Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Roberta D. Brinton"'
Publikováno v:
Neurobiology of Stress, Vol 21, Iss , Pp 100502- (2022)
Chronic stress has been proposed as a driver of altered brain structure and function, including the pathogenesis of neurodegenerative diseases and a driver of disease progression. A key outcome of stress in the brain is structural remodeling of neura
Externí odkaz:
https://doaj.org/article/e9599b8a21e54e218fe53b446ee5e4e9
Autor:
Adam C. Raikes, Gerson D. Hernandez, Veronica A. Mullins, Yiwei Wang, Claudia Lopez, William D. S. Killgore, Floyd H. Chilton, Roberta D. Brinton
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
ContextRepetitive sub-concussive head impacts (RSHIs) are common in American football and result in changes to the microstructural integrity of white matter. Both docosahexaenoic acid (DHA) and eicosapentaoic acid (EPA) supplementation exerted neurop
Externí odkaz:
https://doaj.org/article/ded2265f8cf041fab02a5039876598d0
Autor:
Matthias Arnold, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak MahmoudianDehkordi, Gregory Louie, M. Arthur Moseley, J. Will Thompson, Lisa St John-Williams, Jessica D. Tenenbaum, Colette Blach, Rui Chang, Roberta D. Brinton, Rebecca Baillie, Xianlin Han, John Q. Trojanowski, Leslie M. Shaw, Ralph Martins, Michael W. Weiner, Eugenia Trushina, Jon B. Toledo, Peter J. Meikle, David A. Bennett, Jan Krumsiek, P. Murali Doraiswamy, Andrew J. Saykin, Rima Kaddurah-Daouk, Gabi Kastenmüller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Sex and the APOE ε4 genotype are important risk factors for late-onset Alzheimer’s disease. In the current study, the authors investigate how sex and APOE ε4 genotype modify the association between Alzheimer’s disease biomarkers and metabolites
Externí odkaz:
https://doaj.org/article/4622f4afa16f4c509372906b7b40a13c
Autor:
Adam C. Raikes, Gerson D. Hernandez, Dawn C. Matthews, Ana S. Lukic, Meng Law, Yonggang Shi, Lon S. Schneider, Roberta D. Brinton
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Allopregnanolone (ALLO), an endogenous neurosteroid, promoted neurogenesis and oligogenesis and restored cognitive function in animal models of Alzheimer's disease (AD). Based on these discovery research findings, we conducted a
Externí odkaz:
https://doaj.org/article/b053f6f6db734490a34e7282889c5275
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101829- (2020)
Summary: Aging and endocrine transition states can significantly impact inflammation across organ systems. Neuroinflammation is well documented in Alzheimer disease (AD). Herein, we investigated neuroinflammation that emerges during mid-life aging, c
Externí odkaz:
https://doaj.org/article/aedff3e8737c47e9b21f52d74cee8ec1
Autor:
Gerson D. Hernandez, Christine M. Solinsky, Wendy J. Mack, Naoko Kono, Kathleen E. Rodgers, Chun‐Yi Wu, Ana R. Mollo, Claudia M. Lopez, Sonia Pawluczyk, Gerhard Bauer, Dawn Matthews, Yonggang Shi, Meng Law, Michael A. Rogawski, Lon S. Schneider, Roberta D. Brinton
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Allopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well‐established preclinical safety efficacy m
Externí odkaz:
https://doaj.org/article/5850674a3da74dfebad3206ffcd3f5dc
Autor:
Aarti Mishra, Roberta D. Brinton
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Neuro-inflammatory processes that contribute to development of Alzheimer’s are evident early in the latent prodromal phase and worsen during the course of the disease. Despite substantial mechanistic and clinical evidence of inflammation, therapeut
Externí odkaz:
https://doaj.org/article/7ddf5a00087641b2a7c7d3899d8ebc89
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Externí odkaz:
https://doaj.org/article/44c6a769ba0a49d7a4a4c52ff6c5c507
Autor:
Yashi Mi, Guoyuan Qi, Francesca Vitali, Yuan Shang, Adam C. Raikes, Tian Wang, Yan Jin, Roberta D. Brinton, Haiwei Gu, Fei Yin
Publikováno v:
Nature Metabolism. 5:445-465
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ee30279b8ed41823e3d1eb26041237
https://doi.org/10.1038/s42255-023-00756-4
https://doi.org/10.1038/s42255-023-00756-4
Autor:
Rui, Chang, Eugenia, Trushina, Kuixi, Zhu, Syed Shujaat Ali, Zaidi, Branden M, Lau, Alexandra, Kueider-Paisley, Sara, Moein, Qianying, He, Melissa L, Alamprese, Barbora, Vagnerova, Andrew, Tang, Ramachandran, Vijayan, Yanyun, Liu, Andrew J, Saykin, Roberta D, Brinton, Rima, Kaddurah-Daouk
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES.
Late-onset Alzheimer's disease (LOAD) is a complex neurodegenerative disease characterized by multiple progressive stages, glucose metabolic dysregulation, Alzheimer's disease (AD) pathology, and inexorable cognitive decline. Discovery of metabolic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35a2f97c41559019ad2960f2b4f76bd
https://pubmed.ncbi.nlm.nih.gov/35481667
https://pubmed.ncbi.nlm.nih.gov/35481667