Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Robert W. McGarrah"'
Autor:
Elizabeth A. Kobe, Aarti Thakkar, Sarina Matai, Esra Akkaya, Neha J. Pagidipati, Robert W. McGarrah, Gerald S. Bloomfield, Nishant P. Shah
Publikováno v:
American Journal of Preventive Cardiology, Vol 20, Iss , Pp 100888- (2024)
Effective antiretroviral therapy (ART) is now nearly ubiquitous. However, the survival benefits conferred with ART contribute to an aging human immunodeficiency virus (HIV) population and increased risk of chronic diseases, like atherosclerotic cardi
Externí odkaz:
https://doaj.org/article/abd1b9361a1a4324bfd0ab263ef5ebed
Autor:
Jessica A. Regan, Robert J. Mentz, Maggie Nguyen, Jennifer B. Green, Lauren K. Truby, Olga Ilkayeva, Christopher B. Newgard, John B. Buse, Harald Sourij, C. David Sjöström, Naveed Sattar, Robert W. McGarrah, Yinggan Zheng, Darren K. McGuire, Eberhard Standl, Paul Armstrong, Eric D. Peterson, Adrian F. Hernandez, Rury R. Holman, Svati H. Shah
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Metabolic mechanisms underlying the heterogeneity of major adverse cardiovascular (CV) event (MACE) risk in individuals with type 2 diabetes mellitus (T2D) remain unclear. We hypothesized that circulating metabolites reflecting mitochondrial dysfunct
Externí odkaz:
https://doaj.org/article/3f275be854a44c41b0338f5a6d3451b9
Autor:
Julia Karády, Maros Ferencik, Thomas Mayrhofer, Nandini M. Meyersohn, Daniel O. Bittner, Pedro V. Staziaki, Balint Szilveszter, Travis R. Hallett, Michael T. Lu, Stefan B. Puchner, Tracey G. Simon, Borek Foldyna, Geoffrey S. Ginsburg, Robert W. McGarrah, Deepak Voora, Svati H. Shah, Pamela S. Douglas, Udo Hoffmann, Kathleen E. Corey
Publikováno v:
Hepatology Communications, Vol 6, Iss 12, Pp 3406-3420 (2022)
Abstract Cardiovascular disease (CVD) is the leading cause of mortality in adults with hepatic steatosis (HS). However, risk factors for CVD in HS are unknown. We aimed to identify factors associated with coronary artery disease (CAD) and incident ma
Externí odkaz:
https://doaj.org/article/a24857b7a81141318f46482d688d76b6
Autor:
Joseph B. Lerman, Stephanie N. Giamberardino, Adrian F. Hernandez, G. Michael Felker, Svati H. Shah, Robert W. McGarrah
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Heart failure with reduced ejection fraction (HFrEF) is increasingly treated with medications for type 2 diabetes mellitus (T2DM). Whether metabolic derangements in HFrEF and T2DM are associated with differential outcomes remains unclear. Th
Externí odkaz:
https://doaj.org/article/295fb7db955a4b4fac37fd8e0e460f53
Autor:
Robert W. McGarrah, Maros Ferencik, Stephanie N. Giamberardino, Udo Hoffmann, Borek Foldyna, Julia Karady, Geoffrey S. Ginsburg, William E. Kraus, Pamela S. Douglas, Svati H. Shah
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 1 (2023)
BACKGROUND More than half of major adverse cardiovascular events (MACE) occur in the absence of obstructive coronary artery disease and are often attributed to the rupture of high‐risk coronary atherosclerotic plaque (HRP). Blood‐based biomarkers
Externí odkaz:
https://doaj.org/article/2fbbbca0406f44a5a75a6fcc5d5be5ae
Autor:
Lauren K. Truby, Jessica A. Regan, Stephanie N. Giamberardino, Olga Ilkayeva, James Bain, Christopher B. Newgard, Christopher M. O’Connor, G. Michael Felker, William E. Kraus, Robert W. McGarrah, Svati H. Shah
Publikováno v:
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-10 (2021)
Abstract Background Whether differences in circulating long chain acylcarnitines (LCAC) are seen in heart failure (HF) patients with and without diabetes mellitus (DM), and whether these biomarkers report on exercise capacity and clinical outcomes, r
Externí odkaz:
https://doaj.org/article/8e4ae4722022434d889491348a64d28b
Autor:
Thomas Grenier-Larouche, Lydia Coulter Kwee, Yann Deleye, Paola Leon-Mimila, Jacquelyn M. Walejko, Robert W. McGarrah, Simon Marceau, Sylvain Trahan, Christine Racine, André C. Carpentier, Aldons J. Lusis, Olga Ilkayeva, Marie-Claude Vohl, Adriana Huertas-Vazquez, André Tchernof, Svati H. Shah, Christopher B. Newgard, Phillip J. White
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Hepatic de novo lipogenesis is influenced by the branched-chain α-keto acid dehydrogenase (BCKDH) kinase (BCKDK). Here, we aimed to determine whether circulating levels of the immediate substrates of BCKDH, the branched-chain α-keto acids (BCKAs),
Externí odkaz:
https://doaj.org/article/6137ea5ab08f4f1cb6e623ab02150e6f
Autor:
Anthony E. Peters, Ambarish Pandey, Colby Ayers, Kara Wegermann, Robert W. McGarrah, Justin L. Grodin, Manal F. Abdelmalek, Tarek Bekfani, Vanessa Blumer, Anna Mae Diehl, Cynthia A. Moylan, Marat Fudim
Publikováno v:
ESC Heart Failure, Vol 8, Iss 2, Pp 842-848 (2021)
Abstract Aims Non‐alcoholic fatty liver disease leads to progressive liver fibrosis and appears to be a frequent co‐morbid disease in heart failure with preserved ejection fraction (HFpEF). It is well known that liver fibrosis severity predicts f
Externí odkaz:
https://doaj.org/article/e67e539858ad4fc2b3ae455e47041b95
Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
Autor:
Jacquelyn M. Walejko, Bridgette A. Christopher, Scott B. Crown, Guo-Fang Zhang, Adrian Pickar-Oliver, Takeshi Yoneshiro, Matthew W. Foster, Stephani Page, Stephan van Vliet, Olga Ilkayeva, Michael J. Muehlbauer, Matthew W. Carson, Joseph T. Brozinick, Craig D. Hammond, Ruth E. Gimeno, M. Arthur Moseley, Shingo Kajimura, Charles A. Gersbach, Christopher B. Newgard, Phillip J. White, Robert W. McGarrah
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Systemic modulation of branched-chain keto acid (BCKA) metabolism alters cardiac health. Here, the authors define the major fates of BCKA in the heart and demonstrate that acute exposure to BCKA levels found in obesity activates cardiac protein synth
Externí odkaz:
https://doaj.org/article/13e6e6480fe7436f81d6416509424af3
Autor:
Marat Fudim, Lin Zhong, Kershaw V. Patel, Rohan Khera, Manal F. Abdelmalek, Anna Mae Diehl, Robert W. McGarrah, Jeroen Molinger, Cynthia A. Moylan, Vishal N. Rao, Kara Wegermann, Ian J. Neeland, Ethan A. Halm, Sandeep R. Das, Ambarish Pandey
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
Background Nonalcoholic fatty liver disease (NAFLD) and heart failure (HF) are increasing in prevalence. The independent association between NAFLD and downstream risk of HF and HF subtypes (HF with preserved ejection fraction and HF with reduced ejec
Externí odkaz:
https://doaj.org/article/0348b254322045d6b98f37ff6e5d05af