Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Robert Webster"'
Autor:
Zaolan Liang, Xia Lin, Lihong Sun, Kimberly M. Edwards, Wenjun Song, Hailiang Sun, Yanmin Xie, Fangmei Lin, Shiman Ling, Tingting Liang, Biying Xiao, Jiaqi Wang, Min Li, Chin-Yu Leung, Huachen Zhu, Nisha Bhandari, Raghavan Varadarajan, Min Z. Levine, Malik Peiris, Robert Webster, Vijaykrishna Dhanasekaran, Nancy H. L. Leung, Benjamin J. Cowling, Richard J. Webby, Mariette Ducatez, Mark Zanin, Sook-San Wong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the 1957 pandemic, we investigate the reacti
Externí odkaz:
https://doaj.org/article/222177c2a96944b098415e28af694ad7
Autor:
Yaqin Bai, Hui Lei, Wenjun Song, Sang-Chul Shin, Jiaqi Wang, Biying Xiao, Zeynep A. Koçer, Min-Suk Song, Robert Webster, Richard J. Webby, Sook-San Wong, Mark Zanin
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
A diverse population of avian influenza A viruses (AIVs) are maintained in wild birds and ducks yet the zoonotic potential of AIVs in these environmental reservoirs and the host-virus interactions involved in mammalian infection are not well understo
Externí odkaz:
https://doaj.org/article/411295d31fac474f9a9f9f803fac9b85
Autor:
Hannah M. Jones, John Tolsma, Zhiwei Zhang, Paul Jasper, Haobin Luo, Gregory L. Weber, Katherine Wright, Joel Bard, Robert Bell, Dean Messing, Kerry Kelleher, Nicole Piche‐Nicholas, Robert Webster
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 9, Pp 534-541 (2020)
Monoclonal antibodies (mAbs) can be engineered to have “extended half‐life” and “catch and release” properties to improve target coverage. We have developed a mAb physiologically‐based pharmacokinetic model that describes intracellular tr
Externí odkaz:
https://doaj.org/article/cc8e779c5f0a47c995659f13bc259620
Autor:
Hannah M. Jones, Zhiwei Zhang, Paul Jasper, Haobin Luo, Lindsay B. Avery, Lindsay E. King, Hendrik Neubert, Hugh A. Barton, Alison M. Betts, Robert Webster
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 10, Pp 738-747 (2019)
Monoclonal antibody (mAb) pharmacokinetics (PK) have largely been predicted via allometric scaling with little consideration for cross‐species differences in neonatal Fc receptor (FcRn) affinity or clearance/distribution mechanisms. To address this
Externí odkaz:
https://doaj.org/article/c58bb5351c0144759f98b87e000c61f8
Autor:
Georgi I. Kapitanov, Jeffrey R. Chabot, Jatin Narula, Mahua Roy, Hendrik Neubert, Joe Palandra, Vahid Farrokhi, Jay S. Johnson, Robert Webster, Hannah M. Jones
Publikováno v:
Frontiers in Bioinformatics, Vol 1 (2021)
Quantitative modeling is increasingly utilized in the drug discovery and development process, from the initial stages of target selection, through clinical studies. The modeling can provide guidance on three major questions–is this the right target
Externí odkaz:
https://doaj.org/article/f1c2678042d0412ca6b18e6b806678c5
Autor:
Rebecca Poulson, Deborah Carter, Shelley Beville, Lawrence Niles, Amanda Dey, Clive Minton, Pamela McKenzie, Scott Krauss, Richard Webby, Robert Webster, David E. Stallknecht
Publikováno v:
Viruses, Vol 12, Iss 11, p 1205 (2020)
Each May for over three decades, avian influenza A viruses (IAVs) have been isolated from shorebirds and gulls (order Charadriiformes) at Delaware Bay (DE Bay), USA, which is a critical stopover site for shorebirds on their spring migration to arctic
Externí odkaz:
https://doaj.org/article/ea26c8699ed14528a4de31a3c82cb41c
Publikováno v:
California Agriculture, Vol 68, Iss 4, Pp 134-141 (2014)
An outbreak of Pierce's disease of grapevine in the Temecula Valley in the late 1990s was one in a decades-long series of sporadic appearances of this infection in California. However, the new outbreak was qualitatively different because of the rap
Externí odkaz:
https://doaj.org/article/82d332c4c35a4ea79371937b71618187
Publikováno v:
California Agriculture, Vol 68, Iss 4, Pp 138-139 (2014)
Externí odkaz:
https://doaj.org/article/64f6c7fcb1684a38823d2f4eb38a71c2
Autor:
Rebecca M Turner, Myfanwy Lloyd-Jones, Dilly O C Anumba, Gordon C S Smith, David J Spiegelhalter, Hazel Squires, John W Stevens, Michael J Sweeting, Stanislaw J Urbaniak, Robert Webster, Simon G Thompson
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30711 (2012)
To estimate the effectiveness of routine antenatal anti-D prophylaxis for preventing sensitisation in pregnant Rhesus negative women, and to explore whether this depends on the treatment regimen adopted.Ten studies identified in a previous systematic
Externí odkaz:
https://doaj.org/article/01723b1a391c4b6ab68cc97a942e516c
H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load
Autor:
Adrianus C. M. Boon, David Finkelstein, Ming Zheng, Guochun Liao, John Allard, Klaus Klumpp, Robert Webster, Gary Peltz, Richard J. Webby
Publikováno v:
mBio, Vol 2, Iss 5 (2011)
ABSTRACT The genotype of the host is one of several factors involved in the pathogenesis of an infectious disease and may be a key parameter in the epidemiology of highly pathogenic H5N1 influenza virus infection in humans. Gene polymorphisms may aff
Externí odkaz:
https://doaj.org/article/3a9487f42a7647bf9dbb2acaf2b7d349