NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture.

Autor: Denise C Cornelius, Olivia K Travis, Robert W Tramel, Marivee Borges-Rodriguez, Cedar H Baik, Mallory Greer, Chelsea A Giachelli, Geilda A Tardo, Jan M Williams

Publikováno v: PLoS ONE, Vol 15, Iss 6, p e0234039 (2020)

Sepsis is characterized by organ dysfunction due to a dysregulated immune response to infection. Currently, no effective treatment for sepsis exists. Platelets are recognized as mediators of the immune response and may be a potential therapeutic targ

Externí odkaz: https://doaj.org/article/586ca57a4c8b43a3acfdc9d6a68b23b1

Platelet Inhibition Prevents NLRP3 Inflammasome Activation and Sepsis-Induced Kidney Injury

Autor: Chelsea Giachelli, Cedar H. Baik, Olivia K. Travis, Geilda A. Tardo, Marivee Borges-Rodriguez, Corbin A. Shields, Denise C. Cornelius, Jan M. Williams, Robert W. Tramel

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10330, p 10330 (2021)

Platelets, cellular mediators of thrombosis, are activated during sepsis and are increasingly recognized as mediators of the immune response. Platelet activation is significantly increased in sepsis patients compared to ICU control patients. Despite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce658e4d680512d793b4abd889115d7a
https://pubmed.ncbi.nlm.nih.gov/34638670

Phosphatidylserine expressing platelet microparticle levels at hospital presentation are decreased in sepsis non-survivors and correlate with thrombocytopenia

Autor: Sibali Bandyopadhyay, Alan E. Jones, Michael A. Puskarich, Robert W. Tramel, Maggie McCalmon, Denise C. Cornelius, Wood D. Dale

Publikováno v: Thrombosis research. 168

BACKGROUND: Sepsis induced platelet activation releases platelet microparticles (PMPs). PMPs express phosphatidylserine (PS) and can serve as a scaffold for the prothrombinase complex, thereby promoting coagulation. Studies of PMPs in intensive care

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5d94f0df93c5f0e4bd4b83a83fa187
https://pubmed.ncbi.nlm.nih.gov/30060877

Evaluation of Two High-Order Weighted Essentially Nonoscillatory Schemes

Autor: Robert H. Nichols, Robert W. Tramel, Pieter G. Buning

Publikováno v: AIAA Journal. 46:3090-3102

Two fifth-order spatial weighted essentially nonoscillatory schemes for the convective terms were added to the OVERFLOW 2 implicit overset Navier-Stokes flow solver. The method used to incorporate the schemes is similar to a monotone upstream-centere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbca154429bbd8d3ea1eec39a484aa49
https://doi.org/10.2514/1.36849

Addition of Improved Shock-Capturing Schemes to OVERFLOW 2.1

Autor: Pieter G. Burning, Robert W. Tramel, Robert H. Nichols

Publikováno v: 19th AIAA Computational Fluid Dynamics.

Existing approximate Riemann solvers do not perform well when the grid is not aligned with strong shocks in the flow field. Three new approximate Riemann algorithms are investigated to improve solution accuracy and stability in the vicinity of strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9f45702a86fffd12a39d71805d9339d
https://doi.org/10.2514/6.2009-3988