Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Robert Wirka"'
Autor:
Quanyi Zhao, Michael Dacre, Trieu Nguyen, Milos Pjanic, Boxiang Liu, Dharini Iyer, Paul Cheng, Robert Wirka, Juyong Brian Kim, Hunter B. Fraser, Thomas Quertermous
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Background To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create a catalog of genetic variants associated with
Externí odkaz:
https://doaj.org/article/5ffa8b35de57461e8faed264b5b9debe
Autor:
Samuel Röhl, MD, PhD, Urszula Rykaczewska, MSc, Till Seime, MSc, Bianca E. Suur, MSc, Maria Gonzalez Diez, PhD, Jesper R. Gådin, PhD, Anastasiia Gainullina, MSc, Alexey A. Sergushichev, PhD, Robert Wirka, MD, PhD, Mariette Lengquist, MSc, Malin Kronqvist, MSc, Otto Bergman, PhD, Jacob Odeberg, MD, PhD, Jan H.N. Lindeman, MD, PhD, Thomas Quertermous, MD, PhD, Anders Hamsten, MD, PhD, Per Eriksson, MSc, PhD, Ulf Hedin, MD, PhD, Anton Razuvaev, MD, PhD, Ljubica Perisic Matic, MSc, PhD
Publikováno v:
JVS - Vascular Science, Vol 1, Iss , Pp 13-27 (2020)
Objective: Endovascular interventions cause arterial injury and induce a healing response to restore vessel wall homeostasis. Complications of defective or excessive healing are common and result in increased morbidity and repeated interventions. Exp
Externí odkaz:
https://doaj.org/article/9d0b58197fa3444eb407e5862a0006ad
Autor:
Sampath Narayanan, Sofija Vuckovic, Robert Wirka, Mariette Lengquist, Thomas Quertermous, Ulf Hedin, Ljubica Matic
Publikováno v:
JVS - Vascular Science, Vol 3, Iss , Pp 413- (2022)
Externí odkaz:
https://doaj.org/article/cb0ec5b5acf0475f9f86f51bc559c879
Autor:
Quanyi Zhao, Robert Wirka, Trieu Nguyen, Manabu Nagao, Paul Cheng, Clint L. Miller, Juyong Brian Kim, Milos Pjanic, Thomas Quertermous
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-18 (2019)
Abstract Background Genome-wide association studies have identified over 160 loci that are associated with coronary artery disease. As with other complex human diseases, risk in coronary disease loci is determined primarily by altered expression of t
Externí odkaz:
https://doaj.org/article/3b459120b9da42e798da9ee5490cdb9e
Autor:
Dharini Iyer, Quanyi Zhao, Robert Wirka, Ameay Naravane, Trieu Nguyen, Boxiang Liu, Manabu Nagao, Paul Cheng, Clint L Miller, Juyong Brian Kim, Milos Pjanic, Thomas Quertermous
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007681 (2018)
Although numerous genetic loci have been associated with coronary artery disease (CAD) with genome wide association studies, efforts are needed to identify the causal genes in these loci and link them into fundamental signaling pathways. Recent studi
Externí odkaz:
https://doaj.org/article/99defefc362444aba60b5af133ec8f9c
Autor:
Roshni Roy Chowdhury, Jessica D’Addabbo, Xianxi Huang, Stefan Veizades, Koki Sasagawa, David M. Louis, Paul Cheng, Jan Sokol, Annie Jensen, Alexandria Tso, Vishnu Shankar, Ben Shogo Wendel, Isaac Bakerman, Grace Liang, Tiffany Koyano, Robyn Fong, Allison N. Nau, Herra Ahmad, Jayakrishnan Gopakumar, Robert Wirka, Andrew S. Lee, Jack Boyd, Y. Joseph Woo, Thomas Quertermous, Gunsagar Singh Gulati, Siddhartha Jaiswal, Yueh-Hsiu Chien, Charles Kwok Fai Chan, Mark M. Davis, Patricia K. Nguyen
Publikováno v:
Circ Res
Background:Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation‚ notable for the buildup of at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b963ff70f03fff08fe59f4a32f26d90e
https://doi.org/10.1161/circresaha.121.320090
https://doi.org/10.1161/circresaha.121.320090
Autor:
Sabrina Robichaud, Adil Rasheed, Antonietta Pietrangelo, Anne Doyoung Kim, Dominique M. Boucher, Christina Emerton, Viyashini Vijithakumar, Lara Gharibeh, Garrett Fairman, Esther Mak, My-Anh Nguyen, Michele Geoffrion, Robert Wirka, Katey J. Rayner, Mireille Ouimet
Publikováno v:
Circ Res
Rationale: Atherosclerosis is characterized by an accumulation of foam cells within the arterial wall, resulting from excess cholesterol uptake and buildup of cytosolic lipid droplets (LDs). Autophagy promotes LD clearance by freeing stored cholester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00aa5059b87fa789fffff2b6079635e
https://doi.org/10.1161/circresaha.121.320047
https://doi.org/10.1161/circresaha.121.320047
Autor:
Paul Cheng, Albert J Pedroza, Disha Sharma, Chad S Weldy, Trieu Nguyen, Alex R Dalal, Rohan Shad, Juyong B Kim, Michael P Fischbein, Robert Wirka, Thomas Quertermous
Publikováno v:
Circulation Research. 131
Background: Human vascular diseases are the worldwide leading causes of morbidity and mortality. Nearly all human vascular diseases have arterial segment-specific tropisms despite identical exposures to genetic and environmental risk factors. Underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::758f0e63c995210657d5716c8972ed27
https://doi.org/10.1161/res.131.suppl_1.p3006
https://doi.org/10.1161/res.131.suppl_1.p3006
Autor:
Trevor Henley, Julie Goudy, Marietta Easterling, Carrie Donley, Robert Wirka, Michael Bressan
Publikováno v:
Life Science Alliance. 6:e202201799
Cardiac pacemaker cells (CPCs) initiate the electric impulses that drive the rhythmic beating of the heart. CPCs reside in a heterogeneous, ECM-rich microenvironment termed the sinoatrial node (SAN). Surprisingly, little is known regarding the bioche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7851113af1949e4143c617d272f0c652
https://doi.org/10.26508/lsa.202201799
https://doi.org/10.26508/lsa.202201799
Autor:
Sabrina Robichaud, Adil Rasheed, Antonietta Pietrangelo, Anne Kim, Dominique Boucher, Chrissy Emerton, Viyashini Vijithakumar, Lara Gharibeh, Garrett Fairman, Esther Mak, My-anh Nguyen, Michele Geoffrion, Robert Wirka, Katey J Rayner, Mireille I Ouimet
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Atherosclerosis is characterized by a build-up of foam cells in the arterial wall, resulting from excess cholesterol uptake and accumulation of cytosolic lipid droplets (LDs). Autophagy has been shown to be atheroprotective in part by promoting the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::122d4f857f772e9ab70e43afa71da7be
https://doi.org/10.1161/atvb.42.suppl_1.207
https://doi.org/10.1161/atvb.42.suppl_1.207