Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Robert Witte"'
Autor:
Dominik Olszewski, Fanny Georgi, Luca Murer, Vardan Andriasyan, Fabien Kuttler, Anthony Petkidis, Robert Witte, Artur Yakimovich, Lucy Fischer, Alina Rozanova, Yohei Yamauchi, Gerardo Turcatti, Urs F. Greber
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-12 (2022)
Measurement(s) transmission of virus • drug toxicity Technology Type(s) fluorescence microscopy Factor Type(s) virus genotype • cell line • incubation temperature • number of cells seeded/ seeding density • inoculation time • virus input
Externí odkaz:
https://doaj.org/article/7c70c488f62c453cb039023f3cc4d369
Autor:
Vardan Andriasyan, Artur Yakimovich, Anthony Petkidis, Fanny Georgi, Robert Witte, Daniel Puntener, Urs F. Greber
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102543- (2021)
Summary: Imaging across scales reveals disease mechanisms in organisms, tissues, and cells. Yet, particular infection phenotypes, such as virus-induced cell lysis, have remained difficult to study. Here, we developed imaging modalities and deep learn
Externí odkaz:
https://doaj.org/article/2642241825d0412abb91c66c05245b80
Publikováno v:
mSphere, Vol 3, Iss 6 (2018)
ABSTRACT Cytopathic effects (CPEs) are a hallmark of infections. CPEs are difficult to observe due to phototoxicity from classical light microscopy. We report distinct patterns of virus infections in live cells using digital holo-tomographic microsco
Externí odkaz:
https://doaj.org/article/d4895b3db8f344e0ae31a6d90c5e5692
Autor:
Artur Yakimovich, Vardan Andriasyan, Robert Witte, I-Hsuan Wang, Vibhu Prasad, Maarit Suomalainen, Urs F Greber
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138760 (2015)
Classical plaque assay measures the propagation of infectious agents across a monolayer of cells. It is dependent on cell lysis, and limited by user-specific settings and low throughput. Here, we developed Plaque2.0, a broadly applicable, fluorescenc
Externí odkaz:
https://doaj.org/article/80f0db5b2e8f41a69b8d7bef0286ffcb
Autor:
Robert Witte, Merle Arrowsmith, Anna Lamprecht, Fabian Schorr, Ivo Krummenacher, Holger Braunschweig
Publikováno v:
Chemistry – A European Journal. 29
A cyclic alkyl(amino)carbene (CAAC)‐stabilized dicoordinate aminoborylene is synthesized by the twofold reduction of a [(CAAC)BCl\(_{2}\)(TMP)] (TMP=2,6‐tetramethylpiperidyl) precursor. NMR‐spectroscopic, X‐ray crystallographic and computatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62db847893f027c4aeabd8b3b08b3ca0
https://doi.org/10.1002/chem.202203663
https://doi.org/10.1002/chem.202203663
Autor:
Holger Braunschweig, Felipe Fantuzzi, Alexander Matler, Merle Arrowsmith, Bernd Engels, Ivo Krummenacher, Anna Rempel, Tobias Bischof, Robert Witte, Eva Beck, Krzysztof Radacki, Maximilian Rang
Publikováno v:
Angewandte Chemie (International Ed. in English)
The one‐electron reduction of a cyclic (alkyl)(amino)carbene (CAAC)‐stabilized arylborylene carbonyl complex yields a dimeric borylketyl radical anion, resulting from an intramolecular aryl migration to the CO carbon atom. Computational analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be71183d9ca2ce81c620d33a4782b96
Autor:
Bernd Engels, Anna Rempel, Tobias Bischof, Alexander Matler, Eva Beck, Krzysztof Radacki, Robert Witte, Felipe Fantuzzi, Holger Braunschweig, Maximilian Rang, Merle Arrowsmith, Ivo Krummenacher
Bei der Einelektronenreduktion eines durch eine cyclisches (Alkyl)(amino)carben (CAAC) stabilisierten Arylborylen-Carbonylkomplexes erfolgt die Bildung eines dimeren Borylketyl-Radikalanions, bedingt durch eine intramolekulare Arylmigration zum CO Ko
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc2b919090fddd0bef85c5ac23b994b
https://doi.org/10.1002/ange.202014167
https://doi.org/10.1002/ange.202014167
A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus
Autor:
Urs F. Greber, Fabien Kuttler, Gerardo Turcatti, Artur Yakimovich, Robert Witte, Luca Murer, Fanny Georgi, Vardan Andriasyan
Publikováno v:
Scientific Data, Vol 7, Iss 1, Pp 1-12 (2020)
Scientific Data
Scientific Data
Human adenoviruses (HAdVs) are fatal to immuno-suppressed individuals, but no effective anti-HAdV therapy is available. Here, we present a novel image-based high-throughput screening (HTS) platform, which scores the full viral replication cycle from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471893b3a49d8cc948220b73c7879a87
https://doi.org/10.5167/uzh-189139
https://doi.org/10.5167/uzh-189139
Autor:
Robert Witte, Reinhard Kirschner
To prevent damage of the geomembrane by the gravel, a protective layer must be placed on the geomembrane. As a result of poor protective layers being used between geomembrane and drainage gravel, base sealing systems placed above the geomembrane usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b54a277ff246c4b28b33a16818986f9b
https://doi.org/10.1201/9781003062073-35
https://doi.org/10.1201/9781003062073-35
Autor:
Nicole Meili, Fanny Georgi, Luca Murer, Urs F. Greber, Robert Witte, Lisa Yu, Gerardo Turcatti, Artur Yakimovich, Melanie Grove, Vardan Andriasyan, Silvio Hemmi, Fabien Kuttler
Adenoviruses (AdVs) are prevalent and give rise to chronic and recurrent disease. The human AdV (HAdV) species B and C, such as HAdV-C2, C5 and B14, cause respiratory disease, and constitute a health threat for immuno-compromised individuals. HAdV-Cs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56f026ef9d467cf38d23c149f0a77e81
https://doi.org/10.1101/2020.05.15.098061
https://doi.org/10.1101/2020.05.15.098061