Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Robert W. Marquis"'
Autor:
Yves Dondelinger, Wim Declercq, Sylvie Montessuit, Ria Roelandt, Amanda Goncalves, Inge Bruggeman, Paco Hulpiau, Kathrin Weber, Clark A. Sehon, Robert W. Marquis, John Bertin, Peter J. Gough, Savvas Savvides, Jean-Claude Martinou, Mathieu J.M. Bertrand, Peter Vandenabeele
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 971-981 (2014)
Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood. Here, we demonstrate that the full four-helical bundle d
Externí odkaz:
https://doaj.org/article/861d16d1f33d45d7a36b240ef8000808
Autor:
Bartholomew J. Votta, Michael Reilly, Linda N. Casillas, Robert W. Marquis, Rakesh Nagilla, Mukesh K. Mahajan, Demartino Michael P, John Bertin, Helen H. Sun, Elizabeth J. Rivera, Pamela A. Haile
Publikováno v:
Journal of Pharmaceutical Sciences. 109:3160-3171
Receptor Interacting Protein 2 (RIP2) kinase inhibitors have been reported for therapeutic opportunities in inflammatory bowel diseases such as Ulcerative Colitis and Crohn's disease. During lead optimization, team identified 4-aminoquinoline series
Autor:
Ami S. Lakdawala, Shawn P. Williams, Demartino Michael P, Ramanjulu Joshi M, Yunfeng Lan, Robert W. Marquis
Publikováno v:
ACS Med Chem Lett
[Image: see text] The pregnane X receptor (PXR) regulates expression of proteins responsible for all three phases required for the detoxification mechanism, which include CYP450 enzymes, phase II enzymes, and multidrug efflux pumps. Therefore, PXR is
Autor:
Pamela A. Haile, Linda N. Casillas, Bartholomew J. Votta, Gren Z. Wang, Adam K. Charnley, Xiaoyang Dong, Michael J. Bury, Joseph J. Romano, John F. Mehlmann, Bryan W. King, Karl F. Erhard, Charles R. Hanning, David B. Lipshutz, Biva M. Desai, Carol A. Capriotti, Michelle C. Schaeffer, Scott B. Berger, Mukesh K. Mahajan, Michael A. Reilly, Rakesh Nagilla, Elizabeth J. Rivera, Helen H. Sun, John K. Kenna, Allison M. Beal, Michael T. Ouellette, Mike Kelly, Gillian Stemp, Máire A. Convery, Anna Vossenkämper, Thomas T. MacDonald, Peter J. Gough, John Bertin, Robert W. Marquis
Publikováno v:
Journal of Medicinal Chemistry. 62:6482-6494
Autor:
Stéphane Sautet, Emilie Jigorel, Nicolas Faucher, Jamel Meslamani, Lara Kathryn Leister, Pascal Grondin, Julie A. Cox, Bryan W. King, Pamela Nassau, Gemma Victoria White, Brad J. Geddes, Alain Claude-Marie Daugan, Helen H. Sun, Michael T. Ouellette, Pauline Lamoureux, Elizabeth J. Rivera, Scott B. Berger, James H. Thorpe, Philip A. Harris, J. Mosley, Susan E. Hutchinson, Frédéric Donche, John Bertin, Sandra J. Hoffman, Natalie Wellaway, Patrick M. Eidam, Paris Ward, Florent Potvain, Clark A. Sehon, Sebastien Andre Campos, Robert W. Marquis, Peter J. Gough, Mukesh K. Mahajan, Veronique Beneton, Jae U. Jeong, Michelle C. Schaeffer, John D. Lich, Allison M. Beal, Rakesh Nagilla, James Michael Woolven, Bonnie L. Hoffman, Anderson Niall Andrew, Marie-Hélène Fouchet, Deepak Bandyopadhyay, Carol A. Capriotti, Rachel D. Totoritis, Joshua N. Finger, Kishore K. Pasikanti, David D. Wisnoski, Sze-Ling Ng, Nino Campobasso, Nicolas George, Michael Reilly
Publikováno v:
Journal of Medicinal Chemistry. 62:5096-5110
RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently, RIP1 kinase inhibitors have advanced into early clinical
Autor:
David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Pamela A Haile, Xin Zeng, Monica N Montoute, Derek D Poore, Hu Li, Zining Wu, Patrick M Eidam, John G Emery, Robert W Marquis, Peter J Gough, John Bertin
