Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Robert William Guthrie"'
Autor:
Louis M. Renzetti, Li Chen, Karen Rowan, Allen Sheffron, Tai-Nan Huang, Jian Ping Lou, Jefferson Wright Tilley, Kenneth G. Hull, Virginia Schwinge, Gerry Kaplan, Achyutharao Sidduri, Robert M. Campbell, Robert William Guthrie, Nicholas John Silvester Huby
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2475-2478
A systematic structure-activity relationship investigation of the lead compound 1 resulted the identification of several N-[(substituted alkyl)cycloalkanoyl]-4-[((2,6-dichlorophenyl)carbonyl)amino]-L-phenylalanine derivatives as potent VCAM/VLA-4 ant
Autor:
Karen Rowan, Jian Ping Lou, Tai-Nan Huang, Gerry Kaplan, Jefferson Wright Tilley, Achyutharao Sidduri, Robert M. Campbell, Virginia Schwinge, Robert William Guthrie, Louis M. Renzetti, Li Chen, Frank Mennona
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2479-2482
A series of N-benzoyl-4-[(2,6-dichlorobenzoyl)amino]-L-phenylalanine derivatives was prepared in order to optimize the substitution on the N-benzoyl moiety for VCAM/VLA-4 antagonist activity. Disubstitution in the 2- and 6-positions is favored and a
Autor:
Dorota Miklowski, Richard V. Trilles, Robert William Guthrie, Karen Rowan, Gerry Kaplan, Nicolas Huby, Barry A. Wolitzky, Jefferson Wright Tilley, Virginia Schwinge, Francis A. Mennona, Tai-Nan Huang, Li Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:729-733
A series of N-(N-benzylpyroglutamyl)-4-substituted-L-phenylalanine derivatives was prepared as VLA-4/VCAM antagonists. Analogues substituted by electron deficient benzoylamino groups bearing bulky ortho substituents had low-nM potency in an ELISA ass
Autor:
Gerry Kaplan, Ronald Andrew Lemahieu, Ru-Jen Han, S. D. Emerson, M. Carson, Robert William Guthrie, Li Chen, D. Biondi, T. Varnell, Jefferson Wright Tilley, Robert Palermo, Gordon D. Powers, Frank Mennona, David C. Fry, Grace Ju, Chao-Min Liu, Richard V. Trilles
Publikováno v:
Journal of the American Chemical Society. 119:7589-7590
Autor:
Mullin John Guilfoyle, Herman J. Crowley, Robert William Guthrie, L. C. Blaber, A. Faraone, B. Simko, Francis A. Mennona, R. W. Kierstead
Publikováno v:
Journal of Medicinal Chemistry. 26:1561-1569
A series of binary (aryloxy)propanolamines has been prepared and examined in vitro and in vivo for beta-adrenoreceptor blocking activity. These symmetrical compounds consist of two (S)-(phenyloxy)propanolamine pharmacophores coupled through alkylened
Autor:
Francis A. Mennona, Alfred Boris, Richard W. Kierstead, Robert William Guthrie, Mullin John Guilfoyle
Publikováno v:
Journal of Medicinal Chemistry. 16:257-262
Autor:
J. G. Mullin, L. C. Blaber, A. Faraone, B. Simko, Robert William Guthrie, F. A. Mennona, Richard W. Kierstead, Herman J. Crowley
Publikováno v:
Chemischer Informationsdienst. 15
Autor:
Alfred Boris, Robert William Guthrie, Francis A. Mennona, Richard W. Kierstead, Mullin John Guilfoyle
Publikováno v:
Journal of medicinal chemistry. 16(1)
Publikováno v:
Chemischer Informationsdienst. 4
Autor:
Alfred Boris, Richard W. Kierstead, Ronald Andrew Lemahieu, Robert William Guthrie, M. Carson
Publikováno v:
Journal of medicinal chemistry. 16(6)