Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Robert W Wilkinson"'
Publikováno v:
SLAS Discovery, Vol 27, Iss 2, Pp 95-106 (2022)
The field of Immuno-Oncology (IO) is evolving to utilise novel antibody backbones that can co-target multiple cell-surface stimulatory and inhibitory co-receptors (SICR). This approach necessitates a better understanding of SICR co-expression at the
Externí odkaz:
https://doaj.org/article/9087a34ea27f4b3ea19c5bd2348d173a
Autor:
Robert W Wilkinson, Hormas Ghadially, Stacy Kentner, Suzanne Isabelle Sitnikova, Sophie Munnings-Tomes, Elena Galvani, Kathy Mulgrew, Chris Rands, Judit España Agustí, Tianhui Zhang, Kristina M Ilieva, Guglielmo Rosignoli, Matthew J Robinson, Tim Slidel, Simon J Dovedi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Immuno-oncology therapies are now part of the standard of care for cancer in many indications. However, durable objective responses remain limited to a subset of patients. As such, there is a critical need to identify biomarkers that can p
Externí odkaz:
https://doaj.org/article/0daba65ab2174eb2906d5b3b2486abf0
Autor:
Damien J Zanker, Alex J Spurling, Natasha K Brockwell, Katie L Owen, Jasmine M Zakhour, Tina Robinson, Hendrika M Duivenvoorden, Paul J Hertzog, Stefanie R Mullins, Robert W Wilkinson, Belinda S Parker
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 9, Pp n/a-n/a (2020)
Abstract Objectives Loss of tumor‐inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progression via decreased immunogenicity and antitumor immunity. Previous studies in murine models of triple‐negative
Externí odkaz:
https://doaj.org/article/61578605bee846698ae1d74398aee779
Autor:
Suzanne I. Sitnikova, Jennifer A. Walker, Laura B. Prickett, Michelle Morrow, Viia E. Valge-Archer, Matthew J. Robinson, Robert W. Wilkinson, Simon J. Dovedi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionImmuno-oncology (IO) research relies heavily on murine syngeneic tumor models. However, whilst the average age for a cancer diagnosis is 60 years or older, for practical purposes the majority of preclinical studies are conducted in young
Externí odkaz:
https://doaj.org/article/1b4f24a133924f28b0538a31b1ac7be8
Autor:
Rich Woessner, Alexandra Borodovsky, Kris Sachsenmeier, Felix Scheuplein, Robert W. Wilkinson, Chaoyang Ye, Simon Dovedi
Publikováno v:
Animal Models for the Development of Cancer Immunotherapy. :11-62
Small gene networks delineate immune cell states and characterize immunotherapy response in melanoma
Autor:
Donagh Egan, Martina Kreileder, Myriam Nabhan, Luis F. Iglesias-Martinez, Simon J. Dovedi, Viia Valge-Archer, Amit Grover, Robert W. Wilkinson, Timothy Slidel, Claus Bendtsen, Ian P. Barrett, Donal J. Brennan, Walter Kolch, Vadim Zhernovkov
Publikováno v:
Cancer Immunology Research.
Single-cell technologies have elucidated mechanisms responsible for immune checkpoint inhibitor (ICI) response, but are not amenable to a clinical diagnostic setting. In contrast, bulk RNA sequencing (RNA-seq) is now routine for research and clinical
Autor:
Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi
Supplementary Materials and Methods, and Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b4ab5c831dd6063dffdf564c8ad3c
https://doi.org/10.1158/2159-8290.22540037
https://doi.org/10.1158/2159-8290.22540037
Autor:
Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca7eaed273b219faf1bb63ec9cf8694
https://doi.org/10.1158/2159-8290.c.6549263
https://doi.org/10.1158/2159-8290.c.6549263
Autor:
Robert W. Wilkinson, Simon J. Dovedi, Ross Stewart, Viia Valge-Archer, Michelle Morrow, James A. Harper, Hazel Jones, Matthew McCourt, Brandon W. Higgs, Philip Brohawn, Jane Coates Ulrichsen, Amanda Watkins, Judith Anderton, Danielle Marcus, Luciano Pacelli, Stefanie Mullins, Rebecca Leyland, Miika J. Ahdesmaki, Danielle M. Greenawalt, Dennis Y.Q. Wang, Jens-Oliver Koopmann, Richard C.A. Sainson, John E. Prime, Suzanne I.S. Mosely
Murine syngeneic tumor models are critical to novel immuno-based therapy development, but the molecular and immunologic features of these models are still not clearly defined. The translational relevance of differences between the models is not fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adcb199105c771e6b82b33f00095d352
https://doi.org/10.1158/2326-6066.c.6548411.v1
https://doi.org/10.1158/2326-6066.c.6548411.v1
Autor:
Robert W. Wilkinson, Simon J. Dovedi, Ross Stewart, Viia Valge-Archer, Michelle Morrow, James A. Harper, Hazel Jones, Matthew McCourt, Brandon W. Higgs, Philip Brohawn, Jane Coates Ulrichsen, Amanda Watkins, Judith Anderton, Danielle Marcus, Luciano Pacelli, Stefanie Mullins, Rebecca Leyland, Miika J. Ahdesmaki, Danielle M. Greenawalt, Dennis Y.Q. Wang, Jens-Oliver Koopmann, Richard C.A. Sainson, John E. Prime, Suzanne I.S. Mosely
Supplementary Figure S1: Summary of experiments Supplementary Figure S2: Gating strategy Supplementary Figure S3:Profiling by array CGH, whole-exome and targeted sequencing Supplementary Figure S4: Comparison of mutational profiles of murine syngenei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f963acbe001e8dcef590d845d2ff257
https://doi.org/10.1158/2326-6066.22537352.v1
https://doi.org/10.1158/2326-6066.22537352.v1