Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Roberta A. Mittelstaedt"'
Publikováno v:
BioTechniques, Vol 47, Iss 4, Pp 867-869 (2009)
Quantitative real-time PCR has become a popular method to analyze and quantify changes in the copy number of mitochondrial DNA (mtDNA), and nuclear DNA (nDNA) is often used as an endogenous reference for mtDNA abundance. In our experience, using nDNA
Externí odkaz:
https://doaj.org/article/d503d29c47694cd781bf429156fafb1f
Autor:
Varsha G. Desai, Taewon Lee, Carrie L. Moland, William S. Branham, Roberta A. Mittelstaedt, Sherry M. Lewis, Julian E. A. Leakey, James C. Fuscoe
Publikováno v:
AIDS Research and Treatment, Vol 2012 (2012)
The effects of 12-week exposure to zidovudine (AZT) at 400, 500, and 600 mg/kg/d were examined on expression of 542 mitochondria-related genes and mitochondrial DNA (mtDNA) copy number in the liver of male and female B6C3F1 mice to understand mitocho
Externí odkaz:
https://doaj.org/article/de3287a29a3c45bfb09c952ecd52aa43
Autor:
Xilin Li, Yuan Le, Ji-Eun Seo, Xiaoqing Guo, Yuxi Li, Si Chen, Roberta A. Mittelstaedt, Nyosha Moore, Sharon Guerrero, Audrey Sims, Sruthi T. King, Aisar H. Atrakchi, Timothy J. McGovern, Karen L. Davis-Bruno, David A. Keire, Rosalie K. Elespuru, Robert H. Heflich, Nan Mei
Publikováno v:
Regulatory Toxicology and Pharmacology. 141:105410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d0da53ed2d8091ded46be2e2ff9bb85
https://doi.org/10.1016/j.yrtph.2023.105410
https://doi.org/10.1016/j.yrtph.2023.105410
Autor:
Elizabeth K. Schmidt, Roberta A. Mittelstaedt, Timothy W. Robison, Xuefei Cao, Ying Chen, Wei Sun, Rebecca Wynne, Yiying Wang, Levan Muskhelishvili, Charles C. Valentine, Thomas H. Smith, Lindsey N. Williams, Zachary K Norgaard, Robert H. Heflich, Kelly Davis, Jesse J. Salk, Jeffry Yaplee
Publikováno v:
Environmental and Molecular Mutagenesis
The organotypic human air‐liquid‐interface (ALI) airway tissue model has been used as an in vitro cell culture system for evaluating the toxicity of inhaled substances. ALI airway cultures are highly differentiated, which has made it challenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2149b0742866ddafa9a6c2b7b5751dd5
http://europepmc.org/articles/PMC8251634
http://europepmc.org/articles/PMC8251634
Autor:
Rena G. Lapidus, Timothy W. Robison, Vasily N. Dobrovolsky, Javier R. Revollo, Mason G. Pearce, Roberta A. Mittelstaedt, Azra Dad, Andrea Casildo
Publikováno v:
Environmental and Molecular Mutagenesis. 61:797-806
Procarbazine (PCZ) and N-propyl-N-nitrosourea (PNU) are rodent mutagens and carcinogens. Both induce GPI-anchored marker-deficient mutant-phenotype red blood cells (RBCs) in the flow cytometry-based rat RBC Pig-a assay. In the present study, we trace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039df95c761c4ac2d8c97e82a3a57131
https://doi.org/10.1002/em.22402
https://doi.org/10.1002/em.22402
Publikováno v:
Environmental and molecular mutagenesisREFERENCES. 62(9)
In order to investigate the possibility that treatment age affects the genotoxic response to ethyl methane sulfonate (EMS) exposure, we dosed gpt-delta neonatal mice on postnatal days 1-28 with 5-100 mg/kg/day of EMS and measured micronucleus (MN) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fe3a777d7f568f168a6dec4ccd1284
https://pubmed.ncbi.nlm.nih.gov/34647641
https://pubmed.ncbi.nlm.nih.gov/34647641
Autor:
Raymond Yeager, Seonggi Min, Vasily N. Dobrovolsky, Mason G. Pearce, Mallikarjuna S. Basavarajappa, Hans Rosenfeldt, Hyun-Ki Kang, Yiying Wang, Yunan Tang, Shu-Chieh Hu, Berran Yucesoy, Dong-Jin Yang, Javier R. Revollo, Roberta A. Mittelstaedt, Robert H. Heflich, Azra Dad, Page B. McKinzie
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 837:65-72
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a genotoxic carcinogen found in tobacco and tobacco smoke. Several in vitro and in vivo assays have been used for evaluating the genotoxicity of tobacco smoke and tobacco smoke constituents like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddadec5fe55cb229a62bcfa5647f0baa
https://doi.org/10.1016/j.mrgentox.2018.10.007
https://doi.org/10.1016/j.mrgentox.2018.10.007
Autor:
Steven B Yee, Wei Ding, Mason G. Pearce, Shu-Chieh Hu, Roberta A. Mittelstaedt, Raul A. Trbojevich, Susan Chemerynski, Melis Coraggio, R. Philip Yeager, Sherry M. Lewis, Hans Rosenfeldt, Yunan Tang, Guy Lagaud, Kelly Davis, Matthew Bryant, Estatira Sepehr, Michelle E. Bishop, Darshan Mehta, Hyun-Ki Kang, Paul C. Howard
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 182(1)
The tobacco-specific nitrosamine NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone] is found in tobacco products and tobacco smoke. NNK is a potent genotoxin and human lung carcinogen; however, there are limited inhalation data for the toxicokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1e2fb074fc320703778d60af9c92d0
https://pubmed.ncbi.nlm.nih.gov/33944952
https://pubmed.ncbi.nlm.nih.gov/33944952
Autor:
Xiaoqing Guo, Roberta A. Mittelstaedt, Nan Mei, Yan Li, Robert H. Heflich, Javed A. Bhalli, Joseph G. Shaddock, Patricia Richter, M. De
Publikováno v:
Mutation research. Genetic toxicology and environmental mutagenesis. 866
Dose-response modeling of in vitro micronucleus test (IVMNT) data was evaluated to determine if the approach has value in discriminating among different tobacco products. Micronucleus responses were generated in L5178Y/Tk+/- mouse lymphoma cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887d93f70318ad5201b9ef6956bd2ddd
https://pubmed.ncbi.nlm.nih.gov/33985695
https://pubmed.ncbi.nlm.nih.gov/33985695
Autor:
Vasily N, Dobrovolsky, Joseph G, Shaddock, Roberta A, Mittelstaedt, Daishiro, Miura, Robert H, Heflich
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2031
Assays for in vivo mutation are used to identify genotoxic hazards and phenotypes prone to genomic instability and cancer. The hypoxanthine guanine phosphoribosyl transferase (Hprt) gene and the phosphatidyl inositol glycan, class A (Pig-a) gene are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e64b99ad33b98524991883f0942dbb69
https://pubmed.ncbi.nlm.nih.gov/31473954
https://pubmed.ncbi.nlm.nih.gov/31473954