Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Roberta J, Melander"'
Autor:
Chang Liu, Hua Zhang, Xian Peng, Meghan S. Blackledge, Robert E. Furlani, Haoting Li, Zhaoming Su, Roberta J. Melander, Christian Melander, Suzanne Michalek, Hui Wu
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Antibiotic tolerance within a biofilm community presents a serious public health challenge. Here, we report the identification of a 2-aminoimidazole derivative that inhibits biofilm formation by two pathogenic Gram-positive bacteria, Strepto
Externí odkaz:
https://doaj.org/article/343e3b9a42f041ec8cbd721edec050a8
Autor:
Ashley N. Crotteau, Veronica B. Hubble, Santiana A. Marrujo, Anne E. Mattingly, Roberta J. Melander, Christian Melander
Publikováno v:
Antibiotics, Vol 12, Iss 11, p 1563 (2023)
In 2019, five million deaths associated with antimicrobial resistance were reported by The Centers for Disease Control and Prevention (CDC). Acinetobacter baumannii, a Gram-negative bacterial pathogen, is among the list of urgent threats. Previously,
Externí odkaz:
https://doaj.org/article/aae56fb03b6846dc8796944a36dc7b9d
Autor:
Kenneth I. Onyedibe, Ansley M. Nemeth, Neetu Dayal, Richard D. Smith, Jones Lamptey, Robert K. Ernst, Roberta J. Melander, Christian Melander, Herman O. Sintim
Publikováno v:
ACS Infectious Diseases. 9:283-295
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4350211a22995bb80c563fd8565afd4
https://doi.org/10.1021/acsinfecdis.2c00417
https://doi.org/10.1021/acsinfecdis.2c00417
Autor:
Haoting Li, Anne E. Mattingly, Richard D. Smith, Roberta J. Melander, Robert K. Ernst, Christian Melander
Publikováno v:
RSC Medicinal Chemistry. 14:247-252
Multidrug resistant (MDR) bacterial infections have become increasingly common, leading clinicians to rely on last-resort antibiotics such as colistin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74de9dec81ec2929735ac9c4e09e5d67
https://doi.org/10.1039/d2md00370h
https://doi.org/10.1039/d2md00370h
Autor:
Alexander W. Weig, Patrick M. O'Conner, Jakub M. Kwiecinski, Orry M. Marciano, Angelica Nunag, Andrew T. Gutierrez, Roberta J. Melander, Alexander R. Horswill, Christian Melander
Publikováno v:
Organic & Biomolecular Chemistry. 21:3373-3380
Several analogues of the Staphylococcus aureus ArlRS inhibitor 3,4′-dimethoxyflavone were identified as more potent than the parent, in addition to one compound that suppresses oxacillin resistance in methicillin resistant S. aureus (MRSA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ee3dc0225d47669bf994c804878a68
https://doi.org/10.1039/d3ob00123g
https://doi.org/10.1039/d3ob00123g
Autor:
Stack, Elizabeth I. Harper, Michael D. Siroky, Tyvette S. Hilliard, Gena M. Dominique, Catherine Hammond, Yueying Liu, Jing Yang, Veronica B. Hubble, Danica J. Walsh, Roberta J. Melander, Christian Melander, Matthew J. Ravosa, M. Sharon
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9804
Ovarian cancer is the sixth leading cause of cancer-related death in women, and both occurrence and mortality are increased in women over the age of 60. There are documented age-related changes in the ovarian cancer microenvironment that have been sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::23766323026e5f1bcbe62d2e60ab833b
Autor:
Morgan E. Milton, Bradley M. Minrovic, Danni L. Harris, Brian Kang, David Jung, Caleb P. Lewis, Richele J. Thompson, Roberta J. Melander, Daina Zeng, Christian Melander, John Cavanagh
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
2-aminoimidazole (2-AI) compounds inhibit the formation of bacterial biofilms, disperse preformed biofilms, and re-sensitize multidrug resistant bacteria to antibiotics. 2-AIs have previously been shown to interact with bacterial response regulators,
Externí odkaz:
https://doaj.org/article/082ce43dccd94bc0a0d952be55b3fb04
Publikováno v:
Bioorganicmedicinal chemistry letters. 80
Gram-negative bacteria are intrinsically resistant to many classes of antibiotics, predominantly due to the impermeability of the outer membrane and the presence of efflux pumps. Small molecule adjuvants that circumvent these resistance mechanisms ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bd169b5ad6ae162739d4fa9b61ee63
https://pubmed.ncbi.nlm.nih.gov/36566797
https://pubmed.ncbi.nlm.nih.gov/36566797
Autor:
Albert B Jeon, Andrés Obregón-Henao, David F Ackart, Brendan K Podell, Juan M Belardinelli, Mary Jackson, Tuan V Nguyen, Meghan S Blackledge, Roberta J Melander, Christian Melander, Benjamin K Johnson, Robert B Abramovitch, Randall J Basaraba
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180925 (2017)
There is an urgent need to develop new drug treatment strategies to control the global spread of drug-sensitive and multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis). The ß-lactam class of antibiotics is among the safest and most wide
Externí odkaz:
https://doaj.org/article/13b71f62b38642b8ae75712bb88ac78d
Autor:
Kittipan Siwawannapong, Ansley M. Nemeth, Roberta J. Melander, Jie Rong, Jonathan R. Davis, Masahiko Taniguchi, Morgan E. Carpenter, Jonathan S. Lindsey, Christian Melander
Publikováno v:
ChemMedChem. 17
Multidrug resistant (MDR) bacteria are an increasing public health problem. One promising alternative to the development of new antibiotics is the use of antibiotic adjuvants, which would allow the continued use of FDA-approved antibiotics that have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adec02dbe2d6b2ef95f9a431a6336f9d
https://doi.org/10.1002/cmdc.202200286
https://doi.org/10.1002/cmdc.202200286