Výsledky vyhledávání - "Roberta, Cereda"

HPLC-MS/MS method for quantitative determination of the novel dual inhibitor of FGF and VEGF receptors E-3810 in tumor tissues from xenograft mice and human biopsies

Autor: Laura Ceriani, Monique Zangarini, Giovanna Damia, Massimo Zucchetti, Ezia Bello, Roberta Cereda, M. G. Camboni

Publikováno v: Journal of Mass Spectrometry. 49:19-26

We developed and validated a high-performance liquid chromatography–tandem mass spectrometry analytical method to measure E-3810, a novel dual inhibitor of fibroblast growth factor receptor 1 and vascular endothelial growth factor receptor 1–3 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::914853226a0005b15b8e34a3583d0100
https://doi.org/10.1002/jms.3305

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A first in human phase I study of the proteasome inhibitor CEP-18770 in patients with advanced solid tumours and multiple myeloma

Autor: Maurizio D'Incalci, Cristina Noberasco, Silvia Marsoni, Roberta Cereda, Elena Marangon, D. Brunelli, Cristiana Sessa, Giovanni Martinelli, Angelo Delmonte, Steffen Böhm, Filippo de Braud, Elisa Gallerani, Massimo Zucchetti, Federica Sala, Dagmar Hess, Christopher Driessen

Publikováno v: European Journal of Cancer. 49:290-296

Background The safety, pharmacokinetics (PK) and pharmacodynamics of CEP-18770, a new peptide boronic acid proteasome inhibitor, have been investigated after intravenous administration on days 1, 4, 8 and 11 of every 21 d cycle in patients with solid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f325578b9e7f5b2737efe7c4f852f58
https://doi.org/10.1016/j.ejca.2012.09.009

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Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the determination of the novel inhibitor of angiogenesis E-3810 in human plasma and its application in a clinical pharmacokinetic study

Autor: Renzo Bagnati, Federica Sala, Maurizio D'Incalci, Roberta Cereda, Massimo Zucchetti, Valeria Livi

Publikováno v: Journal of Mass Spectrometry. 46:1039-1045

E-3810, 6-[[7-[(1-aminocyclopropyl)methoxy]-6-methoxy-4-quinolyl]oxy]-N-methyl-naphthalene-1-carboxamide, is a novel, potent, dual inhibitor of vascular endothelial growth factor and fibroblast growth factor receptors with antiangiogenic properties,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18efeadde2e746864d554d820a29106
https://doi.org/10.1002/jms.1985

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Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the determination of the novel proteasome inhibitor CEP-18770 in human plasma and its application in a clinical pharmacokinetic study

Autor: Elena Marangon, Federica Sala, Renzo Bagnati, Maurizio D'Incalci, Massimo Zucchetti, Roberta Cereda, Valeria Livi

Publikováno v: Journal of Mass Spectrometry. 45:1299-1305

CEP-18770, [(1R)-1-{[(2S,3R)-3-hydroxy-2-{[(6-phenyl-2-pyridinyl)carbonyl]amino}butanoyl]amino}-3-methylbutyl]boronic acid, is a novel proteasome inhibitor, now under early clinical evaluation as an anticancer agent. To investigate its clinical pharm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8f44c7afde4f36632ef9462c8272d3
https://doi.org/10.1002/jms.1842

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Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors

Autor: Massimo Zucchetti, F. Debraud, Maurizio D'Incalci, Andrew R. Allen, Josep Tabernero, B. Adamo, Ratislav Bahleda, Renata Robert, Angelo Delmonte, M. G. Camboni, Jean-Charles Soria, R. Dientsmann, Fabrice Andre, Jeffrey D. Isaacson, C. Saba, Jason B. Litten, Roberta Cereda, F. Dubois

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 25(11)

Background Lucitanib is a potent, oral inhibitor fibroblast growth factor receptor types 1 and 2 (FGFR), vascular endothelial growth factor receptor types 1, 2, and 3 (VEGFR), platelet-derived growth factor receptor types α and β (PGFRα/β), which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d996f8e8b1f4d889e388989e50e7bea
https://pubmed.ncbi.nlm.nih.gov/32590894

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HPLC-MS/MS method for quantitative determination of the novel dual inhibitor of FGF and VEGF receptors E-3810 in tumor tissues from xenograft mice and human biopsies

Autor: Monique, Zangarini, Laura, Ceriani, Ezia, Bello, Giovanna, Damia, Roberta, Cereda, Maria Gabriella, Camboni, Massimo, Zucchetti

Publikováno v: Journal of mass spectrometry : JMS. 49(1)

We developed and validated a high-performance liquid chromatography-tandem mass spectrometry analytical method to measure E-3810, a novel dual inhibitor of fibroblast growth factor receptor 1 and vascular endothelial growth factor receptor 1-3 in tis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0a14a03c454a99957893953ad66a9f2
https://pubmed.ncbi.nlm.nih.gov/24446259

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New Antianginal Nitro Esters with Reduced Hypotensive Activity. Synthesis and Pharmacological Evaluation of 3-[(Nitrooxy)alkyl]-2H-1,3-benzoxazin-4(3H)-ones

Autor: Gianni Gromo, Roberta Cereda, Jacques Mizrahi, Alberto Sala, Francesca Benedini, Giancarlo Dona, Giorgio Bertolini, Silvio Levi

Publikováno v: Journal of Medicinal Chemistry. 38:130-136

New nitro ester 3-[(nitrooxy)alkyl]-2H-1,3-benzoxazin-4(3H)-ones show marked inhibitory activity against ischemia-induced electrocardiographic changes, with only limited systemic hemodynamic effects, and are reported in the present study. These new n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26bfbcc9fb526445365b8224a6ae7a4
https://doi.org/10.1021/jm00001a018

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Protective Effect of the Nitrate Ester ITF 296 Against

Autor: Jacques Mizrahi, Gianni Gromo, Silvio Agozzino, Mario Bergamaschi, Gabriele Mascheroni, Fabio Bravi, Roberta Cereda

Publikováno v: Journal of Cardiovascular Pharmacology. 26:S37-43

The activity of ITF 296 against methacholine-induced myocardial ischemia was investigated in anesthetized rats in comparison with the organic nitrates nitroglycerin (NTG) and isosorbide dinitrate (ISDN), the K(+)-channel openers nicorandil and cromak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2f0fb7fed391b72e19866a8ea317d0
https://doi.org/10.1097/00005344-199526004-00008

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Significant Antitumor Activity of E-3810, a Novel FGFR and VEGFR Inhibitor, in Patients With FGFR1 Amplified Breast Cancer

Autor: Rodrigo Dienstmann, F. de Braud, Ratislav Bahleda, J-C. Soria, Roberta Cereda, Antoine Hollebecque, J. Tabernero, M. G. Camboni, Fabrice Andre, Angelo Delmonte

Publikováno v: Annals of Oncology. 23:ix116-ix117

Background Amplification of the FGFR1 gene occurs in subsets of tumors, notably breast cancer (BC), where the altered FGF pathway may be clinically relevant. Methods E-3810 is a kinase inhibitor targeting FGFR1 and VEGFR1, 2, 3. Its safety and activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e631d0e27098598cc183ae7237970c1
https://doi.org/10.1016/s0923-7534(20)32898-2

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