Výsledky vyhledávání - "Robert W. McNutt"

Binding of [3H](+)-BW373U86 to δ-opioid receptors in rat brain membranes

Autor: Edward F. Patz, Kwen-Jen Chang, John A. Hill, Michael J. Campa, Robert W. McNutt

Publikováno v: European Journal of Pharmacology. 310:263-267

A tritiated form of the non-peptide delta-opioid receptor agonist (+)-BW373U86 ((+)-4-((alpha-R)-alpha-((2S,5R)-4-allyl-2, 5-dimethyl-l-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide) was synthesized and its binding characteristics studied. [3H](

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e6466685993686de44037794d69947
https://doi.org/10.1016/0014-2999(96)00483-9

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Synthesis, stereochemistry, and opioid receptor binding activity of heterocyclic analogues of BW373U86

Autor: Kwen-Jen Chang, G. Evan Boswell, Bubacz Dulce Garrido, Robert W. McNutt, Ann O. Davis

Publikováno v: Journal of Heterocyclic Chemistry. 32:1801-1818

The synthesis of a series of heterocyclic analogues of (±)-4-((αR*)-α-((2S*,5R*)-4-allyl-2,5-dimethyl-1-piperazmyl)-3-hydroxybenzyl)-N,N-diethylbenzarrude (BW373U86) for screening against opioid receptors is described. The intermediate α-heterocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37737a7d9edce5e0290d76e1c0a9659e
https://doi.org/10.1002/jhet.5570320622

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An efficient synthesis of the benzhydrylpiperazine delta opioid agonist (+)-BW373U86

Autor: Robert W. McNutt, Michael J. Bishop

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:1311-1314

A diastereoselective version of Katritzky's method for tertiary amine formation provides an efficient route to the highly selective, non-peptidal, delta opioid agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d53d7b1e6955322b9fe4aab273cf6cbf
https://doi.org/10.1016/0960-894x(95)00213-d

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Opioid Peptide Receptor Studies 2. [3H]SNC-121, a Novel, Selective, and High-Affinity Ligand for Opioid Delta Receptors

Autor: Subramaniam Ananthan, Frank Porreca, Qing Ni, Silvia N. Calderon, Kenner C. Rice, John S. Partilla, Robert W. McNutt, Craig M. Bertha, Heng Xu, Richard B. Rothman

Publikováno v: Analgesia. 1:185-193

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4621a223f8302b45931acd89fb946e1a
https://doi.org/10.3727/107156995819564239

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Probes for Narcotic Receptor Mediated Phenomena. 19. Synthesis of (+)-4-[(.alpha.R)-.alpha.-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide .delta. Opioid Receptor Agonist

Autor: Kenner C. Rice, Richard B. Rothman, L.E. Smith, Peg Davis, Frank Porreca, Heng Xu, Silvia N. Calderon, Edward J. Bilsky, Robert W. McNutt, Judith L. Flippen-Anderson

Publikováno v: Journal of Medicinal Chemistry. 37:2125-2128

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c845acebaccb4a628193958a338272e9
https://doi.org/10.1021/jm00040a002

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Binding of BW 373U86, a non-peptidic δ opioid receptor agonist, is not regulated by guanine nucleotides and sodium

Autor: Frank Porreca, Lei Fang, Robert W. McNutt, Henry I. Yamamura, Géza Tóth, K D Wild, Ana Borsodi, Kwen Jen Chang

Publikováno v: European Journal of Pharmacology: Molecular Pharmacology. 246:289-292

BW 373U86 is a novel, non-peptidic δ-opioid receptor ligand with agonist properties in mouse brain and in the mouse isolated vas deferens. The sensitivity of BW 373U86, and of the peptidic δ-opioid agonists [ d -Pen 2 , D-Pen 5 ]enkephalin (DPDPE)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cc49efb5ec33a797ad1dd64461d992
https://doi.org/10.1016/0922-4106(93)90044-a

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