Výsledky vyhledávání - "Robert W. Gracy"

Anti-apoptotic proteins are oxidized by Aβ25–35 in Alzheimer's fibroblasts

Autor: Susan T. Weintraub, Christina A. Malakowsky, Robert W. Gracy, Craig C. Conrad, J.M. Talent, Joungil Choi, Christopher A. Carroll

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1637:135-141

We have examined the effects of the beta-amyloid peptide (Aβ 25–35 ) on fibroblasts derived from subjects with Alzheimer's disease (AD) and from age-matched controls. The peptide was significantly more cytotoxic to the AD-derived fibroblasts. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a452ff949eae141997c3143e607c021d
https://doi.org/10.1016/s0925-4439(02)00227-2

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Vitamin E prevents oxidation of antiapoptotic proteins in neuronal cells

Autor: Craig C. Conrad, Christina A. Malakowsky, Rong Dai, Susan T. Weintraub, J.M. Talent, Joungil Choi, Robert W. Gracy, Christopher A. Carroll

Publikováno v: PROTEOMICS. 3:73-77

Oxidative damage to neuronal proteins appears to be central to the toxicity associated with a number of neuropathologies, including Alzheimer's disease. We have examined this by using oxidative stress to induce apoptosis in a mouse hippocampal neuron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10440724bc2f5fab7403bdcdc9b18286
https://doi.org/10.1002/pmic.200390011

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Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines

Autor: Chun-Su Yuan, Joungil Choi, Craig C. Conrad, Robert W. Gracy, Christina A. Malakowsky, John M. Talent

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1571:201-210

The oxidative modification of proteins plays a major role in a number of human diseases including Alzheimer's disease (AD). Flavones in extracts of Scutellaria baicalensis (SbE) have been reported to have exceptional antioxidant properties. We examin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7daaba25e1c5aa4f17e744f754caf9
https://doi.org/10.1016/s0304-4165(02)00217-9

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Identification of protein carbonyls after two-dimensional electrophoresis

Autor: Rong Dai, Pamela L. Marshall, John M. Talent, Craig C. Conrad, Joungil Choi, Christina A. Malakowsky, Robert W. Gracy

Publikováno v: PROTEOMICS. 1:829-834

The oxidative modification of proteins plays a major role in a number of human diseases, but identity of the specific proteins that are most susceptible to oxidation has posed a difficult problem. Protein carbonyls are increased after oxidative stres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86f598e76e8777ea693ceb0f81d7ea74
https://doi.org/10.1002/1615-9861(200107)1:7<829::aid-prot829>3.0.co

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Chemiluminescent standards for quantitive comparison of two-dimensional electrophoresis western blots

Autor: Christina A. Malakowsky, Dai Rong, Craig C. Conrad, Robert W. Gracy, Seema Lakdawala, John M. Talent

Publikováno v: PROTEOMICS. 1:365-369

Chemiluminescent probes offer highly sensitive quantitative analyses of proteins blotted from electrophoretic gels onto a supporting matrix (e.g. nitrocellulose or polyvinylidene difluoride). Visualization of signals from probes involves the emission

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4590cb68760f30ebf42b752126f9c7a1
https://doi.org/10.1002/1615-9861(200103)1:3<365::aid-prot365>3.0.co

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Therapeutic nutraceutical treatments for osteoarthritis and ischaemia

Autor: Robert W. Gracy, Geoffrey F Grant

Publikováno v: Expert Opinion on Therapeutic Patents. 10:39-48

There has been a very large increase in nutraceutical innovations, particularly in the US regulatory marketplace. This article reviews the therapeutic potential of a group of nutraceuticals that share common biochemical pathways, and have shown spect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d38f37482ffbcf4a598d10c36335ecaa
https://doi.org/10.1517/13543776.10.1.39

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Effect of hyperbaric oxygen on human skin cells in culture and in human dermal and skin equivalents

Autor: S. Dan Dimitrijevich, Judy R. Wilson, Robert W. Gracy, John G. Mills, Sulabha Paranjape

Publikováno v: Wound Repair and Regeneration. 7:53-64

A critical stage of cutaneous wound healing is the development and maturation of the epidermis. In the aged, and in certain pathologies, this repair process is compromised due to a variety of deficiencies, one of which is tissue oxygenation. Several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f497239ddd5914158a156a8fb45b18f6
https://doi.org/10.1046/j.1524-475x.1999.00053.x

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Molecular wear and tear leads to terminal marking and the unstable isoforms of aging

Autor: John M. Talent, Robert W. Gracy, Anita I. Zvaigzne

Publikováno v: The Journal of Experimental Zoology. 282:18-27

Our studies focus on the mechanisms of molecular wear and tear, terminal marking, protein degradation, and how these processes are altered with age. Molecular wear and tear directly links catalysis with postsynthetic terminal marking. For example, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26ced3852403da42ca78b81857eb7cfb
https://doi.org/10.1002/(sici)1097-010x(199809/10)282:1/2<18::aid-jez5>3.0.co

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