Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Roberta E Burden"'
Autor:
Claire Ward, Diana Kuehn, Roberta E Burden, Julie A Gormley, Thomas J Jaquin, Mihaela Gazdoiu, Donna Small, Roy Bicknell, James A Johnston, Christopher J Scott, Shane A Olwill
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12489 (2010)
BACKGROUND: Angiogenesis is a key hallmark of tumourigenesis and its inhibition is a proven strategy for the development of novel anti-cancer therapeutics. An important aspect of early angiogenesis is the co-ordinated migration and invasion of endoth
Externí odkaz:
https://doaj.org/article/3e20d26756f14f4193cfcc32518e6ad2
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/08aeb179732045bab1faeeaaad1840b3
Autor:
Naphannop Sereesongsaeng, James F. Burrows, Christopher J. Scott, Klaudia Brix, Roberta E. Burden
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: We previously identified that Cathepsin V (CTSV) expression is associated with poor prognosis in ER+ breast cancer, particularly within the Luminal A subtype. Examination of the molecular role of the protease within Luminal A tumours, r
Externí odkaz:
https://doaj.org/article/6022cd10f8d44227a9e850c59270425d
Autor:
Naphannop Sereesongsaeng, Sara H. McDowell, James F. Burrows, Christopher J. Scott, Roberta E. Burden
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Abstract Background Lysosomal cysteine protease cathepsin V has previously been shown to exhibit elevated expression in breast cancer tissue and be associated with distant metastasis. Research has also identified that cathepsin V expression is elevat
Externí odkaz:
https://doaj.org/article/f0f6b2ce326a44db8cf62786ac66b46c
Autor:
Aidan P. McCann, Peter Smyth, Francesco Cogo, William J. McDaid, Lai Jiang, Jia Lin, Emma Evergren, Roberta E. Burden, Sandra Van Schaeybroeck, Christopher J. Scott, James F. Burrows
Publikováno v:
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Background The deubiquitinase USP17 is overexpressed in NSCLC and has been shown to be required for the growth and motility of EGFR wild-type (WT) NSCLC cells. USP17 is also required for clathrin-mediated endocytosis of EGFR. Here, we examin
Externí odkaz:
https://doaj.org/article/389459c8bc77420cac6802a897ba1482
Autor:
Tripti Tamhane, Robin W. Njenga, Roberta E. Burden, Heiko Büth, Gunhild M. Maelandsmo, Mads H. Haugen, Christopher J. Scott, Klaudia Brix
Publikováno v:
Applied Sciences, Vol 11, Iss 24, p 11936 (2021)
Cathepsin B is an endo-lysosomal cysteine protease. However, its increased expression and altered localization to the extracellular space, to mitochondria, or to the nucleus has been linked to tumor progression. In the present study, we show enhanced
Externí odkaz:
https://doaj.org/article/36dd7bfb93564673ba3364d600283128
Autor:
Alaa Al-Hashimi, Vaishnavi Venugopalan, Maren Rehders, Naphannop Sereesongsaeng, Zeynep Hein, Sebastian Springer, Ekkehard Weber, Dagmar Führer, Matthew S. Bogyo, Christopher J. Scott, Roberta E. Burden, Klaudia Brix
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9140 (2020)
The significance of cysteine cathepsins for the liberation of thyroid hormones from the precursor thyroglobulin was previously shown by in vivo and in vitro studies. Cathepsin L is most important for thyroglobulin processing in mice. The present stud
Externí odkaz:
https://doaj.org/article/4f41198861294dbc80c6e83b3477bace
Autor:
James F Burrows, Naphannop Sereesongsaeng, Roberta E. Burden, Sara H. McDowell, Christopher J. Scott
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Breast Cancer Research : BCR
Sereesongsaeng, N, McDowell, S H, Burrows, J F, Scott, C J & Burden, R E 2020, ' Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer ', Breast Cancer Research, vol. 22, no. 1, pp. 139 . https://doi.org/10.1186/s13058-020-01376-6
Breast Cancer Research : BCR
Sereesongsaeng, N, McDowell, S H, Burrows, J F, Scott, C J & Burden, R E 2020, ' Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer ', Breast Cancer Research, vol. 22, no. 1, pp. 139 . https://doi.org/10.1186/s13058-020-01376-6
Background Lysosomal cysteine protease cathepsin V has previously been shown to exhibit elevated expression in breast cancer tissue and be associated with distant metastasis. Research has also identified that cathepsin V expression is elevated in tum
Autor:
Jia Lin, Aidan P McCann, Naphannop Sereesongsaeng, Jonathan M Burden, Alhareth A Alsa’d, Roberta E Burden, Ileana Micu, Richard Williams, Sandra Van Schaeybroeck, Emma Evergren, Paul Mullan, Jeremy C Simpson, Christopher J Scott, James F Burrows
Publikováno v:
Lin, J, McCann, A, Sereesongsaeng, N, Burden, J, Alsa'd, A A M, Burden, R, Micu, I, Williams, R, Van Schaeybroeck, S, Evergren, E, Mullan, P, Scott, C & Burrows, J 2022, ' USP17 is required for peripheral trafficking of lysosomes ', EMBO Reports . https://doi.org/10.15252/embr.202051932
Expression of the deubiquitinase USP17 is induced by multiple stimuli, including cytokines (IL-4/6), chemokines (IL-8, SDF1), and growth factors (EGF), and several studies indicate it is required for cell proliferation and migration. However, the mec
Autor:
Vaishnavi Venugopalan, Roberta E. Burden, Ekkehard Weber, Klaudia Brix, Zeynep Hein, Sebastian Springer, Dagmar Führer, Alexandra M. Pinzaru, Alaa Al-Hashimi, Christopher J. Scott, Sofia Tedelind, Naphannop Sereesongsaeng
Publikováno v:
Al-Hashimi, A, Venugopalan, V, Sereesongsaeng, N, Tedelind, S, Pinzaru, A M, Hein, Z, Springer, S, Weber, E, Führer, D, Scott, C J, Burden, R E & Brix, K 2020, ' Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells ', Biochimica et Biophysica Acta-Molecular Cell Research, vol. 1867, no. 12, 118846 . https://doi.org/10.1016/j.bbamcr.2020.118846
Altered expression and/or localization of cysteine cathepsins is believed to involve in thyroid diseases including cancer. Here, we examined the localization of cathepsins B and V in human thyroid tissue sections of different pathological conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29eaa04364a841197516ab68e672b361
https://pure.qub.ac.uk/en/publications/3b2bc61c-db81-4ad1-9ad0-05a49eae32e2
https://pure.qub.ac.uk/en/publications/3b2bc61c-db81-4ad1-9ad0-05a49eae32e2