Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Roberta Ferraldeschi"'
Autor:
Carolina Fazio, Alessia Covre, Ornella Cutaia, Maria Fortunata Lofiego, Patrizia Tunici, Carla Chiarucci, Sara Cannito, Gianluca Giacobini, James N. Lowder, Roberta Ferraldeschi, Pietro Taverna, Anna Maria Di Giacomo, Sandra Coral, Michele Maio
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
DNA hypomethylating agents (DHAs) play a well-acknowledged role in potentiating the immunogenicity and the immune recognition of neoplastic cells. This immunomodulatory activity of DHAs is linked to their ability to induce or to up-regulate on neopla
Externí odkaz:
https://doaj.org/article/19f88e57b7774091b03a9ce88cec240f
Publikováno v:
Pharmaceuticals, Vol 3, Iss 4, Pp 1122-1138 (2010)
Tamoxifen remains a cornerstone of treatment for patients with oestrogen-receptor-positive breast cancer. Tamoxifen efficacy depends on the biotransformation, predominantly via the cytochrome P450 2D6 (CYP2D6) isoform, to the active metabolite endoxi
Externí odkaz:
https://doaj.org/article/429861c767f746bd80b3fd168108a438
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary tables 1-6 summarise the kinase panel screen data (1) mouse PK parameters (2) and further details of the anti-tumour activity (5) conferred by ASTX029, plus details of cell lines used in this study (3 and 4) and further details of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c83a97aa3dd2ed35fbdc9ef36e9bb5
https://doi.org/10.1158/1535-7163.22521489.v1
https://doi.org/10.1158/1535-7163.22521489.v1
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary figures 1-7 show the effects of AST029 on ERK signalling in RAS-mutant cell lines (1) and tumour xenograft tissue (3), ASTX029 plasma PK linearity (2), ASTX029 activity in a cell line panel showing MAPK mutation status (4) the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185aef78c19fca4a606a8b2c178f1341
https://doi.org/10.1158/1535-7163.22521498.v1
https://doi.org/10.1158/1535-7163.22521498.v1
Autor:
Udai Banerji, Michelle D. Garrett, Florence I. Raynaud, Karen E. Swales, Sarah Mellor, Gavin Halbert, Stephanie Traub, Paul Jones, Victoria Sanz-Moreno, Oscar Maiques, Roberta Ferraldeschi, Simone Jueliger, Shaun Decordova, Ruth Ruddle, Alvaro H. Ingles Garces, Jessica S. Brown, Joaquin Mateo, Dionysis Papadatos-Pastos, Rajiv Kumar, Robert McLeod
Purpose:AT13148 is an oral AGC kinase inhibitor, which potently inhibits ROCK and AKT kinases. In preclinical models, AT13148 has been shown to have antimetastatic and antiproliferative activity.Patients and Methods:The trial followed a rolling six d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a333c1f82c5ff3931176d17bb6ff2c
https://doi.org/10.1158/1078-0432.c.6529065.v1
https://doi.org/10.1158/1078-0432.c.6529065.v1
Autor:
Anthony W. Tolcher, Simone Jueliger, Xiang Yao Su, Aram Oganesian, Harold Keer, Roberta Ferraldeschi, Alain C. Mita, Michael S. Gordon, Kyriakos P. Papadopoulos, Patricia M. LoRusso, Monica M. Mita
Table S1 shows dose levels of ASTX660 by cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17cb142d4444da2bddab42834d5dc043
https://doi.org/10.1158/1078-0432.22472783
https://doi.org/10.1158/1078-0432.22472783
Autor:
Johann S. de Bono, Gerhardt Attard, Nick Turner, Delila Gasi Tandefelt, Udai Banerji, Timothy A. Yap, Michael Ong, Joaquin Mateo, David Lorente, Roberta Ferraldeschi, Isaac Garcia-Murillas, Christophe Leux, Alan Smith, Daniel Nava-Rodrigues, Ines Figueiredo, Susana Miranda, Ruth Riisnaes, Nina Tunariu, Raquel Perez-Lopez, Desam Roda, Jane Goodall, Suzanne Carreira, Jean Sebastien Frenel
Supplementary Data 6: Monitoring of somatic genomic alterations in plasma during targeted therapy. Allele frequencies (AF) of identified mutations are represented on the left Y-axis while the sum of the target lesions on the CT scan, are represented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9583de46c61b45a6dfc139a846854cf5
https://doi.org/10.1158/1078-0432.22461609
https://doi.org/10.1158/1078-0432.22461609
Autor:
Anthony W. Tolcher, Simone Jueliger, Xiang Yao Su, Aram Oganesian, Harold Keer, Roberta Ferraldeschi, Alain C. Mita, Michael S. Gordon, Kyriakos P. Papadopoulos, Patricia M. LoRusso, Monica M. Mita
Figure S1 shows ASTX660 dose proportionality-power model analyses on AUC0-24 and Cmax by formulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abac9bd21f21bc2c073efe7dffa28f0
https://doi.org/10.1158/1078-0432.22472798
https://doi.org/10.1158/1078-0432.22472798
Autor:
Johann S. de Bono, Arul M. Chinnaiyan, Shahneen Sandhu, Robert Lonigro, Yi-Mi Wu, Lakshmi P. Kunju, Dan R. Robinson, Eric Talevich, Daniel Nava Rodrigues, Mateus Crespo, Ruth Riisnaes, Ines Figueiredo, Susana Miranda, Roberta Ferraldeschi, Gunther Boysen, Maryou Lambros, Claudia Bertan, Suzanne Carreira, Joaquin Mateo, Wei Yuan, George Seed
Plotting a) the median spread of coverage per-gene, from the pooled reference data and b) the per-gene standard deviations for duplicated samples shows that some genes are less reliable than others.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365922b54fe6027f24956a51d0a12d63
https://doi.org/10.1158/1078-0432.22462953.v1
https://doi.org/10.1158/1078-0432.22462953.v1
Autor:
Johann S. de Bono, Gerhardt Attard, Nick Turner, Delila Gasi Tandefelt, Udai Banerji, Timothy A. Yap, Michael Ong, Joaquin Mateo, David Lorente, Roberta Ferraldeschi, Isaac Garcia-Murillas, Christophe Leux, Alan Smith, Daniel Nava-Rodrigues, Ines Figueiredo, Susana Miranda, Ruth Riisnaes, Nina Tunariu, Raquel Perez-Lopez, Desam Roda, Jane Goodall, Suzanne Carreira, Jean Sebastien Frenel
Supplementary Data 1: Primers and probes for ddPCR assay Supplementary Data 2: Consort Diagram Supplementary Data 3: List of drugs Supplementary Data 4: Cross validation of PGM sequencing assay with ddPCR Supplementary Data 5: To test intra-run assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfb6725909481b5f21ca21a1ff79d20
https://doi.org/10.1158/1078-0432.22461606.v1
https://doi.org/10.1158/1078-0432.22461606.v1