Editorial: Peptidases as a therapeutic target in anti-cancer management

Autor: Ana Mitrović, Roberta E. Burden, Adaleta Softič, Nežka Kavčič

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Externí odkaz: https://doaj.org/article/08aeb179732045bab1faeeaaad1840b3

Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer

Autor: Naphannop Sereesongsaeng, Sara H. McDowell, James F. Burrows, Christopher J. Scott, Roberta E. Burden

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)

Abstract Background Lysosomal cysteine protease cathepsin V has previously been shown to exhibit elevated expression in breast cancer tissue and be associated with distant metastasis. Research has also identified that cathepsin V expression is elevat

Externí odkaz: https://doaj.org/article/f0f6b2ce326a44db8cf62786ac66b46c

Trafficking of Full-Length and N-Terminally Truncated Cathepsin B in Human Colorectal Carcinoma Cells

Autor: Tripti Tamhane, Robin W. Njenga, Roberta E. Burden, Heiko Büth, Gunhild M. Maelandsmo, Mads H. Haugen, Christopher J. Scott, Klaudia Brix

Publikováno v: Applied Sciences, Vol 11, Iss 24, p 11936 (2021)

Cathepsin B is an endo-lysosomal cysteine protease. However, its increased expression and altered localization to the extracellular space, to mitochondria, or to the nucleus has been linked to tumor progression. In the present study, we show enhanced

Externí odkaz: https://doaj.org/article/36dd7bfb93564673ba3364d600283128

USP17 is required for peripheral trafficking of lysosomes

Autor: Jia Lin, Aidan P McCann, Naphannop Sereesongsaeng, Jonathan M Burden, Alhareth A Alsa’d, Roberta E Burden, Ileana Micu, Richard Williams, Sandra Van Schaeybroeck, Emma Evergren, Paul Mullan, Jeremy C Simpson, Christopher J Scott, James F Burrows

Publikováno v: Lin, J, McCann, A, Sereesongsaeng, N, Burden, J, Alsa'd, A A M, Burden, R, Micu, I, Williams, R, Van Schaeybroeck, S, Evergren, E, Mullan, P, Scott, C & Burrows, J 2022, ' USP17 is required for peripheral trafficking of lysosomes ', EMBO Reports . https://doi.org/10.15252/embr.202051932

Expression of the deubiquitinase USP17 is induced by multiple stimuli, including cytokines (IL-4/6), chemokines (IL-8, SDF1), and growth factors (EGF), and several studies indicate it is required for cell proliferation and migration. However, the mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1620489c446b5d366be14ac3cfc91d68
https://doi.org/10.15252/embr.202051932

Procathepsin V is secreted in a TSH regulated manner from human thyroid epithelial cells and is accessible to an activity-based probe

Autor: Sebastian Springer, Klaudia Brix, Matthew Bogyo, Dagmar Führer, Ekkehard Weber, Maren Rehders, Zeynep Hein, Alaa Al-Hashimi, Naphannop Sereesongsaeng, Christopher J. Scott, Roberta E. Burden, Vaishnavi Venugopalan

Publikováno v: Al-Hashimi, A, Venugopalan, V, Rehders, M, Sereesongsaeng, N, Hein, Z, Springer, S, Weber, E, Führer, D, Bogyo, M S, Scott, C J, Burden, R E & Brix, K 2020, ' Procathepsin V is secreted in a TSH regulated manner from human thyroid epithelial cells and is accessible to an activity-based probe ', International Journal of Molecular Sciences, vol. 21, no. 23, 9140 . https://doi.org/10.3390/ijms21239140
International Journal of Molecular Sciences
Volume 21
Issue 23
International Journal of Molecular Sciences, Vol 21, Iss 9140, p 9140 (2020)

The significance of cysteine cathepsins for the liberation of thyroid hormones from the precursor thyroglobulin was previously shown by in vivo and in vitro studies. Cathepsin L is most important for thyroglobulin processing in mice. The present stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab146593ba8d70e597d8be483ff7976
https://pure.qub.ac.uk/en/publications/231eee71-80bc-4361-aac9-8c8dd36b44fa