Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Robert-Jan Doll"'
Autor:
Ahnjili Zhuparris, Ghobad Maleki, Liesbeth van Londen, Ingrid Koopmans, Vincent Aalten, Iris E. Yocarini, Vasileios Exadaktylos, Albert van Hemert, Adam Cohen, Pim Gal, Robert-Jan Doll, Geert Jan Groeneveld, Gabriël Jacobs, Wessel Kraaij
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Drug development for mood disorders can greatly benefit from the development of robust, reliable, and objective biomarkers. The incorporation of smartphones and wearable devices in clinical trials provide a unique opportunity to monitor beha
Externí odkaz:
https://doaj.org/article/7fc77d26e65c4a94b6761c3ca90e1519
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract Background In the current study, we aimed to develop an algorithm based on biomarkers obtained through non- or minimally invasive procedures to identify healthy elderly subjects who have an increased risk of abnormal cerebrospinal fluid (CSF
Externí odkaz:
https://doaj.org/article/a7689931f0644552b7feafa5d357d2b7
Publikováno v:
Neuromodulation, 25(7), 1006-1014. Elsevier
Objectives: There is a lack of clinically relevant measures for quantification of maladaptive mechanisms of the nociceptive system leading to chronic pain. Recently, we developed a method that tracks nociceptive detection thresholds (NDTs) using intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f418b92e3c05f60d418dede61445a97
http://www.scopus.com/inward/record.url?scp=85124842913&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85124842913&partnerID=8YFLogxK
Autor:
Hemme Hijma, Ingrid Koopmans, Erica Klaassen, Robert Jan Doll, Rob Zuiker, Geert Jan Groeneveld
Publikováno v:
British Journal of Clinical Pharmacology. WILEY
British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology
Aim: We assessed whether total sleep deprivation (TSD) in combination with pain tests yields a reliable method to assess altered pain thresholds, which subsequently may be used to investigate (novel) analgesics in healthy subjects. Methods: This was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c870fe4bea324c7d5f9946f41924fab7
https://hdl.handle.net/1887/3572118
https://hdl.handle.net/1887/3572118
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Alzheimer's Research and Therapy
ISSUE=13;TITLE=Alzheimer's Research and Therapy
Alzheimer's Research & Therapy
Alzheimer's Research and Therapy
ISSUE=13;TITLE=Alzheimer's Research and Therapy
Alzheimer's Research & Therapy
Background In the current study, we aimed to develop an algorithm based on biomarkers obtained through non- or minimally invasive procedures to identify healthy elderly subjects who have an increased risk of abnormal cerebrospinal fluid (CSF) amyloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef4752884b7bcac1c3c08a9e35adefa
https://doaj.org/article/a7689931f0644552b7feafa5d357d2b7
https://doaj.org/article/a7689931f0644552b7feafa5d357d2b7
Autor:
Hein E.C. van der Wall, Gert-Jan Hassing, Robert-Jan Doll, Gerard J.P. van Westen, Adam F. Cohen, Jasper L. Selder, Michiel Kemme, Jacobus Burggraaf, Pim Gal
Publikováno v:
van der Wall, H E C, Hassing, G-J, Doll, R-J, van Westen, G J P, Cohen, A F, Selder, J L, Kemme, M, Burggraaf, J & Gal, P 2022, ' Cardiac age detected by machine learning applied to the surface ECG of healthy subjects : Creation of a benchmark ', Journal of Electrocardiology, vol. 72, pp. 49-55 . https://doi.org/10.1016/j.jelectrocard.2022.03.001
Journal of Electrocardiology, 72, 49-55
Journal of Electrocardiology, 72, 49-55. Churchill Livingstone
Journal of Electrocardiology, 72, 49-55
Journal of Electrocardiology, 72, 49-55. Churchill Livingstone
ObjectiveThe aim of the present study was to develop a neural network to characterize the effect of aging on the ECG in healthy volunteers. Moreover, the impact of the various ECG features on aging was evaluated.Methods & resultsA total of 6228 healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779640398559231932119e59ea21b8cc
https://research.vumc.nl/en/publications/5b8aa767-9e2a-479e-bbff-ce518ae65d81
https://research.vumc.nl/en/publications/5b8aa767-9e2a-479e-bbff-ce518ae65d81
Autor:
Ingrid Koopmans, Robert-Jan Doll, Hein van der Wall, Marieke de Kam, Geert Jan Groeneveld, Adam Cohen, Rob Zuiker
Publikováno v:
PLOS ONE. 18:e0278300
Introduction Drivers should be aware of possible impairing effects of alcohol, medicinal substance, or fatigue on driving performance. Such effects are assessed in clinical trials, including a driving task or related psychomotor tasks. However, a cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71260509c3ee1efe7e3b96f13a5b5201
https://doi.org/10.1371/journal.pone.0278300
https://doi.org/10.1371/journal.pone.0278300
Autor:
Ahnjili ZhuParris, Matthijs D. Kruizinga, Max van Gent, Eva Dessing, Vasileios Exadaktylos, Robert Jan Doll, Frederik E. Stuurman, Gertjan A. Driessen, Adam F. Cohen
Publikováno v:
Frontiers in Pediatrics, 9. FRONTIERS MEDIA
Frontiers in pediatrics, 9:651356. Frontiers Media S.A.
Frontiers in Pediatrics, Vol 9 (2021)
Frontiers in Pediatrics
Frontiers in Pediatrics, 9. FRONTIERS MEDIA SA
Frontiers in pediatrics, 9:651356. Frontiers Media S.A.
Frontiers in Pediatrics, Vol 9 (2021)
Frontiers in Pediatrics
Frontiers in Pediatrics, 9. FRONTIERS MEDIA SA
Introduction: The duration and frequency of crying of an infant can be indicative of its health. Manual tracking and labeling of crying is laborious, subjective, and sometimes inaccurate. The aim of this study was to develop and technically validate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29eba6ca00256d078a96d6841eead8d5
https://cris.maastrichtuniversity.nl/en/publications/bc8decaa-8ee4-4ac4-b68a-1bf65f7ebce2
https://cris.maastrichtuniversity.nl/en/publications/bc8decaa-8ee4-4ac4-b68a-1bf65f7ebce2
Autor:
Charlotte, Bakker, Tim, Tasker, Jan, Liptrot, Ellen P, Hart, Erica S, Klaassen, Robert Jan, Doll, Giles A, Brown, Alastair, Brown, Miles, Congreve, Malcolm, Weir, Fiona H, Marshall, David M, Cross, Geert Jan, Groeneveld, Pradeep J, Nathan
Publikováno v:
Alzheimer's Research & Therapy
Background The cholinergic system and M1 receptor remain an important target for symptomatic treatment of cognitive dysfunction. The selective M1 receptor partial agonist HTL0018318 is under development for the symptomatic treatment of Dementia’s i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f321965e92eabde84ef76a2dcf9e89b0
https://pubmed.ncbi.nlm.nih.gov/33883008
https://pubmed.ncbi.nlm.nih.gov/33883008
Autor:
Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P. Hart, Erica S. Klaassen, Robert Jan Doll, Giles A. Brown, Alastair Brown, Miles Congreve, Malcolm Weir, Fiona H. Marshall, David M. Cross, Geert Jan Groeneveld, Pradeep J. Nathan
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background The cholinergic system and M1 receptor remain an important target for symptomatic treatment of cognitive dysfunction. The selective M1 receptor partial agonist HTL0018318 is under development for the symptomatic treatment of Demen
Externí odkaz:
https://doaj.org/article/8f25b2ca13ee46c9988b118de2ad5f58