Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robert W. Bondi"'
Autor:
Emile P. Chen, Robert W. Bondi, Carolyn Zhang, Daniel J. Price, Ming-Hsun Ho, Kira A. Armacost, Michael P. DeMartino
Publikováno v:
Journal of Medicinal Chemistry. 65:6926-6939
Many critical decisions faced in early discovery require a thorough understanding of the dynamic behavior of pharmacological pathways following target engagement. From fundamental decisions on the optimal target to pursue and the ultimate drug produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7aa9237fdc11697472e46cb9c4e4bb
https://doi.org/10.1021/acs.jmedchem.2c00330
https://doi.org/10.1021/acs.jmedchem.2c00330
Publikováno v:
Journal of Medicinal Chemistry. 64:3185-3196
The optimal pharmacokinetic (PK) required for a drug candidate to elicit efficacy is highly dependent on the targeted pharmacology, a relationship that is often not well characterized during early phases of drug discovery. Generic assumptions around
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdd7b5a82f846d2647a435656a90d30
https://doi.org/10.1021/acs.jmedchem.0c02033
https://doi.org/10.1021/acs.jmedchem.0c02033
Publikováno v:
Reaction Chemistry & Engineering. 5:1642-1646
In-line Fourier transform mid-infrared spectroscopy (FTIR) was used to monitor a reaction which had a highly inconsistent rate due to sensitivity to changes in process parameters and the quality of the starting materials. Accurate determination of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27011a0525720612d7a01e0b8c2409cb
https://doi.org/10.1039/d0re00182a
https://doi.org/10.1039/d0re00182a
In-line mid-infrared spectroscopy (FTIR) was used to monitor a reaction which had a highly inconsistent rate due to sensitivity to changes in process parameters and the quality of the starting materials. Accurate determination of the endpoint in real
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b7b76fd0fd9b6c3375520e0bb528d8
https://doi.org/10.26434/chemrxiv.12163608
https://doi.org/10.26434/chemrxiv.12163608
Autor:
James K. Drennen, Robert W. Bondi, Benoît Igne, Carl A. Anderson, Douglas Steinbach, Gary McGeorge
Publikováno v:
Journal of Pharmaceutical Innovation. 12:347-356
Global regulatory agencies have encouraged the use of process analytical technology (PAT) to assure quality in the pharmaceutical industry. A frequently cited obstacle to the implementation of spectroscopy-based PAT methods is the difficulty associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5afd8d907a424ea3ca757757183652ef
https://doi.org/10.1007/s12247-017-9299-4
https://doi.org/10.1007/s12247-017-9299-4
Publikováno v:
Applied Spectroscopy. 71:1856-1867
Polymorph detection is critical for ensuring pharmaceutical product quality in drug substances exhibiting polymorphism. Conventional analytical techniques such as X-ray powder diffraction and solid-state nuclear magnetic resonance are utilized primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8189dd11b3158a835a1f615b44f602
https://doi.org/10.1177/0003702817690407
https://doi.org/10.1177/0003702817690407
Autor:
Christian Airiau, Chris Antoniou, Massimiliano Barolo, Fabrizio Bezzo, Robert W. Bondi, Johan Bøtker, Richard D. Braatz, Dongsheng Bu, Chunsheng Cai, Graham Cook, Claudia C. Corredor, Kim H. Esbensen, Pierantonio Facco, Pedro M. Felizardo, Ana Patricia Ferreira, Geir Rune Flåten, John Gamble, Joerg Gampfer, Paul Geladi, Francisca F. Gouveia, Hans Grahn, Mark J. Henson, Benoît Igne, Dominique S. Kummli, Lorenz Liesum, João A. Lopes, David Lovett, John Mack, Nuno Matos, Neil McDowall, Gary McGeorge, Natascia Meneghetti, José C. Menezes, Ewan Mercer, Charles E. Miller, Chris Morris, Venkatesh Natarajan, Sarah Nicholson, Julia O’Neill, Antonio Peinado, Alan R. Potts, Jukka Rantanen, Clare Frances Rawlinson-Malone, Rodolfo J. Romañach, Andrés D. Román-Ospino, Mafalda C. Sarraguça, Kristen A. Severson, Zhenqi Shi, Christopher M. Sinko, Brad Swarbrick, Furqan Tahir, Jörg Thömmes, Mike Tobyn, Jeremy G. VanAntwerp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85fb5a702d533aa4c23f7aa952314506
https://doi.org/10.1016/b978-0-12-811065-2.00030-8
https://doi.org/10.1016/b978-0-12-811065-2.00030-8
This chapter presents case studies of the application of multivariate data analysis to the development and manufacture of active pharmaceutical ingredients. It covers the topics of process understanding and process control and presents chemometrics a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dad9d980def450db1866f662c8a6447d
https://doi.org/10.1016/b978-0-12-811065-2.00009-6
https://doi.org/10.1016/b978-0-12-811065-2.00009-6
Autor:
Johannes Khinast, Stephan Sacher, Otto Scheibelhofer, Robert W. Bondi, Bianca Grabner, Benoît Igne
Publikováno v:
Journal of Pharmaceutical Sciences. 104:2312-2322
Spectroscopic methods are increasingly used for monitoring pharmaceutical manufacturing unit operations that involve powder handling and processing. With that regard, chemometric models are required to interpret the obtained spectra. There are many w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0fd142af1750663c101b4a1bec4d91
https://doi.org/10.1002/jps.24488
https://doi.org/10.1002/jps.24488
Publikováno v:
Applied Spectroscopy. 66:1442-1453
Near-infrared spectroscopy (NIRS) is a valuable tool in the pharmaceutical industry, presenting opportunities for online analyses to achieve real-time assessment of intermediates and finished dosage forms. The purpose of this work was to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbeec64e51344e1922c6ec8b91a069b
https://doi.org/10.1366/12-06689
https://doi.org/10.1366/12-06689