Zobrazeno 1 - 10
of 331
pro vyhledávání: '"Robert W Mahley"'
Autor:
Jason A Watts, Christopher Grunseich, Yesenia Rodriguez, Yaojuan Liu, Dongjun Li, Joshua T Burdick, Alan Bruzel, Robert J Crouch, Robert W Mahley, Samuel H Wilson, Vivian G Cheung
Publikováno v:
Nucleic Acids Res
RNA is modified by hundreds of chemical reactions and folds into innumerable shapes. However, the regulatory role of RNA sequence and structure and how dysregulation leads to diseases remain largely unknown. Here, we uncovered a mechanism where RNA a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34db6494b76e0b415e1f824b580bf63
https://doi.org/10.1093/nar/gkac1107
https://doi.org/10.1093/nar/gkac1107
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8a1922d56688d94f9b6dee5c56cb191
https://doi.org/10.1002/alz.061116
https://doi.org/10.1002/alz.061116
Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases
Autor:
Yadong Huang, Robert W. Mahley
Publikováno v:
Neurobiology of Disease, Vol 72, Iss , Pp 3-12 (2014)
Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3, and apoE4) with different effects on lipid and neuronal homeostasis.
Externí odkaz:
https://doaj.org/article/98ce5aefee644cd895dcac6034b8a94e
Autor:
Robert W. Mahley
Publikováno v:
Current Opinion in Neurobiology. 79:102684
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac8b578864d6e9c55068eccf3c2cfdbd
https://doi.org/10.1016/j.conb.2023.102684
https://doi.org/10.1016/j.conb.2023.102684
Autor:
Jason A. Watts, Christopher Grunseich, Yesenia Rodriguez, Yaojuan Liu, Dongjun Li, Joshua T Burdick, Alan Bruzel, Robert J. Crouch, Robert W. Mahley, Samuel H. Wilson, Vivian G. Cheung
The DNA genetic code and the RNA regulatory code determine phenotypes from gene expression to disease susceptibility. DNA sequence variants lead to phenotypic differences among individuals, while within an individual, RNA dynamically confers cell ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaad3494e85502d6d93caa34951b8104
https://doi.org/10.1101/2022.05.01.489793
https://doi.org/10.1101/2022.05.01.489793
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 2, Pp 422-430 (2010)
We investigated the effects of single nucleotide polymorphisms (SNPs) of the hepatic lipase gene (LIPC) on plasma HDL-cholesterol (HDL-C) levels in Turks, a population with low levels of HDL-C. All exons and six evolutionarily conserved regions from
Externí odkaz:
https://doaj.org/article/cfa4bf71877049698799a27c94f6c87d
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 1, Pp 144-153 (2006)
The apolipoprotein A-V gene (APOA5) plays an important role in determining plasma triglyceride levels. We studied the effects of APOA5 polymorphisms on plasma triglyceride levels in Turks, a population with low levels of HDL cholesterol and a high pr
Externí odkaz:
https://doaj.org/article/6deb4f786ca64644af8fca388075aae5
Autor:
Yi Yu, Diego F. Wyszynski, Dawn M. Waterworth, Steven D. Wilton, Philip J. Barter, Y. Antero Kesäniemi, Robert W. Mahley, Ruth McPherson, Gérard Waeber, Thomas P. Bersot, Qianli Ma, Sanjay S. Sharma, Douglas S. Montgomery, Lefkos T. Middleton, Scott S. Sundseth, Vincent Mooser, Scott M. Grundy, Lindsay A. Farrer
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2202-2213 (2005)
We conducted a genome-wide scan using variance components linkage analysis to localize quantitative-trait loci (QTLs) influencing triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol, and total choleste
Externí odkaz:
https://doaj.org/article/62970aaa764b4cc892139ccbc37b6e39
Autor:
Robert W. Mahley, Perihan Arslan, Gülden Pekcan, Guy M. Pépin, Ayşen Ağaçdiken, Nilgün Karaağaoğlu, Neslişah Rakıcıoğlu, Berat Nursal, Pınar Dayanıklı, K. Erhan Palaoğlu, Thomas P. Bersot
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 12, Pp 1996-2006 (2001)
In Turkish adults, HDL cholesterol (HDL-C) levels are 10–15 mg/dl lower than those of adults in western Europe and the United States. In this study, we determined whether HDL-C levels in Turks are low from birth to adulthood and assessed the effect
Externí odkaz:
https://doaj.org/article/25d13b0c48d34562b1c1c1be271f7d8d
Autor:
Helén L. Dichek, Sarah M. Johnson, Hassibullah Akeefe, Giai T. Lo, Ezra Sage, Christine E. Yap, Robert W. Mahley
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 2, Pp 201-210 (2001)
To address the role of the noncatalytic ligand function of hepatic lipase (HL) in low density lipoprotein (LDL) receptor-mediated lipoprotein metabolism, we characterized transgenic mice lacking the LDL receptor (LDLR) that express either catalytical
Externí odkaz:
https://doaj.org/article/86df620c6d5e4779bff5513dace5a7b5