140
https://doi.org/10.1016/s0264-410x(02)00080-4

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Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2014, 88 (21), pp.12895-12906. ⟨10.1128/JVI.02194-14⟩
Journal of Virology, 2014, 88 (21), pp.12895-12906. ⟨10.1128/JVI.02194-14⟩

The RV144 vaccine trial implicated epitopes in the C1 region of gp120 (A32-like epitopes) as targets of potentially protective antibody-dependent cellular cytotoxicity (ADCC) responses. A32-like epitopes are highly immunogenic, as infected or vaccina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b363df609305a6033fb6fdb88b393fe9
https://pubmed.ncbi.nlm.nih.gov/25165110

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Perforin-low memory CD8+cells are the predominant T cells in normal humans that synthesize the β-chemokine macrophage inflammatory protein-1β

Autor: Anthony L. DeVico, Sayed F. Abdelwahab, Roberta Kamin-Lewis, George K. Lewis, Amanda E. Baker, Robert C. Gallo, Christine Trang

Publikováno v: Proceedings of the National Academy of Sciences. 98:9283-9288

The synthesis of antiviral β-chemokines has joined cytolysis as a potential mechanism for the control of HIV-1 infection by CD8+T cells. Recent evidence suggests that these two effector functions can diverge in some individuals infected with HIV-1;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d5077eaf2f46b9af33630018f68b51
https://doi.org/10.1073/pnas.161298998

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Absence of High-Affinity Binding Sites for Interferon α/β in Variant Murine CD4+T Lymphocytes Not Expressing the T Cell Antigen Receptor

Autor: Connie R. Faltynek, M. Tarek Shata, Roberta Kamin-Lewis, George K. Lewis

Publikováno v: Journal of Interferon & Cytokine Research. 15:291-296

The T cell antigen receptor complex (CD3/Ti) plays a role in specific antigen recognition as well as in signal transduction, with its surface expression required for the function of several other structurally distinct receptor systems, including CD2,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2798734b439940cc47299ee3f6bb08b
https://doi.org/10.1089/jir.1995.15.291

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