Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Roberta Faccio"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Excessive macrophage activation and production of pro-inflammatory cytokines are hallmarks of the Cytokine Storm Syndrome (CSS), a lethal condition triggered by sepsis, autoimmune disorders, and cancer immunotherapies. While depletion of macrophages
Externí odkaz:
https://doaj.org/article/0a541ea526c4412cbc955ded6b5469db
Autor:
Subhashis Pal, Daniel S. Perrien, Tetsuya Yumoto, Roberta Faccio, M. Neale Weitzmann, Roberto Pacifici
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100540- (2024)
Externí odkaz:
https://doaj.org/article/7f5a000edf124d0598b1213347b637e1
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100582- (2024)
Externí odkaz:
https://doaj.org/article/65220d20b2154151a92aeea2fb1106ef
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100580- (2024)
Externí odkaz:
https://doaj.org/article/846ff49eca7740a39d53ddb2c4538cad
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100577- (2024)
Externí odkaz:
https://doaj.org/article/cfc7a32a93e448c3a94d78009a1fae4d
Autor:
Jennifer L. Davis, Nitin Kumar Pokhrel, Linda Cox, Nidhi Rohatgi, Roberta Faccio, Deborah J. Veis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract NF-κB has been reported to both promote and inhibit bone formation. To explore its role in osteolineage cells, we conditionally deleted IKKα, an upstream kinase required for non-canonical NF-κB activation, using Osterix (Osx)-Cre. Surpris
Externí odkaz:
https://doaj.org/article/8867845baa704d7090249e91d1881a45
The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone
Autor:
Subhashis Pal, Daniel S. Perrien, Tetsuya Yumoto, Roberta Faccio, Andreea Stoica, Jonathan Adams, Craig M. Coopersmith, Rheinallt M. Jones, M. Neale Weitzmann, Roberto Pacifici
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
Bone metastases are frequent complications of malignant melanoma leading to reduced quality of life and significant morbidity. Regulation of immune cells by the gut microbiome influences cancer progression, but the role of the microbiome in tumor gro
Externí odkaz:
https://doaj.org/article/0ac1f9b7c55d481081666201ef90533a
Autor:
Jennifer L Davis, Roman Thaler, Linda Cox, Biancamaria Ricci, Heather M Zannit, Fei Wan, Roberta Faccio, Amel Dudakovic, Andre J van Wijnen, Deborah J Veis
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254426 (2021)
Aberrant NF-κB signaling fuels tumor growth in multiple human cancer types including both hematologic and solid malignancies. Chronic elevated alternative NF-κB signaling can be modeled in transgenic mice upon activation of a conditional NF-κB-ind
Externí odkaz:
https://doaj.org/article/d8db811e861d4f609a79355033e728a4
Autor:
Biancamaria Ricci, Eric Tycksen, Hamza Celik, Jad I Belle, Francesca Fontana, Roberto Civitelli, Roberta Faccio
Publikováno v:
eLife, Vol 9 (2020)
Cancer-associated fibroblasts (CAFs) are a heterogeneous population of mesenchymal cells supporting tumor progression, whose origin remains to be fully elucidated. Osterix (Osx) is a marker of osteogenic differentiation, expressed in skeletal progeni
Externí odkaz:
https://doaj.org/article/b235142a091540bfb386adbea458e890
Autor:
Melissa A. Meyer, John M. Baer, Brett L. Knolhoff, Timothy M. Nywening, Roheena Z. Panni, Xinming Su, Katherine N. Weilbaecher, William G. Hawkins, Cynthia Ma, Ryan C. Fields, David C. Linehan, Grant A. Challen, Roberta Faccio, Rebecca L. Aft, David G. DeNardo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Tumors escape the immune system through many mechanisms. Here the authors show that certain tumors inhibit anti-tumor immunity by stopping the production of conventional dendritic cells (cDCs) in the bone marrow, therefore depleting the pool of cDCs
Externí odkaz:
https://doaj.org/article/8ebabe15d49943d1834201842048ea26