Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Roberta A, Gottlieb"'
Autor:
Parisa Koutsifeli, Lorna J. Daniels, Joshua Neale, Sarah Fong, Upasna Varma, Marco Annandale, Xun Li, Yohanes Nursalim, James R. Bell, Kate L. Weeks, Aleksandr Stotland, David J. Taylor, Roberta A. Gottlieb, Lea M.D. Delbridge, Kimberley M. Mellor
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Glycogen-autophagy (‘glycophagy’) is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycogen cargo
Externí odkaz:
https://doaj.org/article/896be00534814dda8ffacc5947942049
Autor:
Gautham Yepuri, Lisa M. Ramirez, Gregory G. Theophall, Sergei V. Reverdatto, Nosirudeen Quadri, Syed Nurul Hasan, Lei Bu, Devi Thiagarajan, Robin Wilson, Raquel López Díez, Paul F. Gugger, Kaamashri Mangar, Navneet Narula, Stuart D. Katz, Boyan Zhou, Huilin Li, Aleksandr B. Stotland, Roberta A. Gottlieb, Ann Marie Schmidt, Alexander Shekhtman, Ravichandran Ramasamy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Inter-organelle contact and communication between mitochondria and sarco/endoplasmic reticulum (SR/ER) maintain cellular homeostasis and are profoundly disturbed during tissue ischemia. We tested the hypothesis that the formin Diaphanous-1 (
Externí odkaz:
https://doaj.org/article/afb308148fa9402ea6f6e0d25ae3c38d
Autor:
Tsunenori Saito, Naoko Saito Sato, Kosuke Mozawa, Akiko Adachi, Yoshihiro Sasaki, Kotoka Nakamura, Eiichiro Oka, Toshiaki Otsuka, Eitaro Kodani, Kuniya Asai, Kyoichi Mizuno, Wataru Shimizu, Roberta A. Gottlieb
Publikováno v:
ESC Heart Failure, Vol 8, Iss 6, Pp 5178-5191 (2021)
Abstract Aims The aim of the present study was to consider whether the ultrastructural features of cardiomyocytes in dilated cardiomyopathy can be used to guide genetic testing. Methods and results Endomyocardial biopsy and whole‐exome sequencing w
Externí odkaz:
https://doaj.org/article/2bae72efb5c54cd899bb402878691bd3
Autor:
Savannah Sawaged, Thomas Mota, Honit Piplani, Reetu Thakur, Deepti Lall, Elizabeth McCabe, Soojung Seo, Fayyaz S Sutterwala, Ralph Feuer, Roberta A Gottlieb, Jon Sin
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010350 (2022)
Host-pathogen dynamics are constantly at play during enteroviral infection. Coxsackievirus B (CVB) is a common juvenile enterovirus that infects multiple organs and drives inflammatory diseases including acute pancreatitis and myocarditis. Much like
Externí odkaz:
https://doaj.org/article/e696c9c12bf5439ba9dabcd41437eaa3
Autor:
Juliana de F. Germano, Chengqun Huang, Jon Sin, Yang Song, Kyle C. Tucker, David J. R. Taylor, Hannaneh Saadaeijahromi, Aleksandr Stotland, Honit Piplani, Roberta A. Gottlieb, Robert M. Mentzer, Allen M. Andres
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Given that adverse remodeling is the leading cause of heart failure and death in the USA, there is an urgent unmet need to develop new methods in dealing with this devastating disease. Here we evaluated the efficacy of a short-course glucago
Externí odkaz:
https://doaj.org/article/bdb64149fffc46618c22d0b61e814c7a
Autor:
Stefanie Marek-Iannucci, Asli B. Ozdemir, Debbie Moreira, Angela C. Gomez, Malcolm Lane, Rebecca A. Porritt, Youngho Lee, Kenichi Shimada, Masanori Abe, Aleksandr Stotland, David Zemmour, Sarah Parker, Elsa Sanchez-Lopez, Jennifer Van Eyk, Roberta A. Gottlieb, Michael C. Fishbein, Michael Karin, Timothy R. Crother, Magali Noval Rivas, Moshe Arditi
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Kawasaki disease (KD) is the leading cause of acquired heart disease among children. Murine and human data suggest that the NLRP3–IL-1β pathway is the main driver of KD pathophysiology. NLRP3 can be activated during defective autophagy/mitophagy.
Externí odkaz:
https://doaj.org/article/8c3c23459c15468788622df34392f6d5
Autor:
Ana Florencia Casassa, María Cristina Vanrell, María Isabel Colombo, Roberta A. Gottlieb, Patricia Silvia Romano
Publikováno v:
Virulence, Vol 10, Iss 1, Pp 151-165 (2019)
Autophagy is a catabolic pathway required for cellular and organism homeostasis. Autophagy participates in the innate and adaptive immune responses at different levels. Xenophagy is a class of selective autophagy that involves the elimination of intr
Externí odkaz:
https://doaj.org/article/340625eabe3c47aeab5cb440c0d4e569
Autor:
Qinglan Wang, Zhijun Wang, Mingyi Xu, Wei Tu, I-Fang Hsin, Aleksandr Stotland, Jeong Han Kim, Ping Liu, Mitsuru Naiki, Roberta A. Gottlieb, Ekihiro Seki
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The accumulation of lipid droplets in the cytoplasm of hepatocytes, known as hepatic steatosis, is a hallmark of non-alcoholic fatty liver disease (NAFLD). Inhibiting hepatic steatosis is suggested to be a therapeutic strategy for NAFLD. The present
Externí odkaz:
https://doaj.org/article/9e8b1fa7ad5b4dd79d23adc1ec5ccdd6
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
RationaleAdverse remodeling leads to heart failure after myocardial infarction (MI), with important impact on morbidity and mortality. New therapeutic approaches are needed to further improve and broaden heart failure therapy. We established a minima
Externí odkaz:
https://doaj.org/article/64f4e6d0212f4437ba7d65f43b9a4836
Autor:
Amandine Thomas, Stefanie Marek-Iannucci, Kyle C. Tucker, Allen M. Andres, Roberta A. Gottlieb
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2020)
Mitophagy plays a major role in heart physiology. Impairment of Parkin-dependent mitophagy in heart is known to be deleterious. Obesity is a known cardiovascular risk factor. Impaired autophagy has been reported in models of obesity or hyperlipidemia
Externí odkaz:
https://doaj.org/article/752dcb5753a84f0b8991c86b6e32a347