Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Robert W Mills"'
Autor:
Nora Linscheid, Alberto Santos, Pi Camilla Poulsen, Robert W Mills, Kirstine Calloe, Ulrike Leurs, Johan Z Ye, Christian Stolte, Morten B Thomsen, Bo H Bentzen, Pia R Lundegaard, Morten S Olesen, Lars J Jensen, Jesper V Olsen, Alicia Lundby
Publikováno v:
PLoS Biology, Vol 19, Iss 4, p e3001144 (2021)
Delineating human cardiac pathologies and their basic molecular mechanisms relies on research conducted in model organisms. Yet translating findings from preclinical models to humans present a significant challenge, in part due to differences in card
Externí odkaz:
https://doaj.org/article/803278d7d2314c97a5198af5d5449f9c
Autor:
Jordan S. Leyton-Mange, Robert W. Mills, Vincenzo S. Macri, Min Young Jang, Faraz N. Butte, Patrick T. Ellinor, David J. Milan
Publikováno v:
Stem Cell Reports, Vol 2, Iss 2, Pp 163-170 (2014)
In addition to their promise in regenerative medicine, pluripotent stem cells have proved to be faithful models of many human diseases. In particular, patient-specific stem cell-derived cardiomyocytes recapitulate key features of several life-threate
Externí odkaz:
https://doaj.org/article/279e7a5e797148158615c7e16a830fbd
Autor:
Saagar Mahida, Simon Modi, Derick Todd, Robert W. Mills, Wern Yew Ding, Charles M. Pearman, Nathan Denham, Mark C.S. Hall
Publikováno v:
Human Mutation
Pearman, C, Denham, N, Mills, R W, Ding, W Y, Hall, M C S, Todd, D M & Mahida, S 2020, ' Relationship Between Sodium Channel Function and Clinical Phenotype in SCN5A Variants Associated with Brugada syndrome ', Human Mutation . https://doi.org/10.1002/humu.24128
Pearman, C, Denham, N, Mills, R W, Ding, W Y, Hall, M C S, Todd, D M & Mahida, S 2020, ' Relationship Between Sodium Channel Function and Clinical Phenotype in SCN5A Variants Associated with Brugada syndrome ', Human Mutation . https://doi.org/10.1002/humu.24128
The identification of a pathogenic SCN5A variant confers an increased risk of conduction defects and ventricular arrhythmias (VA) in Brugada syndrome (BrS). However, specific aspects of sodium channel function that influence clinical phenotype have n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcff502438a41857a341c88f1c89c02a
http://europepmc.org/articles/PMC7756571
http://europepmc.org/articles/PMC7756571
Publikováno v:
JACC: CardioOncology
Ye, J Z, Hansen, F B, Mills, R W & Lundby, A 2021, ' Oncotherapeutic Protein Kinase Inhibitors Associated With Pro-Arrhythmic Liability ', JACC: CardioOncology, vol. 3, no. 1, pp. 88-97 . https://doi.org/10.1016/j.jaccao.2021.01.009
Ye, J Z, Hansen, F B, Mills, R W & Lundby, A 2021, ' Oncotherapeutic Protein Kinase Inhibitors Associated With Pro-Arrhythmic Liability ', JACC: CardioOncology, vol. 3, no. 1, pp. 88-97 . https://doi.org/10.1016/j.jaccao.2021.01.009
Background Ibrutinib is a protein kinase inhibitor that has been widely successful in treating multiple common variations of B-cell cancers. However, an unfortunate side effect of ibrutinib is that it predisposes patients to development of atrial fib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c39be5ab71f99585683f199624745bd
https://pubmed.ncbi.nlm.nih.gov/34396309
https://pubmed.ncbi.nlm.nih.gov/34396309
Autor:
Suresh K. Mendu, Bimal N. Desai, David J. Milan, Pui-ying Lam, Randall T. Peterson, Baohui Zheng, Hugo Padilla, Robert W. Mills
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Optogenetics is a powerful research approach that allows localized optical modulation of selected cells within an animal via the expression of genetically encoded photo-excitable ion channels. Commonly used optogenetic techniques rely on the expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77d2df7fee211d98cce20a97d7b6003
http://link.springer.com/article/10.1038/s41598-017-11791-z
http://link.springer.com/article/10.1038/s41598-017-11791-z
Autor:
Jesper V. Olsen, Nora Linscheid, Bo Hjorth Bentzen, Lars Juhl Jensen, Ulrike Leurs, Pia R. Lundegaard, Alicia Lundby, Johan Ziruo Ye, Alberto Santos, Morten B. Thomsen, Morten S. Olesen, Robert W. Mills, Christian Stolte, Pi Camilla Poulsen, Kirstine Calloe
