Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Robert W. Chesnut"'
Autor:
Kathryn E. Carlson, Hai-Bing Zhou, Abhishek Sharma, Jerome C. Nwachukwu, Chune Dong, Zong Quan Liao, Sathish Srinivasan, John A. Katzenellenbogen, Robert W. Chesnut, Kendall W. Nettles
Publikováno v:
Journal of Medicinal Chemistry
We have explored the isoelectronic replacement of the C═C double bond found at the core of many nonsteroidal estrogen ligands with a simple Schiff base (C═N). Di- and triaryl-substituted imine derivatives were conveniently prepared by the condens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0053d1fc1b24c7b5b30e709619882916
https://doi.org/10.1021/jm500268j
https://doi.org/10.1021/jm500268j
Autor:
Robert W. Chesnut, Philip J. R. Goulder, Spyros A. Kalams, Christian Brander, John Fikes, Bruce D. Walker, Mark J. Newman, Marcus Altfeld, Susan Buchbinder, Peggy Wentworth, Robert L. Eldridge, Alessandro Sette, Eric S. Rosenberg, Marylyn M. Addo, Amy K. Shea, Brian D. Livingston, Paul E. Sax, Steve Boswell, Neha Reshamwala, John Sidney, Phuong Thi Nguyen, Theresa Flynn, Gregory K. Robbins
Virus-specific cytotoxic T-lymphocyte (CTL) responses are critical in the control of human immunodeficiency virus type 1 (HIV-1) infection and will play an important part in therapeutic and prophylactic HIV-1 vaccines. The identification of virus-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36d59dbb958b5f98b277ba3df1c746c
https://doi.org/10.1128/jvi.75.3.1301-1311.2001
https://doi.org/10.1128/jvi.75.3.1301-1311.2001
Autor:
Brian D. Livingston, Alessandro Sette, Robert W. Chesnut, Max Essex, Mark Newman, Cara C. Wilson, Rhonda Skvoretz, Vladimir Novitsky, Denise M. McKinney, Michelle Anders
Publikováno v:
The Journal of Immunology. 173:1941-1950
Recognition by CD8+ T lymphocytes (CTL) of epitopes that are derived from conserved gene products, such as Gag and Pol, is well documented and conceptually supports the development of epitope-based vaccines for use against diverse HIV-1 subtypes. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9273b02ac59fec115728af9216ce186d
https://doi.org/10.4049/jimmunol.173.3.1941
https://doi.org/10.4049/jimmunol.173.3.1941
Autor:
Jeri E. Forster, Claire Crimi, Mark Newman, Brian D. Livingston, Cara C. Wilson, Alessandro Sette, Samantha MaWhinney, Scott Southwood, Michelle Anders, Robert W. Chesnut, Denise M. McKinney
Publikováno v:
The Journal of Immunology. 171:5611-5623
Epitope-based vaccines designed to induce CTL responses specific for HIV-1 are being developed as a means for addressing vaccine potency and viral heterogeneity. We identified a set of 21 HLA-A2, HLA-A3, and HLA-B7 restricted supertype epitopes from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486f8fa3629ae6eb63e77f95b53c5938
https://doi.org/10.4049/jimmunol.171.10.5611
https://doi.org/10.4049/jimmunol.171.10.5611
Autor:
Jason S. Bundy, Sara E. Bendler, Diana N. Davis, Sarah A. Clark, Nicole A. Orwar, Robert W. Chesnut
Publikováno v:
Synthetic Communications. 33:3365-3371
ω-Iodoalkyl(methyl)malonate esters have potential utility in the bioconjugate chemistry of steroids. A representative set of these esters with a variety of protecting groups and alkyl groups has been prepared. The compounds offer a range of elution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ed6984890b529b12dc8bd5c291a8d0
https://doi.org/10.1081/scc-120023994
https://doi.org/10.1081/scc-120023994
Autor:
Mark Newman, Brian D. Livingston, Robert W. Chesnut, Alessandro Sette, Dennis McKinney, Cara C. Wilson
Publikováno v:
Clinical and Applied Immunology Reviews. 3:157-166
The demonstration that highly active anti-retroviral therapy (HAART) can control human immunodeficiency virus type 1 (HIV-1) viral replication and the associated destruction of the immune system provides an opportunity to implement therapeutic vaccin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec42709d810aed1c4937cfdcfa15cb75
https://doi.org/10.1016/s1529-1049(02)00161-7
https://doi.org/10.1016/s1529-1049(02)00161-7
Autor:
Howard M. Grey, Robert W. Chesnut
Publikováno v:
Immunology today. 6(3)
In this article Howard Grey and Robert Chesnut describe recent insights into the mechanism of antigen presentation and discuss the needfor antigen processing in the stimulation of T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8f12a94ef2a1937a3c64d79bea0c86
https://pubmed.ncbi.nlm.nih.gov/25291539
https://pubmed.ncbi.nlm.nih.gov/25291539
Autor:
Robert W. Chesnut, Alessandro Sette, John L. Dzuris, Donald K. Carter, John Sidney, David I. Watkins, Helen Horton, Rose Correa
Publikováno v:
Journal of Virology. 75:10958-10968
Major histocompatibility complex class II molecules encoded by two common rhesus macaque alleles Mamu-DRB1*0406 and Mamu-DRB*w201 have been purified, and quantitative binding assays have been established. The structural requirements for peptide bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48da88f156b681b850428ad000ad9e9a
https://doi.org/10.1128/jvi.75.22.10958-10968.2001
https://doi.org/10.1128/jvi.75.22.10958-10968.2001
Autor:
Denise M. McKinney, Mark Newman, Brian D. Livingston, Alessandro Sette, Claire Crimi, Robert W. Chesnut
Publikováno v:
Vaccine. 19:4652-4660
Experimental DNA vaccines comprised of multiple minimal cytotoxic T lymphocytes (CTL) epitopes can effectively induce broad CTL responses; however, such constructs frequently exhibit significant variation in epitope immunogenicity. Antigenicity assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72cd800c4b4ae4066b17c81cc51d3c0
https://doi.org/10.1016/s0264-410x(01)00233-x
https://doi.org/10.1016/s0264-410x(01)00233-x
Autor:
Scott Southwood, John Fikes, Elissa Keogh, Robert W. Chesnut, Esteban Celis, Alessandro Sette
Publikováno v:
The Journal of Immunology. 167:787-796
Forty-two wild-type and analogue peptides derived from p53, carcinoembryonic Ag, Her2/neu, and MAGE2/3 were screened for their capacity to induce CTLs, in vitro, capable of recognizing tumor target lines. All the peptides bound HLA-A*0201 and two or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac6f65d87e2de2ff05b959d663d9560
https://doi.org/10.4049/jimmunol.167.2.787
https://doi.org/10.4049/jimmunol.167.2.787