Výsledky vyhledávání - "Robert W. Tilghman"

Akademický článek

Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis.

Autor: Robert W Tilghman, Edik M Blais, Catharine R Cowan, Nicholas E Sherman, Pablo R Grigera, Erin D Jeffery, Jay W Fox, Brett R Blackman, Daniel J Tschumperlin, Jason A Papin, J Thomas Parsons

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37231 (2012)

Tumor cells in vivo encounter diverse types of microenvironments both at the site of the primary tumor and at sites of distant metastases. Understanding how the various mechanical properties of these microenvironments affect the biology of tumor cell

Externí odkaz: https://doaj.org/article/673a17e071dc46ae9e1ff2e9ef483c46

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Akademický článek

FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing.

Autor: Katherine A Owen, Michelle Y Abshire, Robert W Tilghman, James E Casanova, Amy H Bouton

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23123 (2011)

Following damage to the intestinal epithelium, restoration of epithelial barrier integrity is triggered by a robust proliferative response. In other tissues, focal adhesion kinase (FAK) regulates many of the cellular processes that are critical for e

Externí odkaz: https://doaj.org/article/32a3398e065841ca9677d4d18c14e8b2

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Akademický článek

Matrix rigidity regulates cancer cell growth and cellular phenotype.

Autor: Robert W Tilghman, Catharine R Cowan, Justin D Mih, Yulia Koryakina, Daniel Gioeli, Jill K Slack-Davis, Brett R Blackman, Daniel J Tschumperlin, J Thomas Parsons

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12905 (2010)

The mechanical properties of the extracellular matrix have an important role in cell growth and differentiation. However, it is unclear as to what extent cancer cells respond to changes in the mechanical properties (rigidity/stiffness) of the microen

Externí odkaz: https://doaj.org/article/4a8c02aa9e524f6f874edcd48cd9d95d

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FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts

Autor: Karen H. Martin, Tomáš Vomastek, Jayashree Banerjee, J. Thomas Parsons, Robert W. Tilghman, Philip B. Wedegaertner, Marcin P. Iwanicki

Publikováno v: Journal of Cell Science. 121:895-905

A key step in cell migration is the dynamic formation and disassembly of adhesions at the front and the concomitant movement and release of adhesions in the rear of the cell. Fibroblasts maintained in the absence of serum have stable adhesions within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69d13df8ab533a75f10a52913526d91
https://doi.org/10.1242/jcs.020941

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Focal adhesion kinase as a regulator of cell tension in the progression of cancer

Autor: Robert W. Tilghman, J. Thomas Parsons

Publikováno v: Seminars in Cancer Biology. 18:45-52

Growing evidence indicates that critical steps in cancer progression such as cell adhesion, migration, and cell cycle progression are regulated by the composition and organization of the microenvironment. The adhesion of cancer cells to components of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970b7ba40e3109a66f9a20465286c09e
https://doi.org/10.1016/j.semcancer.2007.08.002

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