Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Robert Z. Florkiewicz"'
Autor:
Bradley W. Doble, James R. Davie, Jian-Min Sun, Peter A. Cattini, Guangping Sun, Elissavet Kardami, Robert R. Fandrich, Lorrie A. Kirshenbaum, Robert Z. Florkiewicz
Publikováno v:
Journal of Cellular Physiology. 186:457-467
Fibroblast growth factor-2 (FGF-2) is a mitogen found in CUG-initiated 21-25 kDa ("hi") or AUG-initiated 16-18 kDa ("lo") forms. Previously we demonstrated that "hi"-but not "lo"-FGF-2 caused a distinct nuclear phenotype characterized by apparently c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57234382d2a55c4fb25667a1c66ea0f1
https://doi.org/10.1002/1097-4652(2000)9999:999<000::aid-jcp1044>3.0.co
https://doi.org/10.1002/1097-4652(2000)9999:999<000::aid-jcp1044>3.0.co
Publikováno v:
Journal of Cellular Physiology. 185:260-268
Like most cells in culture, stably transfected COS-1 cells (CF18) that constitutively overexpress basic fibroblast growth factor (FGF2) do not release the growth factor into conditioned media. Yet, when cells were biotinylated, 30% of the total cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3022dcdbaaa854de8f40e21da9f98ca
https://doi.org/10.1002/1097-4652(200011)185:2<260::aid-jcp11>3.0.co
https://doi.org/10.1002/1097-4652(200011)185:2<260::aid-jcp11>3.0.co
Autor:
Erica Kratz, John Moffett, Ewa K. Stachowiak, Michal K. Stachowiak, Jason Myers, Robert Z. Florkiewicz
Publikováno v:
Molecular Biology of the Cell. 9:2269-2285
Induction of the fibroblast growth factor-2 (FGF-2) gene and the consequent accumulation of FGF-2 in the nucleus are operative events in mitotic activation and hypertrophy of human astrocytes. In the brain, these events are associated with cellular d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104f8935884704ae986d041487630823
https://doi.org/10.1091/mbc.9.8.2269
https://doi.org/10.1091/mbc.9.8.2269
Publikováno v:
Proceedings of the National Academy of Sciences. 93:2470-2475
Expression of mitogenic basic fibroblast growth factor (bFGF) in the central nervous system is inhibited by direct cell contact and is implicated in reactive and neoplastic transformation of astrocytes. The molecular mechanisms controlling expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74293c69675a649e7842a5b78fabe8e0
https://doi.org/10.1073/pnas.93.6.2470
https://doi.org/10.1073/pnas.93.6.2470
Autor:
Rebecca Z. German, A Kier, Robert Z. Florkiewicz, P Lightfoot, B A O'Toole, nd G W Dorn, J Neumann, P N Howles, T Mort-Hopkins, J D Coffin
Publikováno v:
Molecular Biology of the Cell. 6:1861-1873
Basic fibroblast growth factor (FGF-2) is a pleiotropic growth factor detected in many different cells and tissues. Normally synthesized at low levels, FGF-2 is elevated in various pathologies, most notably in cancer and injury repair. To investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e372bbc066ebeafd0fdf32e169a1654
https://doi.org/10.1091/mbc.6.12.1861
https://doi.org/10.1091/mbc.6.12.1861
Autor:
William L. Lowe, Robert Z. Florkiewicz, Brian N. Albrecht, Robert G. Spanheimer, Mark A. Yorek
Publikováno v:
Metabolism. 44:1038-1045
The underlying etiology of diabetic microvascular disease remains unknown. To examine the potential contribution of basic fibroblast growth factor (bFGF), which is an angiogenic factor, and insulin-like growth factor-I (IGF-I) to the development of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7498e06d65849f2d27fa4f92ce6a2ec5
https://doi.org/10.1016/0026-0495(95)90102-7
https://doi.org/10.1016/0026-0495(95)90102-7
Publikováno v:
Europe PubMed Central
In order to understand the regulation of basic fibroblast growth factor (bFGF) gene expression, we have cloned and characterized the human bFGF gene and its regulatory elements. Using restriction endonuclease digestion, we have mapped the entire gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772b14239ca9424f0176efd2934c6927
https://doi.org/10.3109/08977199109043913
https://doi.org/10.3109/08977199109043913
Publisher Summary Fibroblast growth factors isolated from many sources act to modify the growth of cell types of epithelial, neuroectodermal, and mesenchymal origin. Structurally, the FGF family encompasses the polypeptides encoded by 23 distinct gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ae767c68986ad9c02cce1443efa959
https://doi.org/10.1016/b978-012098652-1.50149-9
https://doi.org/10.1016/b978-012098652-1.50149-9
Human basic fibroblast growth factor (FGF-2) occurs in four isoforms: a low molecular weight (LMW FGF-2, 18 kDa) and three high molecular weight (HMW FGF-2, 22, 22.5, and 24 kDa) forms. LMW FGF-2 is primarily cytoplasmic and functions in an autocrine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33587c61e0fc3b0be555adb439404861
http://hdl.handle.net/2318/9504
http://hdl.handle.net/2318/9504
Publikováno v:
Nature. 348:344-346
Herpes simplex virus type-1 (HSV-1) is a ubiquitous pathogen that is associated with considerable morbidity in the general population. Although it is known that the virion uses a basic fibroblast growth factor (FGF) receptor to penetrate vascular cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3e5bc21ec2de74b7ecc38dbf8c1f0a
https://doi.org/10.1038/348344a0
https://doi.org/10.1038/348344a0