The study of human cardiac pathologies often relies on research conducted in model organisms to gain molecular insight into disease and to develop novel treatment strategies; however, translating findings from model organisms back to human can presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8831a3858d2b86f4adc773cf49473c44
https://doi.org/10.1101/2020.01.08.897595
https://doi.org/10.1101/2020.01.08.897595
Autor:
Alvaro Alonso, Donna M. Muzny, Moritz F. Sinner, Ching-Ti Liu, John Barnard, Eric Boerwinkle, David J. Milan, Thomas P. Cappola, Robert W. Mills, Alanna C. Morrison, Thomas Lumley, Colleen M. Sitlani, Dan E. Arking, Michael Morley, L. Adrienne Cupples, Nona Sotoodehnia, Rebecca D. Jackson, Mina K. Chung, Paul M.L. Janssen, Ning Li, Stephen S. Rich, Jerome I. Rotter, Christopher J. O'Donnell, David R. Van Wagoner, Kenneth B. Margulies, Xiaoyan Yin, Gus J. Vlahakes, Sara L. Pulit, Caroline N. Herndon, Vadim V. Fedorov, Joshua C. Bis, Susan R. Heckbert, Jared W. Magnani, Bruce M. Psaty, Steven A. Lubitz, Christopher Newton-Cheh, Honghuang Lin, Peter J. Mohler, Patrick T. Ellinor, Elena Dolmatova, Jonathan D. Smith, Vincenzo Macri, William J. Hucker, Emelia J. Benjamin, Richard A. Gibbs, Jennifer A. Brody
Publikováno v:
Circulation: Genomic and Precision Medicine. 11
Background: Genetic variants at the SCN5A / SCN10A locus are strongly associated with electrocardiographic PR and QRS intervals. While SCN5A is the canonical cardiac sodium channel gene, the role of SCN10A in cardiac conduction is less well character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc81b6fd2ed922f6ab9ec94ff3832ff
https://doi.org/10.1161/circgen.116.001663
https://doi.org/10.1161/circgen.116.001663
Autor:
Gabriel Gonzalez, Philipp T. Moser, Glenn R. Gaudette, Jonathan M. Charest, Sarah E. Gilpin, Tatsuya Okamoto, Harald C. Ott, Joshua R. Gershlak, Robert W. Mills, David J. Milan, Jacques P. Guyette, Bernhard J. Jank
Publikováno v:
Circulation Research. 118:56-72
Rationale: More than 25 million individuals have heart failure worldwide, with ≈4000 patients currently awaiting heart transplantation in the United States. Donor organ shortage and allograft rejection remain major limitations with only ≈2500 hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0768fb3ea99570f25eb690f390d73c5d
https://doi.org/10.1161/circresaha.115.306874
https://doi.org/10.1161/circresaha.115.306874
Autor:
Elena Dolmatova, Moritz F. Sinner, Steven A. Lubitz, Maxim Imakaev, Jiangchuan Ye, Emelia J. Benjamin, Victoria A. Parsons, Nathan R. Tucker, Honghuang Lin, Kathryn L. Lunetta, Jordan Leyton-Mange, Rebecca R. Cooper, Leonid A. Mirny, Patrick T. Ellinor, William J. Hucker, Gus J. Vlahakes, Lu-Chen Weng, Heather Jameson, David J. Milan, Robert W. Mills
Publikováno v:
PMC
Background— Atrial fibrillation (AF) affects over 33 million individuals worldwide. Genome-wide association studies have identified at least 30 AF loci, but the mechanisms through which individual variants lead to altered disease risk have remained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abd9ff20272a245d63f6735176fcc44
https://hdl.handle.net/1721.1/124839
https://hdl.handle.net/1721.1/124839
Autor:
Nathan R, Tucker, Elena V, Dolmatova, Honghuang, Lin, Rebecca R, Cooper, Jiangchuan, Ye, William J, Hucker, Heather S, Jameson, Victoria A, Parsons, Lu-Chen, Weng, Robert W, Mills, Moritz F, Sinner, Maxim, Imakaev, Jordan, Leyton-Mange, Gus, Vlahakes, Emelia J, Benjamin, Kathryn L, Lunetta, Steven A, Lubitz, Leonid, Mirny, David J, Milan, Patrick T, Ellinor
Publikováno v:
Circulation. Cardiovascular genetics. 10(5)
Atrial fibrillation (AF) affects over 33 million individuals worldwide. Genome-wide association studies have identified at least 30 AF loci, but the mechanisms through which individual variants lead to altered disease risk have remained unclear for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33ee3d85471e884aec52a04f95d665dd
https://pubmed.ncbi.nlm.nih.gov/28974515
https://pubmed.ncbi.nlm.nih.gov/28974515