Výsledky vyhledávání - "Roberta Colladel"

Akademický článek

Multimerin-2 orchestrates the cross-talk between endothelial cells and pericytes: A mechanism to maintain vascular stability

Autor: Albina Fejza, Evelina Poletto, Greta Carobolante, Lucrezia Camicia, Eva Andreuzzi, Alessandra Capuano, Eliana Pivetta, Rosanna Pellicani, Roberta Colladel, Stefano Marastoni, Roberto Doliana, Renato V. Iozzo, Paola Spessotto, Maurizio Mongiat

Publikováno v: Matrix Biology Plus, Vol 11, Iss , Pp 100068- (2021)

Tumor angiogenesis is vital for the growth and development of various solid cancers and as such is a valid and promising therapeutic target. Unfortunately, the use of the currently available anti-angiogenic drugs increases the progression-free surviv

Externí odkaz: https://doaj.org/article/45f47ab227db4cefb1390e3c86dc01b4

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Multimerin-2 maintains vascular stability and permeability

Autor: Giorgio M. Bressan, Alfonso Colombatti, Giulia Tarticchio, Eva Andreuzzi, Paola Braghetta, Paolo Bonaldo, Patrizia Sabatelli, Alice Paulitti, Rosanna Pellicani, Dario Bizzotto, Renato V. Iozzo, E. Poletto, Francesco Bucciotti, Maurizio Mongiat, Roberta Colladel, Roberto Doliana

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology. 87

Multimerin-2 is an extracellular matrix glycoprotein and member of the elastin microfibril interface-located (EMILIN) family of proteins. Multimerin-2 is deposited along blood vessels and we previously demonstrated that it regulates the VEGFA/VEGFR2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b3de4613c5ca3a346fe09a36d4f9b0
https://pubmed.ncbi.nlm.nih.gov/31422156

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MULTIMERIN2 binds VEGF-A primarily via the carbohydrate chains exerting an angiostatic function and impairing tumor growth

Autor: F. Todaro, Eva Andreuzzi, Alfonso Colombatti, Giulia Tarticchio, Roberta Colladel, Alice Paulitti, Maurizio Mongiat, Rosanna Pellicani

Publikováno v: Oncotarget

Angiogenesis is a key process occurring under both physiological and pathological conditions and is a hallmark of cancer. We have recently demonstrated that the extracellular matrix (ECM) molecule MULTIMERIN2 exerts an angiostatic function through th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e030679e218f871d7c22c9b63c360d3
http://europepmc.org/articles/PMC4811514

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The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis

Autor: Eva Andreuzzi, Rosanna Pellicani, Benedetta Bussolati, Paola Spessotto, Alessia Brossa, Paolo De Paoli, Maurizio Mongiat, Roberta Colladel, Renato Cannizzaro, Alfonso Colombatti, Giulia Tarticchio, Renato V. Iozzo, Vincenzo Canzonieri

Angiogenesis is a crucial process occurring under physiological and pathological conditions, including cancer. The development of blood vessels is tightly regulated by a plethora of cytokines, endothelial cell (EC) receptors and extracellular matrix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffb80d6581d187ce29b573354a46208
http://hdl.handle.net/11368/2968898

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EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration

Autor: Eva Andreuzzi, Alvise Schiavinato, Roberta Colladel, F. Todaro, Rosanna Pellicani, Alice Paulitti, Maurizio Mongiat, Paolo Bonaldo, Alfonso Colombatti, Stefano Marastoni

Publikováno v: The Journal of Pathology. 232:391-404

EMILIN2 is an extracellular matrix (ECM) protein that exerts contradictory effects within the tumour microenvironment: it induces apoptosis in a number of tumour cells, but it also enhances tumour neo-angiogenesis. In this study, we describe a new me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a34fc975c95eeb55a7950c4bc38f9877
https://doi.org/10.1002/path.4316

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MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway

Autor: Giovanni Ligresti, Stefano Marastoni, Eva Andreuzzi, Maurizio Mongiat, Alfonso Colombatti, E. Lorenzon, F. Todaro, Roberta Colladel, Monica Schiappacassi

Publikováno v: Oncogene. 31:3136-3147

MULTIMERIN2 (MMRN2), also known as Endoglyx-1, is an extracellular matrix glycoprotein whose function has so far remained elusive. Given its specific localization in tight association with the endothelium we hypothesized that this protein could modul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786fb22815229b270ea479bd688a628a
https://doi.org/10.1038/onc.2011.487

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Therapeutical Cues from the Tumor Microenvironment

Autor: Maurizio Mongiat, F. Todaro, Alessandra Silvestri, Eva Andreuzzi, Alice Paulitti, Alfonso Colombatti, Stefano Marastoni, Roberta Colladel

Publikováno v: Advances in Cancer Therapy

The tumor can be considered a complex organ where transformed cells characterized by high genomic instability and altered gene expression are interconnected and communicate with the surrounding microenvironment. The microenvironment (Fig. 1) is compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7add30a6df0d723351028f0b6349504b
https://doi.org/10.5772/24796

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