Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Robert Wodtke"'
Autor:
Robert Wodtke, Markus Laube, Sandra Hauser, Sebastian Meister, Friedrich-Alexander Ludwig, Steffen Fischer, Klaus Kopka, Jens Pietzsch, Reik Löser
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-25 (2024)
Abstract Background Transglutaminase 2 (TGase 2) is a multifunctional protein and has a prominent role in various (patho)physiological processes. In particular, its transamidase activity, which is rather latent under physiological conditions, gains i
Externí odkaz:
https://doaj.org/article/22eb1f3fd9ac49ebabcd4cbb268205c3
Autor:
Austin Craig, Jürgen Kogler, Markus Laube, Martin Ullrich, Cornelius K. Donat, Robert Wodtke, Klaus Kopka, Sven Stadlbauer
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2749 (2023)
Early detection and treatment of cancers can significantly increase patient prognosis and enhance the quality of life of affected patients. The emerging significance of the tumor microenvironment (TME) as a new frontier for cancer diagnosis and thera
Externí odkaz:
https://doaj.org/article/664a01d0f78c4972ad7e20ef2c2023c5
Autor:
Claudia Damaris Müller, Gloria Ruiz-Gómez, Sophie Cazzonelli, Stephanie Möller, Robert Wodtke, Reik Löser, Joanna Freyse, Jan-Niklas Dürig, Jörg Rademann, Ute Hempel, M. Teresa Pisabarro, Sarah Vogel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Transglutaminases (TGs) catalyze the covalent crosslinking of proteins via isopeptide bonds. The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial rol
Externí odkaz:
https://doaj.org/article/ec1ce90abb794cc0b3ccdc64ff3a478e
Autor:
Andreas Heerwig, Alfred Kick, Paul Sommerfeld, Sophia Eimermacher, Frederick Hartung, Markus Laube, Dietmar Fischer, Hans-Jürgen Pietzsch, Jens Pietzsch, Reik Löser, Michael Mertig, Markus Pietsch, Robert Wodtke
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1650 (2023)
In addition to the classic functions of proteins, such as acting as a biocatalyst or binding partner, the conformational states of proteins and their remodeling upon stimulation need to be considered. A prominent example of a protein that undergoes c
Externí odkaz:
https://doaj.org/article/f9e5b111a7044fb98321b290584126db
Autor:
Claudia Damaris Müller, Gloria Ruiz-Gómez, Sophie Cazzonelli, Stephanie Möller, Robert Wodtke, Reik Löser, Joanna Freyse, Jan-Niklas Dürig, Jörg Rademann, Ute Hempel, M. Teresa Pisabarro, Sarah Vogel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/3a52a3cf3ee5429eb426bbaf548003d3
Autor:
Sandy Lemm, Susanne Köhler, Robert Wodtke, Friedrich Jung, Jan-Heiner Küpper, Jens Pietzsch, Markus Laube
Publikováno v:
Cells, Vol 11, Iss 15, p 2447 (2022)
The characterization of novel radiotracers toward their metabolic stability is an essential part of their development. While in vitro methods such as liver microsome assays or ex vivo blood or tissue samples provide information on overall stability,
Externí odkaz:
https://doaj.org/article/7972334a5b5c4f9ab2b41f50fec351b0
Autor:
Julia Aepler, Johanna Wodtke, Robert Wodtke, Cathleen Haase-Kohn, Reik Löser, Jens Pietzsch, Sandra Hauser
Publikováno v:
Cells, Vol 11, Iss 8, p 1342 (2022)
Transglutaminase 2 (TG2) is a protein expressed in many tissues that exerts numerous, sometimes contradictory, intra- and extracellular functions, under both physiological and pathophysiological conditions. In the context of tumor progression, it has
Externí odkaz:
https://doaj.org/article/ea1a5c25e0194a22984ad05d55715ea2
Autor:
Sandra Hauser, Paul Sommerfeld, Johanna Wodtke, Christoph Hauser, Paul Schlitterlau, Jens Pietzsch, Reik Löser, Markus Pietsch, Robert Wodtke
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4475 (2022)
Transglutaminase 2 (TGase 2) is a multifunctional protein which is involved in various physiological and pathophysiological processes. The latter also include its participation in the development and progression of malignant neoplasms, which are ofte
Externí odkaz:
https://doaj.org/article/eeb528c97d29457faaf79a10066c3606
Publikováno v:
Molecules, Vol 26, Iss 22, p 7012 (2021)
Polyamines are highly attractive vectors for tumor targeting, particularly with regards to the development of radiolabeled probes for imaging by positron emission (PET) and single-photon emission computed tomography (SPECT). However, the synthesis of
Externí odkaz:
https://doaj.org/article/85729e00646a4a43974744b344116256
Autor:
Manuela Kuchar, Christin Neuber, Birgit Belter, Ralf Bergmann, Jens Lenk, Robert Wodtke, Torsten Kniess, Jörg Steinbach, Jens Pietzsch, Reik Löser
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Accumulating evidence suggests an unequivocal role of lysyl oxidases as key players of tumor progression and metastasis, which renders this enzyme family highly attractive for targeted non-invasive functional imaging of tumors. Considering their func
Externí odkaz:
https://doaj.org/article/9e550cd08dc145aeb4529e2acdfcff55