A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain

Autor: Xueming Hu, Lixia Du, Shenbin Liu, Zhou Lan, Kaikai Zang, Jing Feng, Yonghui Zhao, Xingliang Yang, Zili Xie, Peter L. Wang, Aaron M. Ver Heul, Lvyi Chen, Vijay K. Samineni, Yan-Qing Wang, Kory J. Lavine, Robert W. Gereau IV, Gregory F. Wu, Hongzhen Hu

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)

Microglia, resident macrophages of the CNS, are essential to brain development, homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS diseases, including neuropathic pain. However, molecular mechanisms that gover

Externí odkaz: https://doaj.org/article/9981ba42e1df4b6f95aaa052ae104eca

Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain

Autor: Tayler D. Sheahan, Edward R. Siuda, Michael R. Bruchas, Andrew J. Shepherd, Durga P. Mohapatra, Robert W. Gereau, IV, Judith P. Golden

Publikováno v: Neurobiology of Pain, Vol 2, Iss , Pp 1-12 (2017)

It has been suggested that the lack of rodent behavioral assays that represent the complexities of human pain contributes to the poor translational record of basic pain research findings. Clinically, chronic pain interferes with patient mobility and

Externí odkaz: https://doaj.org/article/a9ab6435044a41b4a3a026461eb9aaa1

Impact of Δ9-Tetrahydrocannabinol Administration on Measures of Oxycodone-induced Antinociception, Dependence and Reward in Mice

Autor: Richard Slivicki, Vy Trinh Tran Nhat, Justin G. Wang, Alexxai V. Kravitz, Meaghan C. Creed, Robert W. Gereau IV

Publikováno v: The Journal of Pain. 23:19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d65bb8cb4c40a7ed81489d81e569df6d
https://doi.org/10.1016/j.jpain.2022.03.073

Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia.

Autor: Bhuiyan SA; Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Xu M; Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Alan Edwards Center for Research on Pain and Department of Physiology, McGill University, Montreal, QC, H3G 1Y6, Canada., Yang L; Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA., Semizoglou E; Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Bhatia P; Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Pantaleo KI; Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Tochitsky I; F.M. Kirby Neurobiology Center and Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, 3 Blackfan Cir., Boston, MA 02115, USA., Jain A; F.M. Kirby Neurobiology Center and Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, 3 Blackfan Cir., Boston, MA 02115, USA., Erdogan B; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA., Blair S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA., Cat V; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA., Mwirigi JM; Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA., Sankaranarayanan I; Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA., Tavares-Ferreira D; Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA., Green U; Department of Pathology, Center for Integrated Diagnostics, Massachussetts General Hospital and Havard Medical School, Boston, MA 02114, USA., McIlvried LA; Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA., Copits BA; Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA., Bertels Z; Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA., Del Rosario JS; Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA., Widman AJ; Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA., Slivicki RA; Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA., Yi J; Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA., Sharif-Naeini R; Alan Edwards Center for Research on Pain and Department of Physiology, McGill University, Montreal, QC, H3G 1Y6, Canada., Woolf CJ; F.M. Kirby Neurobiology Center and Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, 3 Blackfan Cir., Boston, MA 02115, USA., Lennerz JK; Department of Pathology, Center for Integrated Diagnostics, Massachussetts General Hospital and Havard Medical School, Boston, MA 02114, USA., Whited JL; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA., Price TJ; Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA., Robert W Gereau Iv; Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA., Renthal W; Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Publikováno v: Science advances [Sci Adv] 2024 Jun 21; Vol. 10 (25), pp. eadj9173. Date of Electronic Publication: 2024 Jun 21.