Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Roberta Felici"'
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76938 (2013)
Among the enzymes involved in NAD homeostasis, nicotinamide mononucleotide adenylyltransferases (NMNAT1-3) are central to intracellular NAD formation. Although NMNAT3 is postulated to be a mitochondrial enzyme contributing to NAD-dependent organelle
Externí odkaz:
https://doaj.org/article/852bd27d25d14fc1b39587cad7799c56
Publikováno v:
PLoS ONE, Vol 8, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/df1753f3912b4294b8731d5c49b5a94c
Autor:
Sara Pratesi, Roberta Felici, Andrea Lapucci, Francesca Luceri, Daniele Guasti, Leonardo Cavone, Francesco De Cesaris, Daniela Buonvicino, Alberto Chiarugi, Mirko Muzzi
Publikováno v:
Neuropharmacology. 117:74-84
Mitochondrial encephalopathies are fatal, infantile neurodegenerative disorders caused by a deficit of mitochondrial functioning, for which there is urgent need to identify efficacious pharmacological treatments. Recent evidence shows that rapamycin
Autor:
Alberto Chiarugi, Leonardo Cavone, Giuseppe Antonio Ranieri, Roberta Felici, Andrea Lapucci, Sergio Valente, Clemens Zwergel, Antonello Mai, Mirko Muzzi, Daniela Buonvicino, Riccardo Caramelli, Camilla Bernardini, Lorena Di Pietro
Emerging evidence indicates that transcriptome alterations due to epigenetic deregulation concur to ALS pathogenesis. Accordingly, pan-histone deacetylase (HDAC) inhibitors delay ALS development in mice, but these compounds failed when tested in ALS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7d98b6b463882549f4ee86dcadf32f
http://hdl.handle.net/10807/170715
http://hdl.handle.net/10807/170715
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice
Autor:
Andrea Lapucci, Roberta Felici, Elisabetta Gerace, Daniela Buonvicino, Leonardo Cavone, Sergio Valente, Antonello Mai, Clemens Zwergel, Alberto Chiarugi
Publikováno v:
Neuroscience letters. 656
Transcriptional deregulation emerges as a key pathogenetic mechanism in ALS pathogenesis, and non-class-specific histone deacetylase (HDACs) inhibitors proved of therapeutic efficacy in preclinical models of ALS. When tested in patients, however, the
Autor:
Elisa Landucci, F. Moroni, Domenico E. Pellegrini-Giampietro, Francesco Resta, Elisabetta Gerace, Tommaso Mello, Guido Mannaioni, Alessio Masi, Roberta Felici
Publikováno v:
Neurobiology of Disease, Vol 70, Iss, Pp 43-52 (2014)
An excessive activation of poly(ADP-ribose) polymerases (PARPs) may trigger a form of neuronal death similar to that occurring in neurodegenerative disorders. To investigate this process, we exposed organotypic hippocampal slices to N-methyl-N'-nitro
Autor:
Rossella Fucci, Andrea Morandi, Daniele Guasti, Daniele Bani, Massimo Mannelli, Valentino Giachè, Alberto Chiarugi, Elena Rapizzi, Tonino Ercolino, Roberta Felici, Elisa Giannoni, Benedetta Zampetti
Publikováno v:
Hormones and Cancer. 5:174-184
Paragangliomas (PGLs) are rare neuroendocrine tumours. About 30-40 % of these tumours are mutated in one of the different susceptibility genes, including those encoding the different subunits of the succinate dehydrogenase, a complex involved both in
Autor:
Maria Pittelli, Leonardo Cavone, Anna Maria Pugliese, Roberta Felici, Alessio Masi, Elisabetta Coppi, Francesco Blasi, Chiara Traini, Flavio Moroni, Mirko Muzzi, Alberto Chiarugi
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 33:183-190
Therapeutic hypothermia is of relevance to treatment of increased body temperature and brain injury, but drugs inducing selective, rapid, and safe cooling in humans are not available. Here, we show that injections of adenosine 5′-monophosphate (AMP
Autor:
Vanessa Pitozzi, Giovanni Romano, Elisabetta Bigagli, Maria Pittelli, Roberta Felici, Flavio Moroni, Alberto Chiarugi, Lisa Giovannelli, Francesca Cialdai
Publikováno v:
Molecular Pharmacology. 80:1136-1146
During the last several years, evidence that various enzymes hydrolyze NAD into bioactive products prompted scientists to revisit or design strategies able to increase intracellular availability of the dinucleotide. However, plasma membrane permeabil
Autor:
Maria Pittelli, Elena Rapizzi, Flavio Moroni, Alberto Chiarugi, Andrea Lapucci, Roberta Felici
Publikováno v:
Molecular Pharmacology. 79:932-940
Poly(ADP-ribose) polymerase-1 (PARP-1) is a NAD-consuming enzyme with an emerging key role in epigenetic regulation of gene transcription. Although PARP-1 expression is characteristically restricted to the nucleus, a few studies report the mitochondr