Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert W. Allcock"'
Autor:
Jana Bogum, Robert W. Allcock, Elisabeth K. Martin, Elaine Huston, Tracy Riddell, Daniel M. Houslay, Frank Christian, Miles D. Houslay, Zhong Jiang, Barbara Lindsay, Achamma Abraham, Enno Klussmann, George S. Baillie, David R. Adams, Jonathan P. Day, Sebastian Sookup, Georgina M. Rosair, Robert L. Rae, Diana F. Anthony
Publikováno v:
Journal of Medicinal Chemistry. 54:3331-3347
A survey of PDE4 inhibitors reveals that some compounds trigger intracellular aggregation of PDE4A4 into accretion foci through association with the ubiquitin-binding scaffold protein p62 (SQSTM1). We show that this effect is driven by inhibitor occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fb40712efded0dfb998a6028221ddc
https://doi.org/10.1021/jm200070e
https://doi.org/10.1021/jm200070e
Autor:
John P. McAbney, Nicole M. Kane, Graeme Milligan, Angela McCahill, Jane Gilmour, Miles D. Houslay, David R. Adams, Robert W. Allcock, Peter Burton, Fergus R. McKenzie, Andrew H. Baker, Zhong Jiang, George S. Baillie, Joanne C. Mountford, Achamma Abraham
Publikováno v:
Biochemical Society Transactions. 38:1058-1061
hESCs (human embryonic stem cells) offer great potential for pharmaceutical research and development and, potentially, for therapeutic use. However, improvements in cell culture are urgently required to allow the scalable production of large numbers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59a0bdff8317c3858a97377bc9e5717
https://doi.org/10.1042/bst0381058
https://doi.org/10.1042/bst0381058
Autor:
Robert W. Allcock, Yasushi Kohno, David R. Adams, Keith M. Morgan, Ian D. Collier, Patrick D. Bailey, Georgina M. Rosair, Karen A. Johnston, Haakon Blakli, Zhong Jiang
Publikováno v:
Org. Biomol. Chem.. 6:175-186
Cycloaddition of pyridine N-imine with 6-alkyl-4-oxohex-5-ynoates followed by condensation with hydrazine provides concise access to pharmacologically active 6-(pyrazolo[1,5-a]pyridin-3-yl)pyridazinones. For the first time alkynyl heterocycles are al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a222786961860dcb76d2e5c5caffbed0
https://doi.org/10.1039/b713638b
https://doi.org/10.1039/b713638b
Autor:
Robert W. Allcock, Satoshi Takita, Tetsuya Kishi, Tomohiko Eiraku, Zhong Jiang, Tokutaro Yasue, David R. Adams, Koji Ochiai, Yasushi Kohno, Kazunori Fukuchi, Kazuhiko Iwase, Akihiko Kojima
Publikováno v:
Bioorganicmedicinal chemistry. 20(5)
(-)-6-(7-Methoxy-2-trifluoromethylpyrazolo[1,5-a]pyridin-4-yl)-5-methyl-4,5-dihydro-3-(2H)-pyridazinone (KCA-1490) is a dual PDE3/4 inhibitor that exhibits potent combined bronchodilatory and anti-inflammatory activity. A survey of potential bicyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921d6e87ff2cba21fc2b94792bab96eb
https://pubmed.ncbi.nlm.nih.gov/22336247
https://pubmed.ncbi.nlm.nih.gov/22336247
Autor:
Yasushi Kohno, Karen A. Johnston, Robert W. Allcock, Keith M. Morgan, Georgina M. Rosair, Zhong Jiang, David R. Adams, Kazuhiko Iwase, Haakon Blakli
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(11)
Ibudilast [1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one] is a nonselective phosphodiesterase inhibitor used clinically to treat asthma. Efforts to selectively develop the PDE3- and PDE4-inhibitory activity of ibudilast led to repla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a5bfd5255da6b3846203b01a70347d
https://pubmed.ncbi.nlm.nih.gov/21530250
https://pubmed.ncbi.nlm.nih.gov/21530250
Autor:
Robert W. Allcock, John P. McAbney, Zhong Jiang, Nicole M. Kane, David R. Adams, Graeme Milligan, Joanne C. Mountford, Peter Burton, Alexandra Kaupisch, Achamma Abraham, Jane Gilmour, Angela McCahill, Miles D. Houslay, Andrew H. Baker, George S. Baillie
Publikováno v:
Biochemical Journal
Biochemical Journal, Portland Press, 2010, 432 (3), pp.575-584. ⟨10.1042/BJ20100726⟩
Biochemical Journal, Portland Press, 2010, 432 (3), pp.575-584. ⟨10.1042/BJ20100726⟩
hESCs (human embryonic stem cells) have enormous potential for use in pharmaceutical development and therapeutics; however, to realize this potential, there is a requirement for simple and reproducible cell culture methods that provide adequate numbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35cf3c6b7f2161176ea04b2350c7de2
https://hal.archives-ouvertes.fr/hal-00539721/file/PEER_stage2_10.1042%2FBJ20100726.pdf
https://hal.archives-ouvertes.fr/hal-00539721/file/PEER_stage2_10.1042%2FBJ20100726.pdf
Autor:
Keith M. Morgan, Ian D. Collier, Haakon Blakli, Robert W. Allcock, Zhong Jiang, Patrick D. Bailey, David R. Adams, Karen A. Johnston, Yasushi Kohno, Georgina M. Rosair
Publikováno v:
ChemInform. 39
Cycloaddition of pyridine N-imine with 6-alkyl-4-oxohex-5-ynoates followed by condensation with hydrazine provides concise access to pharmacologically active 6-(pyrazolo[1,5-a]pyridin-3-yl)pyridazinones. For the first time alkynyl heterocycles are al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ae84fff6e7c878b125d693ba5098333
https://doi.org/10.1002/chin.200823148
https://doi.org/10.1002/chin.200823148
Publikováno v:
ChemInform. 32
Oxidation of readily available aminonaphthols 7a and 7b with activated manganese dioxide gives palmarumycin analogues 8a and 8b in good yield. The related benzoquinone monoacetals 10a–c undergo cycloaddition with 3-methoxy-2-pyrone at high pressure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aee0c6e37fdbd92168c43a52ec9e376f
https://doi.org/10.1002/chin.200108221
https://doi.org/10.1002/chin.200108221
Autor:
Peter Burton, David R. Adams, Achamma Abraham, Robert W. Allcock, Zhong Jiang, Angela McCahill, Jane Gilmour, John McAbney, Alexandra Kaupisch, Nicole M. Kane, George S. Baillie, Andrew H. Baker, Graeme Milligan, Miles D. Houslay, Joanne C. Mountford
Publikováno v:
Biochemical Journal; Nov2010, Vol. 432 Issue 3, p575-584, 10p
Autor:
Paul D. Andrews, Melissa Becroft, Anders Aspegren, Jane Gilmour, Martyn J. James, Scott McRae, Robert Kime, Robert W. Allcock, Achamma Abraham, Zhong Jiang, Raimund Strehl, Joanne C. Mountford, Graeme Milligan, Miles D. Houslay, David R. Adams, Julie A. Frearson
Publikováno v:
Biochemical Journal; Oct2010, Vol. 432 Issue 1, p21-33, 13p