Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Robert-Jan Palstra"'
Autor:
Tanvir Hossain, Cynthia Lungu, Sten de Schrijver, Mamokoena Kuali, Raquel Crespo, Nicole Reddy, Ayanda Ngubane, Tsung Wai Kan, Kavidha Reddy, Shringar Rao, Robert-Jan Palstra, Paradise Madlala, Thumbi Ndung’u, Tokameh Mahmoudi
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-16 (2024)
Abstract Background Strategies toward HIV-1 cure aim to clear, inactivate, reduce, or immunologically control the virus from a pool of latently infected cells such that combination antiretroviral therapy (cART) can be safely interrupted. In order to
Externí odkaz:
https://doaj.org/article/96ec68967979482ebfb2e9618aa6e80f
Autor:
Raquel Crespo, Enrico Ne, Julian Reinders, Jenny I.J. Meier, Chengcheng Li, Sanne Jansen, Alicja Górska, Selin Koçer, Tsung Wai Kan, Wouter Doff, Dick Dekkers, Jeroen Demmers, Robert-Jan Palstra, Shringar Rao, Tokameh Mahmoudi
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109152- (2024)
Summary: HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a subunit of the transcription and export complex 2 (TREX2)
Externí odkaz:
https://doaj.org/article/0e18451e6098468fa753157044bce967
Autor:
Shringar Rao, Cynthia Lungu, Raquel Crespo, Thijs H. Steijaert, Alicja Gorska, Robert-Jan Palstra, Henrieke A. B. Prins, Wilfred van Ijcken, Yvonne M. Mueller, Jeroen J. A. van Kampen, Annelies Verbon, Peter D. Katsikis, Charles A. B. Boucher, Casper Rokx, Rob A. Gruters, Tokameh Mahmoudi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
DEAD-box polypeptide 3 (DDX3) is a host protein belonging to the family of ATP-dependent RNA helicases. Here, the authors demonstrate that DDX3 inhibitors reverse HIV-1 latency and selectively induce cell death in HIV-1-infected cell lines, primary C
Externí odkaz:
https://doaj.org/article/983a234271bf4954b9536cec417f77df
Autor:
Michael Röling, Mahsa Mollapour Sisakht, Enrico Ne, Panagiotis Moulos, Raquel Crespo, Mateusz Stoszko, Elisa De Crignis, Helen Bodmer, Tsung Wai Kan, Maryam Akbarzadeh, Vaggelis Harokopos, Pantelis Hatzis, Robert-Jan Palstra, Tokameh Mahmoudi
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat). Following mutagenesis, insertions were map
Externí odkaz:
https://doaj.org/article/2f729d806387452999a3c9f51ee0ea9f
Autor:
Elisa De Crignis, Tanvir Hossain, Shahla Romal, Fabrizia Carofiglio, Panagiotis Moulos, Mir Mubashir Khalid, Shringar Rao, Ameneh Bazrafshan, Monique MA Verstegen, Farzin Pourfarzad, Christina Koutsothanassis, Helmuth Gehart, Tsung Wai Kan, Robert-Jan Palstra, Charles Boucher, Jan NM IJzermans, Meritxell Huch, Sylvia F Boj, Robert Vries, Hans Clevers, Luc JW van der Laan, Pantelis Hatzis, Tokameh Mahmoudi
Publikováno v:
eLife, Vol 10 (2021)
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the use of human liver organoids as a platform for
Externí odkaz:
https://doaj.org/article/14b4dd868a334facbdb13052dadd9b22
Autor:
Mateusz Stoszko, Elisa De Crignis, Casper Rokx, Mir Mubashir Khalid, Cynthia Lungu, Robert-Jan Palstra, Tsung Wai Kan, Charles Boucher, Annelies Verbon, Emily C. Dykhuizen, Tokameh Mahmoudi
Publikováno v:
EBioMedicine, Vol 3, Iss C, Pp 108-121 (2016)
Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cel
Externí odkaz:
https://doaj.org/article/63201ca417954753afb8c06cb24c4a67
Autor:
Robert-Jan Palstra, Marieke Simonis, Petra Klous, Emilie Brasset, Bart Eijkelkamp, Wouter de Laat
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1661 (2008)
A relationship exists between nuclear architecture and gene activity and it has been proposed that the activity of ongoing RNA polymerase II transcription determines genome organization in the mammalian cell nucleus. Recently developed 3C and 4C tech
Externí odkaz:
https://doaj.org/article/6c20841274ce4eeb902b2f25ae178e37
Autor:
Enrico Ne, Raquel Crespo, Ray Izquierdo-Lara, Shringar Rao, Selin Koçer, Alicja Górska, Thomas van Staveren, Tsung Wai Kan, David van de Vijver, Dick Dekkers, Casper Rokx, Panagiotis Moulos, Pantelis Hatzis, Robert-Jan Palstra, Jeroen Demmers, Tokameh Mahmoudi
Publikováno v:
Nucleic Acids Research, 50(10), 5577-5598. Oxford University Press
A major pharmacological strategy toward HIV cure aims to reverse latency in infected cells as a first step leading to their elimination. While the unbiased identification of molecular targets physically associated with the latent HIV-1 provirus would
Autor:
Henrieke A. B. Prins, Raquel Crespo, Cynthia Lungu, Shringar Rao, Letao Li, Ronald J. Overmars, Grigorius Papageorgiou, Yvonne M. Mueller, Mateusz Stoszko, Tanvir Hossain, Tsung Wai Kan, Bart J. A. Rijnders, Hannelore I. Bax, Eric C. M. van Gorp, Jan L. Nouwen, Theodora E. M. S. de Vries-Sluijs, Carolina A. M. Schurink, Mariana de Mendonça Melo, Els van Nood, Angela Colbers, David Burger, Robert-Jan Palstra, Jeroen J. A. van Kampen, David A. M. C. van de Vijver, Thibault Mesplède, Peter D. Katsikis, Rob A. Gruters, Birgit C. P. Koch, Annelies Verbon, Tokameh Mahmoudi, Casper Rokx
Publikováno v:
Science Advances, 9
Science Advances, 9, 11
Science advances, 9(11):eade6675. American Association for the Advancement of Science
Science Advances, 9, 11
Science advances, 9(11):eade6675. American Association for the Advancement of Science
Contains fulltext : 291084.pdf (Publisher’s version ) (Open Access) Reactivation of the latent HIV-1 reservoir is a first step toward triggering reservoir decay. Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the res
Autor:
Tokameh Mahmoudi, Monique M.A. Verstegen, Tanvir Hossain, Pantelis Hatzis, Robert P. de Vries, Jan Nm IJzermans, Mir M. Khalid, Elisa De Crignis, Shahla Romal, Tsung Wai Kan, Helmuth Gehart, Christina Koutsothanassis, Luc J. W. van der Laan, Shringar Rao, Meritxell Huch, Farzin Pourfarzad, Robert-Jan Palstra, Sylvia F. Boj, Charles A. Boucher, Panagiotis Moulos, Ameneh Bazrafshan, Fabrizia Carofiglio, Hans Clevers
Publikováno v:
eLife, Vol 10 (2021)
eLife, 10. eLife Sciences Publications
eLife, 10
eLife
eLife, 10. eLife Sciences Publications
eLife, 10
eLife
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the use of human liver organoids as a platform for