Zobrazeno 1 - 10
of 313
pro vyhledávání: '"Robert W. Shafer"'
Autor:
Kaiming Tao, Zachary A. Osman, Philip L. Tzou, Soo-Yon Rhee, Vineet Ahluwalia, Robert W. Shafer
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Large language models (LLMs) that can efficiently screen and identify studies meeting specific criteria would streamline literature reviews. Additionally, those capable of extracting data from publications would enhance knowledge
Externí odkaz:
https://doaj.org/article/644a26d55740400eb9522b8dba4a1b4f
Autor:
Soo-Yon Rhee, Jonathan M. Schapiro, Francesco Saladini, Maurizio Zazzi, Saye Khoo, Robert W. Shafer
Publikováno v:
AIDS Research and Therapy, Vol 20, Iss 1, Pp 1-7 (2023)
Abstract Background Doravirine has a unique resistance profile but how this profile might increase its usefulness beyond first-line therapy in persons with susceptible viruses has not been well studied. We sought to determine scenarios in which dorav
Externí odkaz:
https://doaj.org/article/340f8b9f65814638bf998974eaba7a3f
Autor:
Carolyn Chu, Kaiming Tao, Vinie Kouamou, Ava Avalos, Jake Scott, Philip M. Grant, Soo-Yon Rhee, Suzanne M. McCluskey, Michael R. Jordan, Rebecca L. Morgan, Robert W. Shafer
Publikováno v:
Viruses, Vol 16, Iss 3, p 399 (2024)
Background: Dolutegravir (DTG) is a cornerstone of global antiretroviral (ARV) therapy (ART) due to its high efficacy and favorable tolerability. However, limited data exist regarding the risk of emergent integrase strand transfer inhibitor (INSTI) d
Externí odkaz:
https://doaj.org/article/34d25c7a03884a529279d268af3e72b0
Autor:
Seth C Inzaule, Mark J Siedner, Susan J Little, Santiago Avila-Rios, Alisen Ayitewala, Ronald J Bosch, Vincent Calvez, Francesca Ceccherini-Silberstein, Charlotte Charpentier, Diane Descamps, Susan H Eshleman, Joseph Fokam, Lisa M Frenkel, Ravindra K Gupta, John P A Ioannidis, Pontiano Kaleebu, Rami Kantor, Seble G Kassaye, Sergei L Kosakovsky Pond, Vinie Kouamou, Roger D Kouyos, Daniel R Kuritzkes, Richard Lessells, Anne-Genevieve Marcelin, Lawrence Mbuagbaw, Brian Minalga, Nicaise Ndembi, Richard A Neher, Roger Paredes, Deenan Pillay, Elliot G Raizes, Soo-Yon Rhee, Douglas D Richman, Kiat Ruxrungtham, Pardis C Sabeti, Jonathan M Schapiro, Sunee Sirivichayakul, Kim Steegen, Wataru Sugiura, Gert U van Zyl, Anne-Mieke Vandamme, Annemarie M J Wensing, Joel O Wertheim, Huldrych F Gunthard, Michael R Jordan, Robert W Shafer
Publikováno v:
PLoS Medicine, Vol 20, Iss 9, p e1004293 (2023)
• Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that
Externí odkaz:
https://doaj.org/article/c16a34440b374c53938659e86b679144
Autor:
Kaiming Tao, Soo-Yon Rhee, Carolyn Chu, Ava Avalos, Amrit K. Ahluwalia, Ravindra K. Gupta, Michael R. Jordan, Robert W. Shafer
Publikováno v:
Viruses, Vol 15, Iss 9, p 1932 (2023)
Background: Dolutegravir (DTG)-based antiretroviral therapy (ART) rarely leads to virological failure (VF) and drug resistance in integrase strand transfer inhibitor (INSTI)-naïve persons living with HIV (PLWH). As a result, limited data are availab
Externí odkaz:
https://doaj.org/article/3a28918654bd457bb65dba523a8d432e
Autor:
Seth A. Hoffman, Cristina Costales, Malaya K. Sahoo, Srikanth Palanisamy, Fumiko Yamamoto, ChunHong Huang, Michelle Verghese, Daniel A. Solis, Mamdouh Sibai, Aruna Subramanian, Lucy S. Tompkins, Philip Grant, Robert W. Shafer, Benjamin A. Pinsky
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 10, Pp 2720-2723 (2021)
We report persistent severe acute respiratory syndrome coronavirus 2 infection in a patient with HIV/AIDS; the virus developed spike N terminal domain and receptor binding domain neutralization resistance mutations. Our findings suggest that immunoco
Externí odkaz:
https://doaj.org/article/68f1f33cf89a40c099c342a2b7541032
Autor:
Kaiming Tao, Philip L. Tzou, Sergei L. Kosakovsky Pond, John P. A. Ioannidis, Robert W. Shafer
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT SARS-CoV-2 Omicron variants contain many mutations in its spike receptor-binding domain, the target of all authorized monoclonal antibodies (MAbs). Determining the extent to which Omicron variants reduced MAb susceptibility is critical to pr
Externí odkaz:
https://doaj.org/article/b8a461e8a712480b863faa163a6ba332
Autor:
Kaiming Tao, Soo-Yon Rhee, Philip L. Tzou, Zachary A. Osman, Sergei L. Kosakovsky Pond, Susan P. Holmes, Robert W. Shafer
Publikováno v:
Viruses, Vol 15, Iss 4, p 992 (2023)
Background: With the approval of the HIV-1 capsid inhibitor, lenacapavir, capsid sequencing will be required for managing lenacapavir-experienced individuals with detectable viremia. Successful sequence interpretation will require examining new capsi
Externí odkaz:
https://doaj.org/article/660e68dcdb55445589d9c342138cbab0
Autor:
Nicaise Ndembi, Fati Murtala-Ibrahim, Monday Tola, Jibreel Jumare, Ahmad Aliyu, Peter Alabi, Charles Mensah, Alash’le Abimiku, Miguel E. Quiñones-Mateu, Trevor A. Crowell, Soo-Yon Rhee, Robert W. Shafer, Ravindra Gupta, William Blattner, Manhattan E. Charurat, Patrick Dakum
Publikováno v:
AIDS Research and Therapy, Vol 17, Iss 1, Pp 1-11 (2020)
Abstract Background A substantial number of persons living with HIV (PLWH) in Nigeria do not experience durable viral suppression on first-line antiretroviral therapy (ART). Understanding risk factors for first-line treatment failure informs patient
Externí odkaz:
https://doaj.org/article/9821cf69e52141a5aae4a8ad616670ca
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Background Only a few recent reports have examined longitudinal adherence patterns in US clinics and its impact on immunological and virological outcomes among large cohorts initiating contemporary antiretroviral therapy (ART) in US clinics. Methods
Externí odkaz:
https://doaj.org/article/668c7207137f47b7b323ac8404af4250