Zobrazeno 1 - 10
of 521
pro vyhledávání: '"Robert Zimmermann"'
Autor:
Johanna M. Kohlmayr, Gernot F. Grabner, Anna Nusser, Anna Höll, Verina Manojlović, Bettina Halwachs, Sarah Masser, Evelyne Jany-Luig, Hanna Engelke, Robert Zimmermann, Ulrich Stelzl
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract ATGL is a key enzyme in intracellular lipolysis and plays an important role in metabolic and cardiovascular diseases. ATGL is tightly regulated by a known set of protein-protein interaction partners with activating or inhibiting functions in
Externí odkaz:
https://doaj.org/article/8165068aa9f84cc9a342357d36af3744
Autor:
Francisco J. Medrano, Sergio de la Hoz-Rodríguez, Sergio Martí, Kemel Arafet, Tanja Schirmeister, Stefan J. Hammerschmidt, Christin Müller, Águeda González-Martínez, Elena Santillana, John Ziebuhr, Antonio Romero, Collin Zimmer, Annabelle Weldert, Robert Zimmermann, Alessio Lodola, Katarzyna Świderek, Vicent Moliner, Florenci V. González
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public health issue. The viral main protease (Mpro) represents one of the most attractive targets for the development of antiviral drugs. Herein we report pepti
Externí odkaz:
https://doaj.org/article/3ea31cb9aaef4184b8998a4dd4345a66
Autor:
Peter Hofer, Gernot F. Grabner, Mario König, Hao Xie, Dominik Bulfon, Anton E. Ludwig, Heimo Wolinski, Robert Zimmermann, Rudolf Zechner, Christoph Heier
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100457- (2023)
Intracellular lipolysis—the enzymatic breakdown of lipid droplet-associated triacylglycerol (TAG)—depends on the cooperative action of several hydrolytic enzymes and regulatory proteins, together designated as lipolysome. Adipose triglyceride lip
Externí odkaz:
https://doaj.org/article/bfc34bab37db460bab35c37681986747
Autor:
Armin Gerbitz, Regina Gary, Michael Aigner, Andreas Moosmann, Anita Kremer, Christoph Schmid, Klaus Hirschbuehl, Eva Wagner, Beate Hauptrock, Daniel Teschner, Wolf Roesler, Bernd Spriewald, Johanna Tischer, Stephanie Moi, Heidi Balzer, Stefanie Schaffer, Judith Bausenwein, Anja Wagner, Franziska Schmidt, Jens Brestrich, Barbara Ullrich, Stefanie Maas, Susanne Herold, Julian Strobel, Robert Zimmermann, Volker Weisbach, Leo Hansmann, Fernanda Lammoglia-Cobo, Mats Remberger, Matthias Stelljes, Francis Ayuk, Robert Zeiser, Andreas Mackensen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionAllogeneic stem cell transplantation is used to cure hematologic malignancies or deficiencies of the hematopoietic system. It is associated with severe immunodeficiency of the host early after transplant and therefore early reactivation o
Externí odkaz:
https://doaj.org/article/dc8f3dfc560543468eff1c7f11a60fbd
Autor:
Eva Jarc Jovičić, Anja Pucer Janež, Thomas O. Eichmann, Špela Koren, Vesna Brglez, Paul M. Jordan, Jana Gerstmeier, Duško Lainšček, Anja Golob-Urbanc, Roman Jerala, Gérard Lambeau, Oliver Werz, Robert Zimmermann, Toni Petan
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101791- (2023)
Objectives: Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids and precursors of oxygenated lipid mediators with diverse functions, including the control of cell growth, inflammation and tumourigenesis. However, t
Externí odkaz:
https://doaj.org/article/69a7f99ca7a2431890b61a103932e25e
Autor:
Valentina Bianco, Melanie Korbelius, Nemanja Vujic, Alena Akhmetshina, Melina Amor, Dagmar Kolb, Anita Pirchheim, Ivan Bradic, Katharina B. Kuentzel, Martin Buerger, Silvia Schauer, Huyen T.T. Phan, Dominik Bulfon, Gerald Hoefler, Robert Zimmermann, Dagmar Kratky
Publikováno v:
Molecular Metabolism, Vol 73, Iss , Pp 101737- (2023)
Objective: To date, the only enzyme known to be responsible for the hydrolysis of cholesteryl esters and triacylglycerols in the lysosome at acidic pH is lysosomal acid lipase (LAL). Lipid malabsorption in the small intestine (SI), accompanied by mac
Externí odkaz:
https://doaj.org/article/56fe92f78f8e4d238b80e8bd6cd05e8b
Autor:
Natascha Berger, Tom van der Wel, Birgit Hirschmugl, Thomas Baernthaler, Juergen Gindlhuber, Nermeen Fawzy, Thomas Eichmann, Ruth Birner-Gruenberger, Robert Zimmermann, Mario van der Stelt, Christian Wadsack
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionLipids and fatty acids are key components in metabolic processes of the human placenta, thereby contributing to the development of the fetus. Placental dyslipidemia and aberrant activity of lipases have been linked to diverse pregnancy as
Externí odkaz:
https://doaj.org/article/554df234a0eb4e46ba913fb591099917
Autor:
Maaike E. Straat, Lucas Jurado-Fasoli, Zhixiong Ying, Kimberly J. Nahon, Laura G.M. Janssen, Mariëtte R. Boon, Gernot F. Grabner, Sander Kooijman, Robert Zimmermann, Martin Giera, Patrick C.N. Rensen, Borja Martinez-Tellez
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104349- (2022)
Summary: Background: The application of cold exposure has emerged as an approach to enhance whole-body lipid catabolism. The global effect of cold exposure on the lipidome in humans has been reported with mixed results depending on intensity and dura
Externí odkaz:
https://doaj.org/article/41b32167ac664f08b061629b0be5b4ed
Autor:
Ivan Bradić, Katharina B. Kuentzel, Sophie Honeder, Gernot F. Grabner, Nemanja Vujić, Robert Zimmermann, Ruth Birner-Gruenberger, Dagmar Kratky
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101510- (2022)
Objectives: Lysosomal acid lipase (LAL) is the key enzyme, which degrades neutral lipids at an acidic pH in lysosomes. The role of LAL in various cellular processes has mostly been studied in LAL-knockout mice, which share phenotypical characteristic
Externí odkaz:
https://doaj.org/article/9e9a94ef33d94480bffc59576b063088
Autor:
Robert Anton Kramer, Robert Zimmermann, Julian Strobel, Susanne Achenbach, Armin Michael Ströbel, Holger Hackstein, David Alexander Christian Messerer, Sabine Schneider
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7976 (2023)
Prothrombotic hereditary risk factors for cerebral vein thrombosis (CVT) are of clinical interest to better understand the underlying pathophysiology and stratify patients for the risk of recurrence. This study explores prothrombotic risk factors in
Externí odkaz:
https://doaj.org/article/889f63d0c9344253af6fd263b2379add