Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Roberta A. Thomas"'
Autor:
Marjory B Brooks, James R Turk, Abraham Guerrero, Padma K Narayanan, John P Nolan, Elizabeth G Besteman, Dennis W Wilson, Roberta A Thomas, Cindy E Fishman, Karol L Thompson, Heidrun Ellinger-Ziegelbauer, Jennifer B Pierson, April Paulman, Alan Y Chiang, Albert E Schultze
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169976 (2017)
Systemic inflammation co-activates coagulation, which unchecked culminates in a lethal syndrome of multi-organ microvascular thrombosis known as disseminated intravascular coagulation (DIC). We studied an endotoxin-induced inflammatory state in rats
Externí odkaz:
https://doaj.org/article/d1a2148f4656495f9cebe693e28738c6
Autor:
Félix Goulet, Nacera Mellal, Liangfu Chen, Mark S Watkins, Elaine Debien, David F. Adams, Roberta A. Thomas, Wei Shi, Kendall S. Frazier, Erding Hu, Luc Durette, Josée Laliberté
Publikováno v:
Toxicologic Pathology. 48:362-378
Daprodustat (GSK1278863) is a hypoxia-inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor in development for treatment of anemia of chronic kidney disease. Daprodustat’s biological activity simulates components of the natural response to hypo
Autor:
John P. Nolan, Jennifer B. Pierson, Marjory B. Brooks, James R. Turk, Cindy E. Fishman, Dennis W Wilson, Heidrun Ellinger-Ziegelbauer, Albert E. Schultze, April Paulman, Karol L. Thompson, Padma K. Narayanan, Abraham Guerrero, Elizabeth G. Besteman, Roberta A. Thomas, Alan Y. Chiang
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169976 (2017)
PLoS ONE
PLoS ONE
Systemic inflammation co-activates coagulation, which unchecked culminates in a lethal syndrome of multi-organ microvascular thrombosis known as disseminated intravascular coagulation (DIC). We studied an endotoxin-induced inflammatory state in rats
Autor:
Tanja S. Zabka, Bradley E. Enerson, Michael P. Lawton, Raymond J. Gonzalez, Marshall S. Scicchitano, Peter Hoffmann, Deidre A. Dalmas, Mark Cameron, James L. Weaver, Nicholas M.P. King, Holly W. Smith, Igor Mikaelian, Silvia Guionaud, Roberta A. Thomas
Publikováno v:
Toxicologic Pathology. 42:635-657
Better biomarkers are needed to identify, characterize, and/or monitor drug-induced vascular injury (DIVI) in nonclinical species and patients. The Predictive Safety Testing Consortium (PSTC), a precompetitive collaboration of pharmaceutical companie
Autor:
Kendall S. Frazier, Heath C. Thomas, Rosanna C. Mirabile, Nancy T. Chau, Roberta A. Thomas, Marshall S. Scicchitano
Publikováno v:
Toxicology and Applied Pharmacology. 262:310-320
Regulatory miRNAs play a role in vascular biology and are involved in biochemical and molecular pathways dysregulated during vascular injury. Collection and integration of functional miRNA data into these pathways can provide insight into pathogenesi
Autor:
Heath C. Thomas, Marshall S. Scicchitano, Kendall S. Frazier, David C. McFarland, Dana C. Pietrzak, Roberta A. Thomas
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 60:263-274
Introduction There are currently few widely accepted noninvasive detection methods for drug-induced vascular damage. Circulating endothelial progenitor cell (EPC) enumeration in humans has recently gained attention as a potential biomarker of vascula
Autor:
Rogely W. Boyce, Roberta A. Thomas, Rosanna C. Mirabile, Scot L. Eustis, Sabine Rehm, Kim S. Smith, Tracy L. Gales
Publikováno v:
Toxicologic Pathology. 35:958-971
Novel vascular lesions were observed in mice given an alpha vbeta 3, alpha vbeta 5 receptor antagonist (SB-273005) for up to 3 months. Vascular smooth muscle cell (VSMC) necrosis was observed in aorta and renal hilar arteries approximately 6 hours af
Autor:
Roberta A. Thomas, Kendall S. Frazier, Stephane Huet, Nicholas J. Laping, Françoise Gellibert, Rogely W. Boyce, Anne-Charlotte DeGouville, James Nold, Rosanna C. Mirabile, Dawn Zimmerman, Marshall S. Scicchitano, Eugene T. Grygielko
Publikováno v:
Toxicologic Pathology. 35:284-295
TGF-|β|, and its type 1 (ALK5) receptor, are critical to the pathogenesis of fibrosis. In toxicologic studies of 4 or more days in 10-week-old Sprague–Dawley rats, using an ALK5 inhibitor (GW788388), expansion of hypertrophic and proliferation zon
Autor:
Deidre A. Dalmas, Leah R. Turner, Roberta A. Thomas, Melissa A. Bertiaux, Shawn Anderson, Rogely W. Boyce, Marshall S. Scicchitano, Rossana Mirable
Publikováno v:
Journal of Histochemistry & Cytochemistry. 54:1229-1237
Microarrays have been used to simultaneously monitor the expression of thousands of genes from biological samples, an approach that can potentially uncover previously unrecognized functions of genes. Microarray analyses can rarely be conducted retros
Autor:
Dawn Zimmerman, Lester W. Schwartz, Rogely W. Boyce, Lisa DeBoer, Deidre A. Dalmas, Marshall S. Scicchitano, Lauren A. Tierney, Roberta A. Thomas
Publikováno v:
Journal of Histotechnology. 26:181-184
Automated nonisotopic In Situ hybridization (ISH) protocols with and without tyramide amplification with a sensitivity capable of detecting relatively low-abundance mRNA using a combination of the Ventana Discovery System® and DAKO Autostainer® hav