Data from Acquisition of Chemoresistance and EMT Phenotype Is Linked with Activation of the Endothelin A Receptor Pathway in Ovarian Carcinoma Cells

Autor: Anna Bagnato, Pier Giorgio Natali, Gabriella Ferrandina, Alessandro Lucidi, Maria Rita Nicotra, Valeriana Di Castro, Francesca Spinella, Roberta Cianfrocca, Laura Rosanò

Purpose: Emerging evidence suggests molecular and phenotypic association between chemoresistance and epithelial–mesenchymal transition (EMT) in cancer. Endothelin-1 (ET-1)/endothelin A receptor (ETAR) axis is implicated in the pathobiology of epith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc87d16df51b43923bad360de729679
https://doi.org/10.1158/1078-0432.c.6519524.v1

Supplementary Figure S2 from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy

Autor: Anna Bagnato, Pier Giorgio Natali, Gabriella Ferrandina, Elisa Semprucci, Valentina Caprara, Valeriana Di Castro, Francesca Spinella, Piera Tocci, Roberta Cianfrocca, Laura Rosanò

Supplementary Figure S2. Analysis of β-arr1 or β-catenin knockdown and effects of ETAR-driven β-arr1/β-catenin nuclear complexes on ET-1 expression.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771ce0f7541c2db6422980dc308ecc1b
https://doi.org/10.1158/0008-5472.22401399.v1

Supporting Materials and Methods; Supporting References from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy

Autor: Anna Bagnato, Pier Giorgio Natali, Gabriella Ferrandina, Elisa Semprucci, Valentina Caprara, Valeriana Di Castro, Francesca Spinella, Piera Tocci, Roberta Cianfrocca, Laura Rosanò

Supporting Materials and Methods; Supporting References

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a53e6c1e61f2b35903d2d31a25737ec
https://doi.org/10.1158/0008-5472.22401375

β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer

Autor: Anna Bagnato, Giovanni Scambia, Gabriele Bucci, Silvia Bonfiglio, Giovanni Tonon, Valeriana Di Castro, Enrico Vizza, Roberta Cianfrocca, Piera Tocci, Laura Rosanò, Sara Donzelli, Giovanni Blandino, Gabriella Ferrandina, Andrea Sacconi

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature communications 10 (2019). doi:10.1038/s41467-019-11045-8
info:cnr-pdr/source/autori:Tocci, Piera; Cianfrocca, Roberta; Di Castro, Valeriana; Rosano, Laura; Sacconi, Andrea; Donzelli, Sara; Bonfiglio, Silvia; Bucci, Gabriele; Vizza, Enrico; Ferrandina, Gabriella; Scambia, Giovanni; Tonon, Giovanni; Blandino, Giovanni; Bagnato, Anna/titolo:beta-arrestin1%2FYAP%2Fmutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer/doi:10.1038%2Fs41467-019-11045-8/rivista:Nature communications/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Nature Communications

The limited clinical response observed in high-grade serous ovarian cancer (HG-SOC) with high frequency of TP53 mutations (mutp53) might be related to mutp53-driven oncogenic pathway network. Here we show that β-arrestin1 (β-arr1), interacts with Y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1dd497bb6b5008e627574816810ef3
https://doaj.org/article/924a8b602fdb4153a08a0593bfc1aea7

Targeting endothelin 1 receptor-miR-200b/c-ZEB1 circuitry blunts metastatic progression in ovarian cancer

Autor: Giovanni Blandino, Roberta Cianfrocca, Andrea Sacconi, Anna Bagnato, Piera Tocci, Laura Rosanò, Rosanna Sestito

Publikováno v: Communications biology (2020). doi:10.1038/s42003-020-01404-3
info:cnr-pdr/source/autori:Rosanna Sestito, Roberta Cianfrocca, Piera Tocci, Laura Rosanò, Andrea Sacconi, Giovanni Blandino & Anna Bagnato/titolo:Targeting endothelin 1 receptor-miR-200b%2Fc-ZEB1 circuitry blunts metastatic progression in ovarian cancer/doi:10.1038%2Fs42003-020-01404-3/rivista:Communications biology/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)

Identification of regulatory mechanisms underlying the poor prognosis of ovarian cancer is necessary for diagnostic and therapeutic implications. Here we show that endothelin A receptor (ETAR) and ZEB1 expression is upregulated in mesenchymal ovarian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1467b3bdef18f6f0df368804e0d51f
https://publications.cnr.it/doc/436045