Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Robert W. Keane"'
Autor:
Ruby R. Taylor, Robert W. Keane, Begoña Guardiola, Sofía López-Lage, Lesmes Moratinos, W. Dalton Dietrich, Jon Perez-Barcena, Juan Pablo de Rivero Vaccari
Publikováno v:
Cells, Vol 13, Iss 16, p 1370 (2024)
Aneurysmal subarachnoid hemorrhage (aSAH) is caused by abnormal blood vessel dilation and subsequent rupture, resulting in blood pooling in the subarachnoid space. This neurological insult results in the activation of the inflammasome, a multiprotein
Externí odkaz:
https://doaj.org/article/229e4030c7824d5799ff29c0ee3a6693
Autor:
Brianna Cyr, Erika D. L. R. M. Cabrera Ranaldi, Roey Hadad, W. Dalton Dietrich, Robert W. Keane, Juan Pablo de Rivero Vaccari
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionAlzheimer’s disease (AD) is an inflammatory neurodegenerative disease characterized by memory loss and cognitive impairment that worsens over time. AD is associated with many comorbidities, including cardiovascular disease that are asso
Externí odkaz:
https://doaj.org/article/527f6767b3044ad1bf074f24e9de795d
Autor:
Brianna Cyr, Rosie Curiel Cid, David Loewenstein, Regina T. Vontell, W. Dalton Dietrich, Robert W. Keane, Juan Pablo de Rivero Vaccari
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7758 (2024)
Dementia is a group of symptoms including memory loss, language difficulties, and other types of cognitive and functional impairments that affects 57 million people worldwide, with the incidence expected to double by 2040. Therefore, there is an unme
Externí odkaz:
https://doaj.org/article/bd0319cd8e61414ea2871f38e20c35ef
Autor:
Regina T. Vontell, Ryan Gober, Julian Dallmeier, Daniel Brzostowicki, Ayled Barreda, Kaj Blennow, Henrik Zetterberg, Hlin Kvartsberg, Sakir Humayun Gultekin, Juan Pablo deRivero Vaccari, Helen M. Bramlett, W. Dalton Dietrich, Robert W. Keane, David A. Davis, Tatjana Rundek, Xiaoyan Sun
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION Neurogranin (Ng) is considered a biomarker for synaptic dysfunction in Alzheimer's disease (AD). In contrast, the inflammasome complex has been shown to exacerbate AD pathology. METHODS We investigated the protein expression, mo
Externí odkaz:
https://doaj.org/article/b004ddac02d747e7a1752bb243a63c79
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionOne of the main characteristics of COVID-19 is an exacerbated inflammatory response that results in cardiometabolic complications and dysfunction in the nervous system. Moreover, these complications may extend beyond the period of active
Externí odkaz:
https://doaj.org/article/150aa13bd6a14a4bb6d73c325470c111
Autor:
Robert W. Keane, Roey Hadad, Xavier O. Scott, Erika d. l. R. M. Cabrera Ranaldi, Jon Pérez-Bárcena, Juan Pablo de Rivero Vaccari
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1382 (2023)
Traumatic brain injury (TBI) affects not only the brain but also peripheral organs like the heart and the lungs, which influences long-term outcomes. A heightened systemic inflammatory response is often induced after TBI, but the underlying pathomech
Externí odkaz:
https://doaj.org/article/fe6482fbcef94a87aa2811f006104fd1
Autor:
Erika d. l. R. M. Cabrera Ranaldi, Karen Nuytemans, Anisley Martinez, Corneliu C. Luca, Robert W. Keane, Juan Pablo de Rivero Vaccari
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 883 (2023)
Parkinson’s disease (PD) is a neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain, the accumulation of α-synuclein aggregates, and motor deficits. A major contributor to dopaminergic neuronal loss is neuroinflamm
Externí odkaz:
https://doaj.org/article/331846a8ebea45b381b9a5bbbe923df4
Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats
Autor:
Anum Ali, Ronald Zambrano, Matthew R. Duncan, Shaoyi Chen, Shihua Luo, Huijun Yuan, Pingping Chen, Merline Benny, Augusto Schmidt, Karen Young, Nadine Kerr, Juan Pablo de Rivero Vaccari, Robert W. Keane, W. Dalton Dietrich, Shu Wu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Hyperoxia-induced lung injury plays a key role in the development of bronchopulmonary dysplasia (BPD), characterized by inflammatory injury and impaired lung development in preterm infants. Although BPD is a predictor of poor neurodevelopmen
Externí odkaz:
https://doaj.org/article/15155bae7ccb4cd9aba80857a69a7304
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Neurodegenerative diseases currently affect millions of people worldwide and continues to increase in the expanding elderly population. Neurodegenerative diseases usually involve cognitive decline and are among the top causes of death. Thus, there is
Externí odkaz:
https://doaj.org/article/b02b88853e624a09b4e4937491b9b12c
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), and it remains the most common immune-mediated disorder affecting the CNS. While the cause of MS is unclear, the underlying pathomechanisms are thought t
Externí odkaz:
https://doaj.org/article/bcadab320da84bd9a9d02f80a9c24047