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96737 (2014)
NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-interacting protein (RIP)-2 kinase and initiates a
Externí odkaz:
https://doaj.org/article/d8966b29a270430a972aa590bfa33f4f
Autor:
David J Rickard, Clark A Sehon, Viera Kasparcova, Lorena A Kallal, Xin Zeng, Monica N Montoute, Tushar Chordia, Derek D Poore, Hu Li, Zining Wu, Patrick M Eidam, Pamela A Haile, Jong Yu, John G Emery, Robert W Marquis, Peter J Gough, John Bertin
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69619 (2013)
NOD2 is an intracellular pattern recognition receptor that assembles with receptor-interacting protein (RIP)-2 kinase in response to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby inducing signals leading to the
Externí odkaz:
https://doaj.org/article/5e593a2a329d48da9774642aa0357266
Autor:
Xiaoyang Dong, Anna Vossenkämper, Attiq Rahman, Viera Kasparcova, Robert Singhaus, Joshua N. Finger, Bryan W. King, Patrick M. Eidam, Michael Reilly, David D. Wisnoski, Scott B. Berger, John D. Lich, James Kang, Michael T. Ouellette, Lauren Dare, Philip A. Harris, Julie A. Cox, Nathan A. Miller, John Bertin, Michelle C. Schaeffer, Deepak Bandyopadhyay, Daohua Zhang, Alan R. Rendina, Clark A. Sehon, Sandra J. Hoffman, Peter J. Gough, Rachel D. Totoritis, Thomas T. MacDonald, Yunfeng Lan, Paris Ward, Barbara A. Swift, Robert W. Marquis, Lara Kathryn Leister, Rakesh Nagilla, Elizabeth J. Rivera, Helen H. Sun, Carol A. Capriotti, Nino Campobasso, Ruth Lehr, Christina S. Pao, Jae U. Jeong
Publikováno v:
Journal of Medicinal Chemistry. 60:1247-1261
RIP1 regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. Small-molecule inhibitors of RIP1 kinase that are suitable for advancement
Autor:
Arthur Shu, Yiqian Lian, Huijie Li, Curt Dale Haffner, Terry Vincent Hughes, Ami S. Lakdawala, Julie A. Cox, Pamela A. Haile, Constantine Kreatsoulas, Beth Anne Knapp-Reed, Lisa M. Shewchuk, David B. Lipshutz, John F. Mehlmann, Michael T. Ouellette, Christopher J Aquino, Mark Elban, Nicole Cathleen Goodwin, Huiqiang Zhou, Adam Kenneth Charnley, Bartholomew J. Votta, Robert W. Marquis, Joseph J. Romano, Linda N. Casillas, Peter J. Gough, Máire A. Convery, John Bertin
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein we report the discovery of pyrazolocarboxamides as novel, potent, and kinase selective inhibitors of receptor interacting protein 2 kinase (RIP2). Fragment based screening and design principles led to the identification of th
Autor:
Joshua N. Finger, Michael T. Ouellette, Helen H. Sun, Robert W. Marquis, Viera Kasparcova, James H. Thorpe, Scott B. Berger, Philip A. Harris, Rakesh Nagilla, George Miller, Anirudh Chirala, James Kang, Elizabeth J. Rivera, John Bertin, Peter J. Gough, Mukesh K. Mahajan, Daohua Zhang, John D. Lich, Julie A. Cox, Wei Wang, Lara Kathryn Leister, Jill M. Marinis, Rachel D. Totoritis, Patrick M. Eidam, Michael Reilly, Jae U. Jeong, Dongling Wu, Alan R. Rendina
Publikováno v:
ACS Medicinal Chemistry Letters
'ACS Medicinal Chemistry Letters ', vol: 10, pages: 857-862 (2019)
'ACS Medicinal Chemistry Letters ', vol: 10, pages: 857-862 (2019)
RIP1 regulates cell death and inflammation and is believed to play an important role in contributing to a variety of human pathologies, including immune-mediated inflammatory diseases and cancer. While small-molecule inhibitors of RIP1 kinase have be