Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Robert W. Lim"'
Autor:
Shivendra D. Shukla, Jacob D. Franke, Xuanyou Liu, Ronald J. Korthuis, Ricardo J. Restrepo, David A. Ford, Robert W. Lim, Annayya R. Aroor
Publikováno v:
J Pharmacol Exp Ther
Binge alcohol consumption is a health problem, but differences between the sexes remain poorly defined. We have examined the in vivo effects of three acute, repeat binge alcohol administration on the liver in male and female rats. Sprague-Dawley rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41502570549f64cad3a91fd6d823532
https://europepmc.org/articles/PMC6695503/
https://europepmc.org/articles/PMC6695503/
Publikováno v:
Alcohol and Alcoholism. 47:233-239
Aims: The aim of this study was to determine the effect of chronic ethanol feeding on acetylation of histone H3 at lysine 9 (H3-Lys9) at promoter and coding regions of genes for class I alcohol dehydrogenase (ADH I), inducible nitric oxide synthase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0539d85ba5d5b5177ec9514135b16f53
https://doi.org/10.1093/alcalc/ags004
https://doi.org/10.1093/alcalc/ags004
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 354(1)
Ethanol and its major metabolite acetate both induced histone H3 acetylation in primary culture of rat hepatocytes. The acetylation by ethanol was dependent on the reactive oxygen species and mitogen-activated protein kinase pathway, whereas that by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead116f461e4749df49ab0831c725ceb
https://pubmed.ncbi.nlm.nih.gov/25886906
https://pubmed.ncbi.nlm.nih.gov/25886906
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 289:G1124-G1136
Ethanol treatment increases gene expression in the liver through mechanisms that are not clearly understood. Histone acetylation has been shown to induce transcriptional activation. We have investigated the characteristics and mechanisms of ethanol-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cacbc035b164df898e5c655fce6bf1d
https://doi.org/10.1152/ajpgi.00091.2005
https://doi.org/10.1152/ajpgi.00091.2005
Publikováno v:
Archives of Biochemistry and Biophysics. 390:42-50
We have constructed a strain that overproduces ribonuclease I of Escherichia coli and we have purified large quantities of the enzyme. Data from fluorescence, CD, and DSC measurements showed that it was a very stable protein. The conformation energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2384312d5f627a0272d21f578b91828
https://doi.org/10.1006/abbi.2001.2359
https://doi.org/10.1006/abbi.2001.2359
Autor:
Shivendra D, Shukla, Robert W, Lim
Publikováno v:
Alcohol Research : Current Reviews
The widening web of epigenetic regulatory mechanisms also encompasses ethanol-induced changes in the gastrointestinal (GI)–hepatic system. In the past few years, increasing evidence has firmly established that alcohol modifies several epigenetic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b51fa8ec84b32391e3322a6de1e178a6
https://pubmed.ncbi.nlm.nih.gov/24313164
https://pubmed.ncbi.nlm.nih.gov/24313164
Autor:
Robert W. Lim, Kaichuan Yeh
Publikováno v:
Gene. 254:163-171
Overexpression of the helix-loop-helix motif-containing transcription inhibitor Id3 has been shown to repress muscle-specific gene expression. Consistent with its putative negative regulatory role in the myogenic process, Id3 is highly expressed in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150fe96b7eaca9e6d28130dd7b967b6c
https://doi.org/10.1016/s0378-1119(00)00274-2
https://doi.org/10.1016/s0378-1119(00)00274-2
Modulation of muscle creatine kinase promoter activity by the inducible orphan nuclear receptor TIS1
Autor:
Wan-Lin Yang, Robert W. Lim
Publikováno v:
Biochemical Journal. 321:281-287
TIS1, an inducible orphan nuclear receptor, was originally isolated as a tumour-promoter-inducible gene in mouse 3T3 cells and later shown to be induced by growth factors and other extracellular stimuli. We show here that TIS1 mRNA was expressed in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30711b832afb3a5767f99e2fa56d5fa2
https://doi.org/10.1042/bj3210281
https://doi.org/10.1042/bj3210281
Autor:
Binbin Chen, Robert W. Lim
Publikováno v:
Journal of Biological Chemistry. 272:2459-2463
We have used an interaction cloning strategy to identify an inhibitory isoform of the ITF-2 transcription factor, ITF-2b, that interacts with the transcriptional inhibitor Id3/HLH462. The interaction was confirmed in vitro, and inside intact myogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e51f611fda1f1aed5a73b17c72b5f3e
https://doi.org/10.1074/jbc.272.4.2459
https://doi.org/10.1074/jbc.272.4.2459
Autor:
Monica M. Montano, Robert W. Lim
Publikováno v:
Endocrine Research. 23:37-57
We examined the effect of glucocorticoids on the proliferation and differentiation of skeletal muscle cells using the C2C12 cell line. We found that treatment with glucocorticoids enhanced muscle cell differentiation but had only minor effects on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3d649fe5a26a7156066d816793547f
https://doi.org/10.1080/07435809709031841
https://doi.org/10.1080/07435809709031841